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p-Acetylamino benzoic acid

Basic information Safety Related Supplier
p-Acetylamino benzoic acid Basic information
p-Acetylamino benzoic acid Chemical Properties
Safety Information
  • Risk Statements 36/37/38
  • Safety Statements 24/25
  • WGK Germany 3
  • TSCA Yes
  • HS Code 29242995
MSDS
p-Acetylamino benzoic acid Usage And Synthesis
  • Chemical Propertieswhite or off-white powder or crystals
  • Originator4-Acetamidobenzoic acid ,ARIAC
  • Usesimmune stimulant (component)
  • UsesAcedoben is the acetylated derivative of p-aminobenzoic acid (PABA). Acedoben is a metabolite of the anesthetic Benzocaine (B202970).
  • DefinitionChEBI: A amidobenzoic acid that consists of benzoic acid bearing an acetamido substituent at position 4.
  • Manufacturing ProcessInto a 2 L, 3-necked flask set in a tub and equipped with a stirrer, an air condenser (drying tube), thermometer, was placed 860 ml of water, 43.0 g of MgSO4 and 43.0 g of sodium acetate and heated on water bath. Into heated solution to 70°C stirring 43.0 g of N-p-tolylacetamide were added. Then 136.0 g of KMnO4 by small portions were added at 75°-80°C. The reaction mixture allow to stand for 6 h and stirring was continue till the solution became colorless. Hot solution was filtered and filtrate treated hydrochloric acid to slightly acidic pH. After that 44.0 g (85%) of p-acetoaminobenzoic acid was obtained as white precipitate, melting point 250°C.
  • Therapeutic FunctionAntiviral
  • General DescriptionNeedles or off-white powder.
  • Air & Water ReactionsWater insoluble.
  • Reactivity ProfileSimultaneously an amide and a carboxylic acid.
  • Fire HazardFlash point data for p-Acetylamino benzoic acid are not available; however, p-Acetylamino benzoic acid is probably combustible.
p-Acetylamino benzoic acid Preparation Products And Raw materials
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