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(+)-Bicuculline

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(+)-Bicuculline Basic information
(+)-Bicuculline Chemical Properties
Safety Information
MSDS
(+)-Bicuculline Usage And Synthesis
  • Chemical PropertiesPale Yellow Solid
  • UsesGABAA receptor antagonist.
  • UsesGABAa antagonist
  • UsesAlkaloid naturally occurring in the d-form. Shows GABA antagonist activity.
  • Biological ActivityClassical GABA A antagonist.
  • Safety ProfileA poison by intraperitoneal route.When heated to decomposition it emits toxic vapors ofNOx.
  • Purification MethodsIt crystallises from CHCl3/MeOH as plates. The crystals melt at 177o, then solidify and re-melt at 193-195o [Manske Canad J Research 21B 13 1943]. It is soluble in CHCl3, *C6H6, EtOAc but sparingly soluble in EtOH, MeOH and Et2O. [Stereochem: Blaha et al. Collect Czech Chem Commun 29 2328 1964, Snatzke et al. Tetrahedron 25 5059 1969, Pharmcol: Curtis et al. Nature 266 1222 1970, Beilstein 27 III/IV 1900].
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