1-Hexanol

Bezeichnung:1-Hexanol

CAS-Nr111-27-3

Englisch Name:1-Hexanol

CBNumberCB8461421

SummenformelC6H14O

Molgewicht102.17

MOL-Datei111-27-3.mol

Synonyma

Hexan-1-ol

1-Hexanol

Hexylalkohol

1-Hexanol physikalisch-chemischer Eigenschaften

Schmelzpunkt	-52 °C (lit.)
Siedepunkt	156-157 °C (lit.)
Dichte	0.814 g/mL at 25 °C (lit.)
Dampfdichte	4.5 (vs air)
Dampfdruck	1 mm Hg ( 25.6 °C)
Brechungsindex	n20/D 1.418(lit.)
FEMA	2567 \| HEXYL ALCOHOL
Flammpunkt	140 °F
storage temp.	no restrictions.
Löslichkeit	ethanol: soluble(lit.)
pka	15.38±0.10(Predicted)
Aggregatzustand	Liquid
Farbe	Clear colorless
Relative polarity	0.559
Geruch (Odor)	Sweet; mild.
Odor Threshold	0.006ppm
Explosionsgrenze	1.2-7.7%(V)
Geruchsart	herbal
Wasserlöslichkeit	6 g/L (25 ºC)
JECFA Number	91
Merck	14,4697
BRN	969167
Dielectric constant	13.3（24℃）
Stabilität	Stable. Substances to be avoided include strong acids, strong oxidizing agents. Combustible.
LogP	1.8
CAS Datenbank	111-27-3(CAS DataBase Reference)
NIST chemische Informationen	1-Hexanol(111-27-3)
EPA chemische Informationen	1-Hexanol (111-27-3)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22
S-Sätze:	24/25
RIDADR	UN 2282 3/PG 3
WGK Germany	1
RTECS-Nr.	MQ4025000
Selbstentzündungstemperatur	559 °F
TSCA	Yes
HazardClass	3
PackingGroup	III
HS Code	29051900
Giftige Stoffe Daten	111-27-3(Hazardous Substances Data)
Toxizität	LD50 oral in rat: 720mg/kg

Gefahreninformationscode (GHS)

1-Hexanol Chemische Eigenschaften,Einsatz,Produktion Methoden

ERSCHEINUNGSBILD
FARBLOSE FLüSSIGKEIT MIT CHARAKTERISTISCHEM GERUCH.
CHEMISCHE GEFAHREN
Reagiert mit starken Oxidationsmitteln.
ARBEITSPLATZGRENZWERTE
TLV nicht festgelegt.
MAK: IIb (nicht festgelegt, aber Informationen vorhanden). (DFG 2008).
AUFNAHMEWEGE
Aufnahme in den Körper durch Inhalation und durch Verschlucken.
INHALATIONSGEFAHREN
Nur ungenügende Angaben vorhanden über die Geschwindigkeit, mit der eine gesundheitsschädliche Konzentration in der Luft beim Verdampfen bei 20°C erreicht wird.
WIRKUNGEN BEI KURZZEITEXPOSITION
WIRKUNGEN BEI KURZZEITEXPOSITION:
Die Substanz reizt die Atemwege und die Haut. Die Substanz reizt stark die Augen. Verschlucken kann zur Aufnahme in der Lunge führen; Gefahr der Aspirationspneumonie.
WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION
Die Flüssigkeit entfettet die Haut.
LECKAGE
Ausgelaufene Flüssigkeit in abgedeckten Behältern sammeln. Reste mit Sand oder inertem Absorptionsmittel aufnehmen und an einen sicheren Ort bringen. Persönliche Schutzausrüstung: Atemschutzfilter für organische Gase und Dämpfe.
R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
Aussehen Eigenschaften
C6H14O, Hexylalkohol, n-Hexanol. Farblose Flüssigkeit mit charakteristischem Geruch.
Gefahren für Mensch und Umwelt
Gesundheitsschädlich beim Verschlucken.
Reizt die Atmungsorgane und die Haut. Resorption größerer Mengen kann zur Narkose führen.
Nicht mit starken Oxidationsmitteln in Berührung bringen.
LD₅₀ (oral, Ratte): 720 mg/kg.
Schutzmaßnahmen und Verhaltensregeln
Geeignete Schutzhandschuhe als kurzzeitiger Spritzschutz.
Verhalten im Gefahrfall
Dämpfe nicht einatmen.
Mit flüssigkeitsbindendem Material, z.B. Rench Rapid aufnehmen. Der Entsorgung zuführen. Nachreinigen.
Kohlendioxid, Wasser, Pulver.
Brennbar. Dämpfe schwerer als Luft.
Erste Hilfe
Nach Hautkontakt: Mit reichlich Wasser abwaschen.
Nach Augenkontakt: Mit reichlich Wasser bei geöffnetem Lidspalt mindestens 10 Minuten ausspülen. Sofort Augenarzt hinzuziehen.
Nach Einatmen: Frischluft.
Nach Verschlucken: Reichlich Wasser trinken, Erbrechen auslösen. Arzt hinzuziehen.
Nach Kleidungskontakt: Kontaminierte Kleidung entfernen.
Ersthelfer: siehe gesonderten Anschlag
Sachgerechte Entsorgung
Als halogenfreie, organische Lösemittelabfälle.
Beschreibung
Hexyl alcohol has a fruity odor and aromatic flavor. May be synthesized by reduction of n-caproic acid; the n-hexyl alcohol represents one of the 14 possible isomers of this alcohol.
Chemische Eigenschaften
Hexyl alcohol has an herbaceous, woody, fragrant, mild, sweet, green fruity odor and aromatic flavor.
Chemische Eigenschaften
Colourless liquid (odour recognition threshold 0.09ppm)
Chemische Eigenschaften
1-Hexanol is a liquid at room temperature.The absolute perceived concentration has been reported as 0.01 ppm, and the recognition level is 0.09 ppm .
Occurrence
Reported found among the constituents of several essential oils and aromas: apple, strawberry, tea, violet (leaves and flowers), Java citronella, Bourbon geranium, lavender, lavandin, spike, Litsea zeylanica; also identified in bitter orange. Also reported found in over 300 natural sources including apples, banana, sweet and sour cherry, citrus peel oils and juice, kumquat peel oil, berries, guava, grapes, raisin, melon, papaya, peach, pear, pineapple, asparagus, kohlrabi, cabbage, celery, cucumber, lettuce, leek, garlic, raw and cooked potato, sauerkraut, tomato, bell pepper, ginger, mint oils, mustard, breads, cheeses, butter, milk, fatty fish, meats, cognac, whiskies, rum, cider, grape wines, coffee, tea, cocoa, peanut oil, pecans, soybeans, nuts, coconut meat and milk, avocado, olive, passion fruit, plum, beans, mushrooms, starfruit, mango, fenugreek, sesame seed oil, figs, kelp, cardamom, coriander, gin, rice, fruit brandies, prickly pear, licorice, lovage corn oil, endive, truffles and other sources
Verwenden
1-Hexanol is used as a precursor to plasticizers, chemical intermediate for pharmaceuticals, perfume esters and antiseptics. Further, it serves as a perturbing agent on actomyosin adenosine triphosphatease. In addition to this, it is used to modulate the function of actomyosin motor.
Verwenden
1-Hexanol has been used as an odorant to study olfactory responses and to thin the dielectric layer of poly(4-vinylphenol) (PVP).
Verwenden
1-Hexanol was examined as a perturbing agent on actomyosin ATPase and and was found to modulate the function of actomyosin motor via intermediate-specific structural perturbation.
Vorbereitung Methode
1-Hexanol is commercially prepared from the addition of ethylene to triethylaluminum followed by oxidation. It is also produced from natural products derived from coconut or palm oils.
Definition
ChEBI: A primary alcohol that is hexane substituted by a hydroxy group at position 1.
synthetische
By reduction of n-caproic acid; the n-hexyl alcohol represents 1 of the 14 possible isomers of this alcohol
Aroma threshold values
Detection: 200 ppb to 2.5 ppm
Taste threshold values
Taste characteristics at 20 ppm: green, fruity, apple-skin and oily
Synthesis Reference(s)
Tetrahedron Letters, 30, p. 279, 1989 DOI: 10.1016/S0040-4039(00)95179-7
Allgemeine Beschreibung
1-Hexanol is an organic alcohol, which has application in the synthesis of antiseptics, fragrances, perfumes, etc. It is also used as a component of plasticizers.
Hazard
Combustible.
Health Hazard
Recommended Personal Protective Equipment: Chemical gloves; chemical goggles; Symptoms Following Exposure: Liquid causes eye burns and skin irritation. Breathing vapors is not expected to cause systemic illness; General Treatment for Exposure: In case of contact, immediately flush skin and eyes with plenty of water. Wash eyes at least 15 min. and get medical care; Toxicity by Inhalation (Threshold Limit Value): Data not available; Short-Term Inhalation Limits: Data not available; Toxicity by Ingestion: Grade 2, LD₅₀ = 0.5 to 5 g/kg (rat); Late Toxicity: Data not available; Vapor (Gas) Irritant Characteristics: Data not available; Liquid or Solid Irritant Characteristics: Causes smarting of the skin and first-degree burns on short exposure; may cause second-degree burns on long exposure; Odor Threshold: Data not available.
Health Hazard
Vapors of n-hexanol are irritant to the eyesand respiratory tract. Application of the liquid produced severe irritation in rabbits’eyes. It exhibits narcotic effects at high concentrations. The oral LD50 value in mice isin the range 2000 mg/kg.
Flammability and Explosibility
Flammable
Chemische Reaktivität
Reactivity with Water No reaction; Reactivity with Common Materials: No reactions; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.
mögliche Exposition
Human Data;Primary Irritant. Those using hexanol as a solvent or in thesynthesis of pharmaceuticals and textile chemicals. Alsousedas a plasticizer intermediate, specialty, ethoxylateintermediate, and a defoamer.
Erste Hilfe
If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek med-ical :attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, includ-ing resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medi-cal attention. Give large quantities of water and inducevomiting. Do not make an unconscious person vomit.
Carcinogenicity
1-Hexanol was not a skin tumor promoter when applied three times a week for 60 weeks to mice skin that had been initiated with dimethylbenz[a] anthracene.
Lager
Color Code- -Red: Flammability Hazard: Store ina flammable liquid storage area or approved cabinet awayfrom ignition sources and corrosive and reactive materials.Prior to working with hexanol you should be trained on itsproper handling and storage. Before entering confined spacewhere hexanol may be present, check to make sure that anexplosive concentration does not exist. Store in tightlyclosed containers in a cool, well-ventilated area away fromoxidizers，strong acids. Metal containers involving thetransfer of this chemical should be grounded and bonded.Where possible, automatically pump liquid from drums orother storage containers to process containers. Drums mustbe equipped with self-closing valves, pressure vacuumbungs, and flame arresters. Use only nonsparking tools andequipment, especially when opening and closing containersof this chemical. Sources of ignition, such as smoking andopen flames, are prohibited where this chemical is used,handled, or stored in a manner that could create a potentialfire or explosion hazard. Wherever this chemical is used,handled, manufactured, or stored, use explosion-proof elec-trical equipment and fittings. .
Versand/Shipping
This compound requires a shipping label of“FLAMM ABLE LIQUID. '”’It falls in Hazard Class 3 andPacking Group II.
läuterung methode
The commercial material usually contains other alcohols which are difficult to remove. A suitable method is to esterify with hydroxybenzoic acid, recrystallise the ester and saponify. [Olivier Recl Trav Chim, Pays-Bas 55 1027 1936.] Drying agents include K2CO3 and CaSO4, followed by filtration and distillation. (Some decomposition to the olefin occurs when Al amalgam is used as drying agent at room temperature, even if the amalgam is removed prior to distillation.) If the alcohol is required anhydrous, the redistilled material can be refluxed with the appropriate alkyl phthalate or succinate, as described under Ethanol. [Beilstein 1 IV 1694.]
Inkompatibilitäten
Incompatibilties:Formsexplosivemixturewithair.Incompatible with strong acids, caustics, aliphatic amines,lsocyanates, strong oxidizers.

1-Hexanol Upstream-Materialien And Downstream Produkte

1-Hexanol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

111-27-3, 1-Hexanol Verwandte Suche:

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