Basic information Description References Safety Related Supplier
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Econazole nitrate

Basic information Description References Safety Related Supplier
Econazole nitrate Basic information
Econazole nitrate Chemical Properties
  • Melting point:162°C
  • storage temp. Refrigerator
  • solubility chloroform/methanol: soluble25mg/mL (choloroform:methanol (1:1))
  • form powder
  • color white to off-white
  • Water Solubility <0.1 g/100 mL at 19 ºC
  • Merck 14,3502
  • InChIKeyDDXORDQKGIZAME-UHFFFAOYSA-N
  • CAS DataBase Reference24169-02-6(CAS DataBase Reference)
  • EPA Substance Registry SystemEconazole mononitrate (24169-02-6)
Safety Information
  • Hazard Codes Xn,Xi
  • Risk Statements 22-36/38-36/37/38
  • Safety Statements 26-36-36/37
  • WGK Germany 3
  • RTECS NI4450000
  • HS Code 29332900
  • ToxicityLD50 in mice, rats (mg/kg): 462.7, 667.7 orally (Thienpont)
MSDS
Econazole nitrate Usage And Synthesis
  • DescriptionEconazole nitrate is the nitrate salt form of Econazole. It belongs to imidazole-class antifungal medication sold in various places around the world including US, Canada, Western Europe, and Asia. It is usually manufactured into cream form for sale. Econazole nitrate is mainly used for the treatment of skin infections including athlete's foot, tinea, pityriasis versicolor, ringworm, and jock itch caused by fungi such as Trichophyton rubrum, Trichophyton tonsurans and Microsporum audouini. As an imidazole-class drug, Econazole nitrate takes effects through inhibiting the biosynthesis of ergosterol, a key component of fungal cell membrane, thus disrupting the normal permeability of fungal membrane. This causes leakage of essential cellular contents of fungi, further killing them.
  • Referenceshttp://www.rxlist.com/econazole-nitrate-cream-drug/clinical-pharmacology.htm
    https://en.wikipedia.org/wiki/Econazole
    http://www.pdr.net/drug-summary/Econazole-Nitrate-econazole-nitrate-731
  • Chemical PropertiesWhite to Off-White Solid
  • UsesAntifungal;Ergosterol synthesis inhibition
  • UsesAzole antifungal
  • brand nameSpectazole (Johnson & Johnson).
  • General DescriptionWhite crystalline powder.
  • Air & Water ReactionsInsoluble in water.
  • Fire HazardFlash point data for Econazole nitrate are not available; however, Econazole nitrate is probably combustible.
Econazole nitrate Preparation Products And Raw materials
Econazole nitrate(24169-02-6)Related Product Information
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