Sulfadiazin Produkt Beschreibung

Sulfadiazine Struktur
68-35-9
  • CAS-Nr.68-35-9
  • Bezeichnung:Sulfadiazin
  • Englisch Name:Sulfadiazine
  • Synonyma:Sulfadiazin
    a306;A-306;SD-Na;rp2616;DIAZYL;Diazin;Trisem;Adiazin;RP 2616;s.n.112
  • CBNumber:CB4166214
  • Summenformel:C10H10N4O2S
  • Molgewicht:250.28
  • MOL-Datei:68-35-9.mol
Sulfadiazin physikalisch-chemischer Eigenschaften
Sicherheit
  • Kennzeichnung gefährlicher :Xn,Xi
  • R-Sätze: :22-36/37/38-42/43-43-42
  • S-Sätze: :26-36
  • RIDADR  :3249
  • WGK Germany  :3
  • RTECS-Nr. :WP1925000
  • F  :10
  • TSCA  :Yes
  • HazardClass  :6.1(b)
  • PackingGroup  :III
  • HS Code  :29335990

Sulfadiazine Chemische Eigenschaften,Einsatz,Produktion Methoden

  • R-Sätze Betriebsanweisung: R22:Gesundheitsschädlich beim Verschlucken.
    R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
    R42/43:Sensibilisierung durch Einatmen und Hautkontakt möglich.
  • S-Sätze Betriebsanweisung: S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
    S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
  • Chemische Eigenschaften White to slightly yellow crystalline pow
  • Verwenden Sulfonamide antibacterial.
  • Verwenden DMSO soluble potent immunosuppressant, neuroprotective neuroregenerative, in vitro T cell proliferation blocker. disrupts calcineurin-mediated signal transduction in T lymphocytes
  • Definition ChEBI: A sulfonamide consisting of pyrimidine with a 4-aminobenzenesulfonamido group at the 2-position.
  • Trademarks Coco-Diazine (Lilly); Eskadiazine (SmithKline Beecham).
  • Antimicrobial activity Sulfadiazine is somewhat more active than other sulphonamides.
  • Allgemeine Beschreibung Sulfadiazine’s plasma half-life is 17 hours. It is a white,odorless crystalline powder soluble in water to the extentof 1:8,100 at 37°C and 1:13,000 at 25°C, in human serumto the extent of 1:620 at 37°C, and sparingly soluble in alcoholand acetone. It is readily soluble in dilute mineralacids and bases. Its pKa is 6.3.
  • Pharmazeutische Anwendungen Sulfadiazine is almost insoluble in water and unstable on exposure to light. It is administered orally or, as the sodium salt, by intravenous injection. It is a component of several multi-ingredient preparations. Its low solubility in urine led to its general replacement by other compounds. The intravenous solution is highly alkaline and should not be given by any other route.
  • Pharmakokinetik Oral absorption: Very good
    Cmax 3 g oral: c. 50 mg/L after 3–4 h
    Plasma half-life :7–12 h
    Volume of distribution: 0.36 L/kg
    Plasma protein binding: c. 40%
    Absorption and distribution
    Adequate blood concentrations are easily achieved and maintained after oral administration. It is well distributed and penetrates in therapeutic concentrations into the CSF, but because of resistance it is no longer the drug of choice in meningitis. It crosses the placenta and enters breast milk to achieve concentrations around 20% of plasma levels.
    Metabolism and excretion
    Sulfadiazine is subject to acetylation in the liver. The acetyl derivative lacks antibacterial activity and is excreted more slowly (half-life 8–18 h). Parent compound and metabolite are both excreted mainly by glomerular filtration.
  • Clinical Use Urinary tract infection
    Nocardiasis
    Chancroid
    Toxoplasmosis (in combination with pyrimethamine)
    Meningococcal infections
    Prophylaxis of rheumatic fever
  • Nebenwirkungen In addition to side effects common to the group, sulfadiazine inhibits the metabolism of phenytoin. The risk of crystalluria can be reduced by high fluid intake and alkalization of the urine.
  • Sicherheitsprofil Poison by intravenous route. Moderately toxic by ingestion and intraperitoneal routes. Human systemic effects by ingestion: hematuria, anuria, general anesthesia, gastrointestinal effects. Experimental teratogenic and reproductive effects. When heated to decomposition it emits very toxic fumes of NOx and SOx.
Sulfadiazine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Sulfadiazin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
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68-35-9, Sulfadiazine Verwandte Suche:
  • 4-amino-N-2-pyrimidinyl
  • 4-Amino-N-(2-pyrimidinyl)benzenesulfonamide, N1-(Pyrimidin-2-yl)sulfanilamide
  • Sulfadiazine zinc salt
  • Eksadiazine
  • 4-azanyl-N-pyrimidin-2-yl-benzenesulfonamide
  • Sulfadiazine Base & Sodium
  • Sulfadiazine,4-Amino-N-(2-pyrimidinyl)benzenesulfonamide, N1-(Pyrimidin-2-yl)sulfanilamide
  • Sulfadiazine (200 mg)
  • Sulfadiazine,(S)
  • -AMino-N-2-pyriMidinylbenzenesulfonaMide
  • 4-Amino-N-(2-pyrimidinyl)benzenesulfonamide N-(2-Pyrimidinyl)sulfanilamide
  • 2-sulfanilamidopyrimidin
  • 2-sulfanilamido-pyrimidin
  • 2-Sulfanilylaminopyrimidine
  • 2-Sulfapyrimidine
  • 4-Amino-N-2-pyrimidinylbenaenesulfonamide
  • 4-amino-n-2-pyrimidinyl-benzenesulfonamid
  • a306
  • A-306
  • Adiazin
  • Benzenesulfonamide, 4-amino-N-2-pyrimidinyl-
  • benzenesulfonamide,4-amino-N-2-pyrimidinyl-
  • Coco-Diazine
  • Codiazine
  • Pyrimidine, 2-sulfanilamido-
  • Quadetts
  • Quadramoid
  • RP 2616
  • rp2616
  • S. N. 112
  • s.n.112
  • Sanodiazine
  • SD-Na
  • Spofadrizine
  • Sulfacombin
  • Sulfadiazene
  • Sulfadiazinezinesalt
  • Sulfanilamide, N1-2(1H)-pyrimidinylidene-
  • Sulfanilamide, N1-2-pyrimidinyl-
  • sulfanilamide,n(sup1)-2(1h)-pyrimidinylidene
  • SULFADIAZINE BP
  • 4-Amino-N-(2-pyrimidinyl)benzenesulphonamide
  • sulfadiazine solution
  • SULFADIAZINE,POWDER,USP
  • SULFADIAZINE(SD) (NDC:55631-2004)
  • Sulphadiazine/Sulfadiazine
  • SULFADIAZINE USP
  • SULFADIAZINE (SULPHADIAZINE)
  • N-(2-Pyrimidinyl)sulfanilamide
  • CAS 68-35-9 Sulfadiazine
  • sulfadiazine Solution, 100ppm
  • Sulfadiazine for identification of impurity F
  • SulfadiazineUSP, 98.0-102.0% (Assay, anhydrous basis)
  • PYRIMAL
  • N1-(PYRIMIDIN-2-YL)SULFANILAMIDE
  • N1-2-PYRIMIDINYLSULFANILAMIDE
  • SULFADIAZIN
  • SULFADIAZINE