Uracil

Bezeichnung:Uracil

CAS-Nr66-22-8

Englisch Name:Uracil

CBNumberCB8376824

SummenformelC4H4N2O2

Molgewicht112.09

MOL-Datei66-22-8.mol

Synonyma

Uracil

Uracil physikalisch-chemischer Eigenschaften

Schmelzpunkt	>300 °C (lit.)
Siedepunkt	209.98°C (rough estimate)
Dichte	1.4421 (rough estimate)
Brechungsindex	1.4610 (estimate)
storage temp.	2-8°C
Löslichkeit	Aqueous Acid (Slightly), DMSO (Slightly, Heated, Sonicated), Methanol (Slightly)
Aggregatzustand	Crystalline Powder
pka	9.45(at 25℃)
Farbe	White to slightly yellow
Wasserlöslichkeit	SOLUBLE IN HOT WATER
Merck	14,9850
BRN	606623
Stabilität	Stable. Incompatible with strong oxidizing agents.
InChIKey	ISAKRJDGNUQOIC-UHFFFAOYSA-N
LogP	-1.037 (est)
CAS Datenbank	66-22-8(CAS DataBase Reference)
NIST chemische Informationen	Uracil(66-22-8)
EPA chemische Informationen	Uracil (66-22-8)

Sicherheit

Kennzeichnung gefährlicher	Xi
S-Sätze:	22-24/25
WGK Germany	2
RTECS-Nr.	YQ8650000
TSCA	Yes
HS Code	29335990

Gefahreninformationscode (GHS)

Uracil Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
Uracil is a pyrimidine base and a fundamental component of RNA where it binds to adenine via hydrogen bonds. It is converted into the nucleoside uridine through the addition of a ribose moiety, then to the nucleotide uridine monophosphate by the addition of a phosphate group.
Chemische Eigenschaften
Crystalline needles. Soluble in hot water, ammonium hydroxide, and other alkalies; insoluble in alcohol and ether.
Verwenden
Uracil metabolism levels may serve as a diagnostic for oral cancer. It was shown that measuring the overproduction of the metabolite uracil improves the diagnosis and prognosis of gingival buccal squamous cell carcinoma, one of the most common oral cancers in India. And about 83.09% of the tumour tissues showed significant changes in both uracil and pyrimidine metabolism. Higher levels of uracil in patients with lymph node metastases suggest that the metabolites may increase the cancer's ability to spread. It could also be used as a marker for recurrence follow-up, the researchers said.
Verwenden
antineoplastic
Verwenden
Uracil (Lamivudine EP Impurity F) is a nitrogenous base on RNA nucleosides.
Definition
uracil: A pyrimidine derivative andone of the major component bases ofnucleotides and the nucleic acidRNA.
Definition
A nitrogenous base that is found in RNA, replacing the thymine of DNA. It has a pyrimidine ring structure.
Definition
ChEBI: A common and naturally occurring pyrimidine nucleobase in which the pyrimidine ring is substituted with two oxo groups at positions 2 and 4. Found in RNA, it base pairs with adenine and replaces thymine during DNA transcription.
Allgemeine Beschreibung
Certified pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Uracil is one of the nucleotide bases of RNA. It is the precursor of DNA′s thymine. It acts like a carrier of genetic data and is hooked up with a ribose and three phosphates to form a ribonucleoside triphosphate once a human body produces nucleotides.
Sicherheitsprofil
Moderately toxic by intraperitoneal route. An experimental teratogen. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
läuterung methode
Uracil crystallises from water (m 339-341o) and m 338o after sublimation in high vacuum. Its solubility in H2O at 20o is 1g/300mL. [Beilstein 24 H 312, 24 I 312, 24 II 169, 24 III/IV 1193.]

Uracil Upstream-Materialien And Downstream Produkte

Uracil Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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