5-Methyluracil

Bezeichnung:5-Methyluracil

CAS-Nr65-71-4

Englisch Name:Thymine

CBNumberCB8854081

SummenformelC5H6N2O2

Molgewicht126.11

MOL-Datei65-71-4.mol

Synonyma

5-Methyluracil

5-Methyluracil physikalisch-chemischer Eigenschaften

Schmelzpunkt	~320 °C (dec.) (lit.)
Siedepunkt	234.21°C (rough estimate)
Dichte	1.3541 (rough estimate)
Brechungsindex	1.5090 (estimate)
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	DMSO (Slightly), Methanol (Slightly, Heated)
Aggregatzustand	Powder
pka	9.94(at 25℃)
Farbe	White
Wasserlöslichkeit	Soluble in hot water. Slightly soluble in alcohol.
Decomposition	335 °C
Merck	14,9398
BRN	607626
Stabilität	Stable. Incompatible with strong oxidizing agents.
InChIKey	RWQNBRDOKXIBIV-UHFFFAOYSA-N
LogP	-0.620
CAS Datenbank	65-71-4(CAS DataBase Reference)
NIST chemische Informationen	Thymine(65-71-4)
EPA chemische Informationen	Thymine (65-71-4)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36-36/37/38
S-Sätze:	22-24/25-37/39-26
WGK Germany	2
RTECS-Nr.	XP2100000
TSCA	Yes
HS Code	29335990

Gefahreninformationscode (GHS)

Thymine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36:Reizt die Augen.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
White, crystalline powder. Slightly soluble in hot water; insoluble in coldwater, alcohol; sparingly soluble in ether; readily soluble in alkalies.
Verwenden
Thymine is a nitrogenous base component in the nucleic acid of DNA.
Verwenden
A nucleobase found in deoxyribonucleic acids (DNA).
Verwenden
Thymine (Zidovudine EP Impurity C) is a nitrogenous base component in the nucleic acid of DNA.
Definition
thymine: A pyrimidine derivativeand one of the major componentbases of nucleotides and the nucleicacid DNA.
Definition
A nitrogenous base found in DNA. It has a PYRIMIDINE ring structure.
Definition
ChEBI: A pyrimidine nucleobase that is uracil in which the hydrogen at position 5 is replaced by a methyl group.
Synthesis Reference(s)
The Journal of Organic Chemistry, 25, p. 149, 1960 DOI: 10.1021/jo01071a612
Allgemeine Beschreibung
Thymine (Zidovudine Related Compound C) is a process related impurity of antiretroviral drug zidovudine. Zidovudine belongs to the class of drugs known as nucleoside reverse transcriptase inhibitors and is generally used in the prevention and treatment of HIV/AIDS.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Biochem/physiol Actions
Thymine used in studying DNA structure byirradtaion methods leading to cross-linking reactions and derivitizations. Thymine dimers are indicative of DNA damage. Thymine is used with metal (mercury) to form thymine?HgII?thymine (T?HgII?T) duplexes. Thymine starvation in bacteria leads to halt in DNA synthesis and is referred as thymine-less death.
läuterung methode
Crystallise thymine from EtOAc, 10% aqueous EtOH or water. It has m 318-320o after sublimation at 200o/12mm. Purify it by preparative (2mm thick) TLC plates of silica gel, eluting with ethyl acetate/isopropanol/water (75:16:9, v/v; RF 0.75). The desired spot is localated with a uv lamp, cut the band from the plate, place it in MeOH, shake and filter it through a millipore filter, then evaporate. [Infante et al. J Chem Soc, Faraday Trans 1 68 1586 1973, Beilstein 24 H 353, 24 I 330, 24 II 183, 24 III/IV 1292.]

Thymine Upstream-Materialien And Downstream Produkte

5-Methyluracil Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

65-71-4, Thymine Verwandte Suche:

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