2-(Diphenylmethoxy)-N,N-dimethyl-ethanamin-hydrochlorid

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

Diphenhydramine Hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

• R-Sätze Betriebsanweisung:

  R22:Gesundheitsschädlich beim Verschlucken.

• S-Sätze Betriebsanweisung:

  S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

• Beschreibung

  Diphenhydramine is most commonly used as a first-generation antihistamine and is globally marketed in various brand formulations (Benadryl®, Unisom®, Tylenol®, Zzzquil®). It competitively blocks H1 receptors, thereby preventing the actions of histamine on bronchial smooth muscle, capillaries, and gastrointestinal (GI) smooth muscle. This prevents histamine-induced bronchoconstriction, vasodilation, increased capillary permeability, and GI smooth muscle spasms. Diphenhydramine exhibits anti-tussive, antiemetic, sedative, anti-allergic, and anticholinergic activities.

• Chemische Eigenschaften

  White or almost white, crystalline powder. odorless and has a bitter, numbing taste. soluble in water and in alcohol.

• Originator

  Benadryl,Parke Davis,US,1946

• Verwenden

  Diphenhydramine is a H1-histamine receptor antagonist with anticholinergic (drying) and sedative side effects. It is categorized as an antihistaminic; sedative, hypnotic, treatment of allergic. It is used to treat allergy and cold symptoms such as sneezing, runny nose, watery eyes, urticaria (hives), skin rash, and pruritus (itchy skin).

• Application

  Diphenhydramine hydrochloride is used as an antihistamine and for its antieholinergie (drying) and sedative effects; for allergic conjunctivitis due to foods; for mild, uncomplicated allergic skin manifestations of urticaria and angioedema; for amelioration of allergic reactions to blood or plasma; for dermatographism; in therapy for anaphylaetie reactions adjunctive to epinephrine and other standard measures after the acute manifestations have been controlled; for active and prophylactie treatment of motion sickness; for parkinsonism; an antiemetic; has local anesthetic properties; in preparations for the relief of cough; in the prevention and treatment of radiation sickness, nausea and vomiting; for treatment of allergie cheilitis and stomatitis.

• synthetische

  Diphenhydramine Hydrochloride synthesis is a four-step sequence starting with a Grignard reaction.
  
  Synthesis of Diphenhydramine Hydrochloride 6.
  A) modified synthetic route to diphenhydramine hydrochloride.
  B) Sequence of unit operations required for the synthesis. The dotted boxes denote the four stages of the synthesis. DMAE: dimethylaminoethanol.
  Organic synthesis in a modular robotic system driven by a chemical programming language

• Definition

  ChEBI: Diphenhydramine Hydrochloride is the hydrochloride salt form of diphenhydramine, an ethanolamine and first-generation histamine antagonist with anti-allergic activity.

• Trademarks

  Benadryl (Parke-Davis).

• Therapeutic Function

  Antihistaminic

• Allgemeine Beschreibung

  Diphenhydramine hydrochloride(Benadryl), is an oily, lipid-soluble free base available as the bitter-tasting hydrochloride salt, which is a stable, White or almost-white crystalline powder. Odorless with a bitter numbing taste. soluble in water (1:1), alcohol (1:2) and chloroform (1:2). The salt has a pKa value of 9, and a 1% aqueous solution has a pH of about 5.

• Air & Water Reaktionen

  Water soluble. Aqueous solutions are acidic.

• Reaktivität anzeigen

  N-(2-Diphenylmethoxyethyl)-N,N-dimethylamine hydrochloride gives acidic solutions in water. Neutralizes bases. May react with strong oxidizing and strong reducing agents. May catalyze organic reactions. Slowly darkens on exposure to light.

• Health Hazard

  Potentially. If taken in large quantities, diphenhydramine can cause severe agitation and confusion, fever, skin flushing, problems with vision, dry mouth, dry eyes, and inability to sweat. Overdoses can lead to high heart rates, abnormal heart rhythms, seizures, and death.
  If given to elderly patients, diphenhydramine can cause confusion and agitation. Because of this, diphenhydramine is not recommended in elderly patients for insomnia or treatment for the common cold; though it should still be given in cases of allergic reaction.

• Biologische Aktivität

  Diphenhydramine (DPH) is a first generation antihistamine that is a potent antagonist of the histamine H1 receptor (Ki = 11.7 nM using human recombinant receptors). DPH readily crosses the blood-brain barrier and produces diverse cognitive and psychomotor effects. DPH also antagonizes muscarinic cholinergic receptors (Kis = 100 to 260 nM for M1-M5), increasing the range of central nervous system effects and applications.

• Biochem/physiol Actions

  Diphenhydramine hydrochloride (DPH) is an antihistaminic agent that relieves symptoms of hypersensitive reactions. It exhibits antimuscarinic and marked sedative effects. DPH is also used to prevent nausea, vomiting and vertigo of various causes. In addition, it acts as a potential therapeutic for insomnia.

• Kontakt-Allergie

  This antihistaminic drug with sedative properties is mainly sold over the counter. It can be used both topically (treatment of pruritis) and orally for its antiallergic, antiemetic, sedative, and anticough properties. Allergic or photoallergic contact dermatitis and fixeddrug eruption seem to be rare.

• Sicherheitsprofil

  Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by ingestion or skin contact: arrhythmias, ataxia, blood pressure elevation, convulsions, distorted perceptions, eye effects, and hallucinations. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits very toxic fumes of NO, and HCl. See also ESTERS and ETHERS.

• Synthese

  

  58-73-1

  

  147-24-0

  The general procedure for synthesizing 2-(phenylmethoxy)-N,N-dimethylethylamine hydrochloride using benzylamine as a starting material was as follows: first, benzylamine was prepared according to the method described in any one of embodiments 6-9. Subsequently, the prepared benzylamine was dissolved in a 5.0 mol/L ethanol solution. Next, dry hydrogen chloride gas was passed into the solution until saturation and stirred continuously for 1 hour at room temperature. Finally, the solvent was removed by distillation under reduced pressure to obtain the target product benzylamine hydrochloride.

• Veterinary Drugs and Treatments

  In veterinary medicine, diphenhydramine is used principally for its antihistaminic effects, but also for other pharmacologic actions. Its sedative effects can be of benefit in treating the agitation (pruritus, etc.) associated with allergic responses. It has also been used for treatment and prevention of motion sickness and as an antiemetic in small animals. It has been suggested for use as adjunctive treatment of aseptic laminitis in cattle and it may be useful as an adjunctive treatment for feline pancreatitis. For other suggested uses, refer to the Dosage section below.

• Lager

  Desiccate at RT

• Filter für giftige stoffe

  The CORRECTED Screening Level for DIPHENHYDRAMINE HCL (CAS # 147-24-0) has been set at 50 μg/m3 (annual average) based on the particulate standard.

• Einzelnachweise

  [1] Patent: CN107673945, 2018, A. Location in patent: Paragraph 0028; 0029; 0030; 0031

Diphenhydramine Hydrochloride Upstream-Materialien And Downstream Produkte

2-(Diphenylmethoxy)-N,N-dimethyl-ethanamin-hydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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