N-Acetylanthranilic acid

N-Acetylanthranilic acid (Item No. 18707) is an analytical reference standard categorized as a precursor in the synthesis of methaqualone (Item Nos. 20283 | 9000636).1 N-Acetylanthranilic Acid is regulated as a List I chemical in the United States. This product is intended for research and forensic applications.WARNING This product is not for human or veterinary use.

solid

N-Acetylanthranilic acid is a pharmaceutical intermediate used in the production of the non-barbiturate hypnotic drug methaqualone.

ChEBI: An amidobenzoic acid consisting of anthranilic acid carrying an N-acetyl group.

The Journal of Organic Chemistry, 46, p. 4614, 1981 DOI: 10.1021/jo00335a075
Tetrahedron Letters, 23, p. 4473, 1982 DOI: 10.1016/S0040-4039(00)85631-2

Moderately toxic by ingestion.When heated to decomposition it emits toxic vapors ofNOx.

Wash the acid with distilled H2O and recrystallise it from aqueous AcOH, dry it and recrystallise again from EtOAc. Also recrystallise it from water or EtOH. UV: max 221, 252 and 305nm (EtOH). The amide crystallises from aqueous EtOH and has m 186-187o and max 218, 252 and 301nm. [Chattaway J Chem Soc 2495 1931, Walker J Am Chem Soc 77 6698 1955, Beilstein 14 H 337, 14 I 540, 14 II 219, 14 III 922.]