White powder; sweet tonka, coumarin, powdery, coconut, phenolic, lactonic aroma.
Phthalide may be used in scaffolds for the design of high potency monoamine oxidase (MAO) inhibitors.
ChEBI: A gamma-lactone that is 1,3-dihydro-2-benzofuran in which the hydrogens at position 1 are replaced by an oxo group.
Low strength odor, Tonka type.
Sweet coumarin, coconut, creamy, anisic, green vegetable, floral taste at 100 ppm in water.
Chemistry Letters, 23, p. 1149, 1994
The Journal of Organic Chemistry, 68, p. 9423, 2003
DOI: 10.1021/jo0350763Tetrahedron Letters, 7, p. 6097, 1966
Flammability and Explosibility
Not classified
Systemic fungicide giving effective preventive
control of the rice blast fungus in rice as foliar spray.
Crystallise phthalide from water (75mL/g) and dry it in air on filter paper. [Beilstein 17/10 V 7.]
Mammalian toxicology. Oral: Acute oral
LD50 for rats and mice >10000 mg/kg. Skin and eye: Acute
percutaneous LD50 for rats and mice >10000 mg/kg. Not
a shaved skin irritant, eye irritant (rabbits). Inhalation
LC50 (4 h) for rats >4.1 mg/L air. NOEL: (2 yr) for rats
2000, mice 100 mg/kg diet.
