Cinchocainhydrochlorid

Bezeichnung:Cinchocainhydrochlorid

Englisch Name:Dibucaine hydrochloride

CBNumberCB8358372

SummenformelC20H30ClN3O2

Molgewicht379.92

Synonyma

Cinchocainhydrochlorid

Cinchocainhydrochlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	99-101 °C(lit.)
Dichte	1.1338 (rough estimate)
Brechungsindex	1.5400 (estimate)
storage temp.	Refrigerator
Löslichkeit	DMSO (Slightly), Methanol (Slightly)
Aggregatzustand	Solid
Farbe	Hygroscopic crystals
PH	pH(20g/l,25℃) : 5.0～6.0
Wasserlöslichkeit	Freely soluble in water, alcohol, acetone, or chloroform
Merck	13,3057
Stabilität	Stable. Incompatible with strong oxidizing agents. Protect from moisture.
InChI	InChI=1S/C20H29N3O2.ClH/c1-4-7-14-25-19-15-17(16-10-8-9-11-18(16)22-19)20(24)21-12-13-23(5-2)6-3;/h8-11,15H,4-7,12-14H2,1-3H3,(H,21,24);1H
InChIKey	IVHBBMHQKZBJEU-UHFFFAOYSA-N
SMILES	C12C=CC=CC1=NC(OCCCC)=CC=2C(=O)NCCN(CC)CC.Cl
CAS Datenbank	61-12-1(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22-41
S-Sätze:	26-39
WGK Germany	3
RTECS-Nr.	GD3325000
HS Code	2933492250
Toxizität	eye-rbt 2% SEV ARZNAD 8,181,58

Gefahreninformationscode (GHS)

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R41:Gefahr ernster Augenschäden.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S39:Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
white powder
Verwenden
Anesthetic (local).
Verwenden
Dibucaine HCl is an amide-like quinoline derivative and is one of the most potent and longest acting of the commonly used local anesthetics.
Verwenden
Cinchocaine is used as an anaesthetic agent for spinal anaesthesia; a component in rectal medications used in inflammation of the anus and for the symptomatic treatment of hemorrhoids and fissures in the anus; local anesthetic agent.
Definition
ChEBI: The monohydrochloride salt of cinchocaine. It is used in creams, ointments and suppositories for temporary relief of pain and itching associated with skin and anorectal conditions.
Trademarks
Nupercaine (Novartis).
Kontakt-Allergie
Dibucaine hydrochloride is an amide group local anesthetic that can induce allergic contact dermatitis.
Sicherheitsprofil
Poison by ingestion,subcutaneous, intravenous, intraspinal, parenteral, andintraperitoneal routes. Mutation data reported. A severeeye irritant. A local anesthetic. When heated todecomposition it emits very toxic fumes of HCl and NOx