Harnsure

Bezeichnung:Harnsure

CAS-Nr69-93-2

Englisch Name:Uric acid

CBNumberCB9681462

SummenformelC5H4N4O3

Molgewicht168.11

MOL-Datei69-93-2.mol

Synonyma

Harnsure

Harnsure physikalisch-chemischer Eigenschaften

Schmelzpunkt	>300 °C (lit.)
Siedepunkt	297.02°C (rough estimate)
Dichte	1,9 g/cm³
Brechungsindex	1.9900 (estimate)
storage temp.	Sealed in dry,2-8°C
Löslichkeit	Aqueous Base (Sparingly, Heated)
Aggregatzustand	crystalline
pka	3.89(at 12℃)
Farbe	White to off-white
Geruch (Odor)	Odorless
Wasserlöslichkeit	Soluble in 1M sodium hydroxide solution. Slightly soluble in water. Insoluble in ether and alcohol.
Merck	14,9875
BRN	156158
Stabilität	Stable. Incompatible with acids, bases, oxidising agents.
LogP	-1.730 (est)
CAS Datenbank	69-93-2(CAS DataBase Reference)
EPA chemische Informationen	Uric acid (69-93-2)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	33-36/37/38
S-Sätze:	24/25-36-26
WGK Germany	3
RTECS-Nr.	YU7050080
TSCA	Yes
HS Code	29339900
Toxizität	A nitrogenous end product and the principal excretory product of purine metabolism in mammals. In birds and reptiles, it is the principal end product of nitrogen metabolism in general. Defects in uric acid metabolism and excretion appear to be associated with a number of disease states, and it frequently occurs as a component of renal calculi. It has not been associated closely with toxic insults except in the case of lead poisoning. Lead causes an elevation in blood uric acid concentration (uric acidemia) and a decrease in uric acid excretion.

Gefahreninformationscode (GHS)

Uric acid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R33:Gefahr kumulativer Wirkungen.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
Uric acid (C5H4O3N4) is a white solid that is insoluble in cold water, alcohol, or ether and sparingly soluble in hot water. It acts as a weak dibasic acid, creating two series of salts, with most being very slightly soluble in water (except for lithium urate, which is soluble).
Occurrence
Uric acid is found in the urine, blood, and muscle juices of carnivorous animals (herbivorous animals secrete hippuric acid), in the excrement of birds, serpents and insects, and is an oxidation product of the complex nitrogenous compounds of the animal organism.
Verwenden
Uric Acid is a heterocyclcic compound that is created when purine nucleotides are broken down of by the human body. High blood concetration of Uric Acid is known as hyperuricemia and is often associated with a wide range of disorders and medical conditions such as gout, diabetes and metabolic syndrome. Uric acid may be a marker of oxidative stress and may have a potential therapeutic role as an antioxidant.
Definition
A nitrogen compound produced from purines. In certain animals (e.g. birds and reptiles), it is the main excretory product resulting from breakdown of amino acids. In humans, uric acid crystals in the joints are the cause of gout.
Definition
uric acid: The end product of purinebreakdown in most primates, birds,terrestrial reptiles, and insects andalso (except in primates) the majorform in which metabolic nitrogen isexcreted. Being fairly insoluble, uricacid can be expelled in solid form,which conserves valuable water inarid environments. The accumulationof uric acid in the synovial ?uidof joints causes gout.
Biochem/physiol Actions
Uric acid is an insoluble catabolite produced by adenine and guanine metabolism. Accumulation of uric acid leads to gout, hyperuricemia, arthritis and renal failure. Elevated uric acid levels contributes to hypertension and pathogenesis of cardiovascular disease. Low uric acid levels associated with Parkinson′s disease and multiple sclerosis, may elicit protective functionality. High levels of uric acid in patients with chronic obstructive pulmonary disease (COPD) may serve as potential marker for diagnosis.
Sicherheitsprofil
Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
läuterung methode
Crystallise uric acid from hot distilled H2O (the solubility in H2O is 1part/39,000parts at 18o and 1part/2,000parts at 100o). It is best purified by dissolving in an alkaline solution and acidifying with dilute HCl and drying it at 100o in a vacuum. [Bergmann & Dikstein J Am Chem Soc 77 691 1955, Lister Purines Part II, Fused Pyrimidines Brown Ed, Wiley-Interscience pp256-257 1971, ISBN 0-471-38205-1, Beilstein 26 H 513, 26 I 151, 26 II 293, 26 III/IV 2619.]
Einzelnachweise
Regulation of uric acid metabolism and excretion DOI:10.1002/RECL.19881071209
Purification of Laboratory Chemicals, Fourth Edition. By W. L. F. DOI:10.1002/RECL.19881071209
Van Nostrand’s Scientific Encyclopedia DOI:10.1007/978-1-4757-6918-0
The Facts on File Dictionary of Chemistry DOI:10.5860/choice.37-4227
A Dictionary of Chemistry (6th edition) DOI:10.1108/09504120910935291
Uric Acid in Inflammation and the Pathogenesis of Atherosclerosis DOI:10.3390/ijms222212394

Uric acid Upstream-Materialien And Downstream Produkte

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