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Phthalide

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Phthalide Basic information
Phthalide Chemical Properties
Safety Information
MSDS
Phthalide Usage And Synthesis
  • Chemical Properties

    White powder; sweet tonka, coumarin, powdery, coconut, phenolic, lactonic aroma.

  • Chemical PropertiesWHITE TO LIGHT BEIGE CRYSTALLINE POWDER
  • DefinitionChEBI: A gamma-lactone that is 1,3-dihydro-2-benzofuran in which the hydrogens at position 1 are replaced by an oxo group.
  • Aroma threshold valuesLow strength odor, Tonka type.
  • Taste threshold valuesSweet coumarin, coconut, creamy, anisic, green vegetable, floral taste at 100 ppm in water.
  • Synthesis Reference(s)Chemistry Letters, 23, p. 1149, 1994
    The Journal of Organic Chemistry, 68, p. 9423, 2003 DOI: 10.1021/jo0350763
    Tetrahedron Letters, 7, p. 6097, 1966
  • PharmacologySystemic fungicide giving effective preventive control of the rice blast fungus in rice as foliar spray.
  • Purification MethodsCrystallise phthalide from water (75mL/g) and dry it in air on filter paper. [Beilstein 17/10 V 7.]
  • Toxicity evaluationMammalian toxicology. Oral: Acute oral LD50 for rats and mice >10000 mg/kg. Skin and eye: Acute percutaneous LD50 for rats and mice >10000 mg/kg. Not a shaved skin irritant, eye irritant (rabbits). Inhalation LC50 (4 h) for rats >4.1 mg/L air. NOEL: (2 yr) for rats 2000, mice 100 mg/kg diet.
Phthalide Preparation Products And Raw materials
Phthalide(87-41-2)Related Product Information
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