5-Bromuracil

Bezeichnung:5-Bromuracil

CAS-Nr51-20-7

Englisch Name:5-Bromouracil

CBNumberCB6388195

SummenformelC4H3BrN2O2

Molgewicht190.98

MOL-Datei51-20-7.mol

Synonyma

5-Bromuracil

5-Bromuracil physikalisch-chemischer Eigenschaften

Schmelzpunkt	>300 °C (lit.)
Dichte	1.8710 (rough estimate)
Brechungsindex	1.6200 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Löslichkeit	<1g/l
pka	6.77±0.10(Predicted)
Aggregatzustand	Solid
Farbe	White
Wasserlöslichkeit	SOLUBLE IN COLD WATER
Merck	14,1445
BRN	127176
InChIKey	LQLQRFGHAALLLE-UHFFFAOYSA-N
CAS Datenbank	51-20-7(CAS DataBase Reference)
NIST chemische Informationen	5-Bromouracil(51-20-7)
EPA chemische Informationen	5-Bromouracil (51-20-7)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22-46
S-Sätze:	36/37-53-45-24/25
WGK Germany	3
RTECS-Nr.	YQ9060000
TSCA	Yes
HS Code	29335995
Giftige Stoffe Daten	51-20-7(Hazardous Substances Data)

Gefahreninformationscode (GHS)

5-Bromouracil Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R46:Kann vererbbare Schäden verursachen.
S-Sätze Betriebsanweisung:
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
5-bromouracil (5-BU) is a uracil derivative, and its 5' position of the pyrimidine ring is halogenated. If 5-BU is incorporated into DNA in place of thymine, the tautomeric shift will occur, and the 5-BU will base pair with guanine. After the replication, an A-T to G-C transition occurs. Furthermore, the presence of 5-BU within DNA increases the sensitivity of the molecule to UV light. 5-BU is structurally similar to thymine. Therefore, it is considered a thymine analog and base-pairs normally with adenine. It is rarely present in its enol form, where its base pairs with guanine. 5-Bromouracil treats neoplasms in the form of its nucleoside, 5-bromo-2-deoxy-uridine[1-2].
Chemische Eigenschaften
Prisms from H 2 O.
Verwenden
A major chemical mutagen. Incorporates into DNA, altering base-pair sequencing by replacing thymine
Definition
ChEBI: A pyrimidine having keto groups at the 2- and 4-positions and a bromo group at the 5-position.
Allgemeine Beschreibung
White powder.
Air & Water Reaktionen
Insoluble in water.
Reaktivität anzeigen
A halogenated amide. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).
Hazard
Moderately toxic, alters DNA by replacing thymine.
Health Hazard
ACUTE/CHRONIC HAZARDS: When heated to decomposition 5-Bromouracil emits very toxic fumes of bromide ion and NOx.
Brandgefahr
Flash point data for 5-Bromouracil are not available, but 5-Bromouracil is probably combustible.
Sicherheitsprofil
Moderately toxic by intraperitoneal route. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of Brand NOx.
Einzelnachweise
[1] Bhagavan, N. and C. Ha. “Chapter 21 – Structure and Properties of DNA.” (2015): 381-400.
[2] Shen, Chang-Hui. “Nucleic Acid-Based Cellular Activities.” Diagnostic Molecular Biology 25 1 (2019): 27-57.

5-Bromouracil Upstream-Materialien And Downstream Produkte

5-Bromuracil Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

51-20-7, 5-Bromouracil Verwandte Suche:

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