Phthalide
- Product Name:Phthalide
- CAS:87-41-2
- MF:C8H6O2
- MW:134.13
- EINECS:201-744-0
- Mol File:87-41-2.mol
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Phthalide Chemical Properties
- Melting point:71-74 °C(lit.)
- Boiling point:290 °C(lit.)
- Density 1.1
- FEMA 4195 | PHTHALIDE
- refractive index 1.5360 (estimate)
- Flash point:152 °C
- storage temp. Store below +30°C.
- form Crystalline Powder
- color White to light beige
- Water Solubility sparingly soluble
- BRN 114632
- InChIKeyWNZQDUSMALZDQF-UHFFFAOYSA-N
- CAS DataBase Reference87-41-2(CAS DataBase Reference)
- NIST Chemistry Reference1(3H)-Isobenzofuranone(87-41-2)
- EPA Substance Registry SystemPhthalide (87-41-2)
- Hazard Codes Xi
- Risk Statements 36-36/37/38
- Safety Statements 26-36-24/25-37/39
- WGK Germany 3
- RTECS TI3520000
- TSCA Yes
- HS Code 29322980
- Language:EnglishProvider:Phthalide
- Language:EnglishProvider:SigmaAldrich
- Language:EnglishProvider:ACROS
- Language:EnglishProvider:ALFA
Phthalide Usage And Synthesis
- Chemical Properties
White powder; sweet tonka, coumarin, powdery, coconut, phenolic, lactonic aroma.
- Chemical PropertiesWHITE TO LIGHT BEIGE CRYSTALLINE POWDER
- DefinitionChEBI: A gamma-lactone that is 1,3-dihydro-2-benzofuran in which the hydrogens at position 1 are replaced by an oxo group.
- Aroma threshold valuesLow strength odor, Tonka type.
- Taste threshold valuesSweet coumarin, coconut, creamy, anisic, green vegetable, floral taste at 100 ppm in water.
- Synthesis Reference(s)Chemistry Letters, 23, p. 1149, 1994
The Journal of Organic Chemistry, 68, p. 9423, 2003 DOI: 10.1021/jo0350763
Tetrahedron Letters, 7, p. 6097, 1966 - PharmacologySystemic fungicide giving effective preventive control of the rice blast fungus in rice as foliar spray.
- Purification MethodsCrystallise phthalide from water (75mL/g) and dry it in air on filter paper. [Beilstein 17/10 V 7.]
- Toxicity evaluationMammalian toxicology. Oral: Acute oral LD50 for rats and mice >10000 mg/kg. Skin and eye: Acute percutaneous LD50 for rats and mice >10000 mg/kg. Not a shaved skin irritant, eye irritant (rabbits). Inhalation LC50 (4 h) for rats >4.1 mg/L air. NOEL: (2 yr) for rats 2000, mice 100 mg/kg diet.
Phthalide Preparation Products And Raw materials
- (+)-Bicuculline Pyromellitic Dianhydride ERYTHROSIN B 5(6)-Aminofluorescein FLUORESCEIN FLUORESCEIN DIACETATE 6-Aminofluorescein THYMOLPHTHALEIN MONOPHOSPHATE DISODIUM SALT 3-Bromophthalide p-Toluic acid Methyl 4-methylbenzoate Methyl 4-(bromomethyl)benzoate Phthalide 3-(Trifluoromethyl)benzoic acid Anthranilic acid m-Toluic acid methylbenzoic acid 5-Cyanophthalide
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