Description
White powder; sweet tonka, coumarin, powdery, coconut, phenolic, lactonic aroma.
Uses
Phthalide may be used in scaffolds for the design of high potency monoamine oxidase (MAO) inhibitors.
Definition
ChEBI: A gamma-lactone that is 1,3-dihydro-2-benzofuran in which the hydrogens at position 1 are replaced by an oxo group.
Aroma threshold values
Low strength odor, Tonka type.
Taste threshold values
Sweet coumarin, coconut, creamy, anisic, green vegetable, floral taste at 100 ppm in water.
Synthesis Reference(s)
Chemistry Letters, 23, p. 1149, 1994
The Journal of Organic Chemistry, 68, p. 9423, 2003
DOI: 10.1021/jo0350763Tetrahedron Letters, 7, p. 6097, 1966
Flammability and Explosibility
Not classified
Pharmacology
Systemic fungicide giving effective preventive
control of the rice blast fungus in rice as foliar spray.
Purification Methods
Crystallise phthalide from water (75mL/g) and dry it in air on filter paper. [Beilstein 17/10 V 7.]
Toxicity evaluation
Mammalian toxicology. Oral: Acute oral
LD
50 for rats and mice >10000 mg/kg. Skin and eye: Acute
percutaneous LD
50 for rats and mice >10000 mg/kg. Not
a shaved skin irritant, eye irritant (rabbits). Inhalation
LC50 (4 h) for rats >4.1 mg/L air. NOEL: (2 yr) for rats
2000, mice 100 mg/kg diet.
