Oxipurinol

Bezeichnung:Oxipurinol

CAS-Nr2465-59-0

Englisch Name:Oxipurinol

CBNumberCB4709190

SummenformelC5H4N4O2

Molgewicht152.11

MOL-Datei2465-59-0.mol

Synonyma

Oxipurinol

Oxipurinol physikalisch-chemischer Eigenschaften

Schmelzpunkt	300 °C
Siedepunkt	274.55°C (rough estimate)
Dichte	1.637
Brechungsindex	1.8500 (estimate)
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	Soluble in DMSO.
Aggregatzustand	Powder
pka	pKa 7.7 (Uncertain)
Farbe	Light yellow
BRN	139956
Stabilität	Hygroscoipic
CAS Datenbank	2465-59-0(CAS DataBase Reference)
EPA chemische Informationen	Oxypurinol (2465-59-0)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	36
WGK Germany	3
HazardClass	IRRITANT
HS Code	29335990

Gefahreninformationscode (GHS)

Oxipurinol Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
Off White Solid
Verwenden
Oxypurinol, an allopurinol metabolite, is used as an inhibitor to study the specificity and kinetics of of xanthine oxidase(s). Oxypurinol is also used as an anti-inflammatory agent via inhibition of xanthine oxidase.
Verwenden
4,6-Dihydroxy-1H-pyrazolo[3,4-d]pyrimidine is an inhibitor to study the specificity and kinetics of xanthine oxidase. It is also used as an anti-inflammatory agent via inhibition of xanthine oxidase.
Verwenden
A metabolite of Allopurinol.
Definition
ChEBI: A pyrazolopyrimidine that is 4,5,6,7-tetrahydro-H-pyrazolo[3,4-d]pyrimidine substituted by oxo groups at positions 4 and 6.
Biologische Aktivität
oxipurinol is a xanthine oxidoreductase inhibitor.xanthine oxidoreductase (xo), a complex molybdoflavoenzyme present in milk and many other tissues, has been studied for many years. xo is generally recognized as a critical enzyme in purine catabolism.
Biochem/physiol Actions
An allopurinol metabolite.
in vitro
allopurinol could be rapidly oxidized by xo to its active metabolite oxypurinol (both isosteres of hypoxanthine and xanthine, respectively), which also could inhibit xo. oxypurinol was identified as a noncompetitive inhibitor of xo; the formation of this compound was reported to be responsible for much of the pharmacological activity of allopurinol. moreover, both allopurinol and oxypurinol showed free radical scavenging effects in isolated hearts, and exerted cardioprotective effects despite no detectable xo activities [1].
in vivo
animal study found that in the vasculature of hypercholesterolemic rabbits, oxypurinol treatment led to a decrease in vascular free radical production [1].
Einzelnachweise
[1] p. pacher, a. nivorozhkin and c. szabó. therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol. pharmacological reviews 58(1), 87-114 (2006).
[2] day ro, graham gg, hicks m, mclachlan aj, stocker sl, williams km. clinical pharmacokinetics and pharmacodynamics of allopurinol and oxypurinol. clin pharmacokinet. 2007;46(8):623-44.

Oxipurinol Upstream-Materialien And Downstream Produkte

Oxipurinol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

2465-59-0, Oxipurinol Verwandte Suche:

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