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63-92-3

供应商 相关产品 基本信息 物理化学性质 应用领域 安全数据 化学品安全说明书(MSDS) 图谱信息 知名试剂公司产品信息 盐酸酚苄明价格(试剂级) 常见问题列表

产品图片

基本信息

中文
盐酸酚苄明
英文名称
2-(n-benzyl-2-chloroethylamino)-1-phenoxypropane hydrochloride
BENZENE METHANAMINE HYDROCHLORIDE
DIBENZYLINE HYDROCHLORIDE
n-(2-chloroethyl)-n-(1-methyl-2-phenoxyethyl)benzenemethanamine hydrochloride
N-(2-CHLOROETHYL)-N-(1-METHYL-2-PHENOXYETHYL)BENZYLAMINE HYDROCHLORIDE
N-PHENOXYISOPROPYL-N-BENZYL-2-CHLOROETHYLAMINE HYDROCHLORIDE
PHENOXYBENZAMINE
PHENOXYBENZAMINE HCL
PHENOXYBENZAMINE HYDROCHLORIDE
bensylytnen
benzyl(2-chloroethyl)(1-methyl-2-phenoxyethyl)aminehydrochloride
dibenzyran
fenossibenzamina
fenoxybenzamin
n-(2-chloroethyl)-n-(1-methyl-2-phenoxyethyl)-benzenemethanaminhydrochlo
n-(2-chloroethyl)-n-(1-methyl-2-phenoxyethyl)-benzylaminhydrochloride
n-2-phenoxyisopropyl-n-benzyl-chloroethylaminehydrochloride
n-benzyl-n-phenoxyisopropyl-beta-chlorethylaminehydrochloride
nci-c01661
n-phenoxyisopropyl-n-benzyl-beta-chloroethylaminehydrochloride
CAS
63-92-3
中文名称
N-(1-甲基-2-苯氧乙基)-N-(2-氯乙基)苯甲胺盐酸盐
盐酸苯氧苄胺
盐酸酚苄明
苯苄胺
苯氧苄胺
酚苄胺
竹林胺
盐酸酚芬明
酚苄明
EINECS 编号
200-569-7
分子式
C12H12ClNO
MDL 编号
MFCD00599580
分子量
221.68
MOL 文件
63-92-3.mol

物理化学性质

外观性状
白色结晶性粉末。熔点137.5-140℃。溶于乙醇、氯仿、丙二醇,略溶于苯,微溶于冷水。其游离碱熔点38-40℃,溶于苯。
熔点 
137.5°C
储存条件 
2-8°C

溶解度 
H2O: slightly soluble

form 
powder

color 
white

水溶解性 
<0.01 g/100 mL at 18.5 ºC
Merck 
7256

应用领域

用途一
α-受体阴断剂,选择性强,作用持久。主要用于嗜铬细胞瘤、雷诺氏综合症、物足发绀及冻疮后遗症。

安全数据

危险品标志 
Xn
危险类别码 
R22-R40
安全说明 
S22-S36/37/39-S45
WGK Germany 
3

RTECS 
DP3750000

海关编码
2922299000

化学品安全说明书(MSDS)

图谱信息

知名试剂公司产品信息

盐酸酚苄明价格(试剂级)

盐酸酚苄明价格(试剂级)
更新日期产品编号产品名称包装价格
2021/09/07D0158盐酸酚苄明
Phenoxybenzamine Hydrochloride
1G595元
2021/09/07D0158盐酸酚苄明
Phenoxybenzamine Hydrochloride
25G4175元

常见问题列表

生物活性
Phenoxybenzamine HCl (NSC 37448, NCI-c01661)是一种非选择性,不可逆α受体拮抗剂,IC50为550 nM。
靶点
TargetValue
α-adrenergic receptor

体外研究

The IC 50 (100 nM) derived from the blockade of [ 3 H]yohimbine binding by Phenoxybenzamine hydrochloride is significantly less than the IC 50 (550 nM) for the corresponding reversal by Phenoxybenzamine hydrochloride of the effects of norepinephrine on cyclic AMP accumulation. Phenoxybenzamine hydrochloride (50 nM) in conbination with Phenoxybenzamine hydrochloridetolamine (1000 nM) enhances Phenoxybenzamine hydrochlorideylephrine-induced contraction compared with pretreatment with Phenoxybenzamine hydrochloride (50 nM) alone in endothelium-intact aortae. Combined treatment with either dexmedetomidine (300 or 1000 nM) and Phenoxybenzamine hydrochloride (50 nM) or Phenoxybenzamine hydrochloridetolamine (1000 nM) and Phenoxybenzamine hydrochloride (50 nM) enhance Phenoxybenzamine hydrochlorideylephrine-induced contraction compared with Phenoxybenzamine hydrochloride alone (50 nM). In addition, combined treatment with Phenoxybenzamine hydrochloridetolamine and Phenoxybenzamine hydrochloride enhances Phenoxybenzamine hydrochlorideylephrine-induced contraction compared with dexmedetomidine (1000 nM) and Phenoxybenzamine hydrochloride combined treatment. ​Combined treatment with high concentrations of dexmedetomidine (1000 nM) and Phenoxybenzamine hydrochloride enhances Phenoxybenzamine hydrochlorideylephrine-induced contraction compared with combined treatment with low concentrations of dexmedetomidine (300 nM) and Phenoxybenzamine hydrochloride. Phenoxybenzamine hydrochloride (0.1-100 μM) inhibits glioma proliferation, migration, and invasion and suppresses the tumorigenesis capacity. Phenoxybenzamine hydrochloride also inhibits self-renewal of glioma stem-like cells. Phenoxybenzamine hydrochloride activates LINGO-1 and inhibits the TrkB-Akt pathway. Phenoxybenzamine hydrochloride (0.1 μM-1 mM) preserves primary neurons within the CA1, CA3 and dentate gyrus and produces a robust neuroprotective effect, and prevents neuronal death from OGD in all regions of the hippocampus when delivered at 2, 4, and 8 h post-OGD at 100 μM.


体内研究

Phenoxybenzamine hydrochloride (20 nM, s.c.) effectively suppresses the tumorigenesis of glioma cells in mice and the cell density in Phenoxybenzamine hydrochloride-U87MG xenografts decreases significantly. Phenoxybenzamine hydrochloride (1 mg/kg, i.v.) treated rats shows significant improvements in NSS and foot fault scoring.


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