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Anthranilic acid

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Anthranilic acid Basic information
Anthranilic acid Chemical Properties
  • Melting point:144-148 °C(lit.)
  • Boiling point:251.96°C (rough estimate)
  • Density 1.412
  • vapor density 4.7 (vs air)
  • refractive index 1.5323 (estimate)
  • Flash point:150°C
  • storage temp. Store at 0°C
  • solubility ethanol: may be clear to slightly hazy
  • pka2.108(at 25℃)
  • form powder
  • color White to pale yellow crystalline
  • PH RangeNon-B uorescence (1.5) light blue B uorescence (3.0)
  • Water Solubility 5.7 g/L (25 ºC)
  • Merck 14,422
  • BRN 471803
  • Stability:Stable. Incompatible with strong oxidizing agents.
  • Major Applicationbottom antireflective coatings, semiconductor devices, inks, hair dyes, cosmetics, treatment of chronic inflammatory diseases, depression
  • CAS DataBase Reference118-92-3(CAS DataBase Reference)
  • NIST Chemistry ReferenceAnthranilic acid(118-92-3)
  • IARC3 (Vol. 16, Sup 7) 1987
  • EPA Substance Registry SystemAnthranilic acid (118-92-3)
Safety Information
Anthranilic acid Usage And Synthesis
  • Chemical PropertiesWhite to off white crystalline powder
  • UsesDyes, drugs, perfumes, and pharmaceuticals.
  • DefinitionChEBI: An aminobenzoic acid that is benzoic acid having a single amino substituent located at position 2. It is a metabolite produced in L-tryptophan-kynurenine pathway in the central nervous system.
  • Synthesis Reference(s)Chemical and Pharmaceutical Bulletin, 29, p. 1159, 1981 DOI: 10.1248/cpb.29.1159
    Journal of the American Chemical Society, 107, p. 5008, 1985 DOI: 10.1021/ja00303a038
  • General DescriptionOdorless white to pale-yellow or tan crystalline powder with a sweetish taste.
  • Air & Water ReactionsAnthranilic acid may be sensitive to prolonged exposure to air and light. Insoluble in water.
  • Reactivity ProfileAnthranilic acid is incompatible with strong oxidizers.
  • HazardQuestionable carcinogen.
  • Fire HazardAnthranilic acid is combustible.
  • Safety ProfileModerately toxic by ingestion and intraperitoneal routes. Experimental reproductive effects. Human mutation data reported. Questionable carcinogen with experimental tumorigenic data. Combustible. When heated to decomposition it emits toxic fumes of NOx.
  • Purification MethodsCrystallise anthranilic acid from water (charcoal). It has also been recrystallised from 50% aqueous acetic acid. It sublimes in a vacuum. [Beilstein 14 IV 1004.]
Anthranilic acid Preparation Products And Raw materials
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