Benzhydrylalkohol

Bezeichnung:Benzhydrylalkohol

CAS-Nr91-01-0

Englisch Name:Benzhydrol

CBNumberCB8417044

SummenformelC13H12O

Molgewicht184.24

MOL-Datei91-01-0.mol

Synonyma

Benzhydrylalkohol

Benzhydrylalkohol physikalisch-chemischer Eigenschaften

Schmelzpunkt	65-67 °C (lit.)
Siedepunkt	297-298 °C (lit.)
Dichte	1.0120 (rough estimate)
Dampfdruck	0.000076 hPa (20 °C)
Brechungsindex	1.5727 (estimate)
Flammpunkt	160 °C
storage temp.	Store below +30°C.
Löslichkeit	0.52g/l insoluble
Aggregatzustand	Crystalline Solid
pka	13.55±0.20(Predicted)
Farbe	White to beige
Geruch (Odor)	at 100.00 %. weedy green rose
Geruchsart	green
Wasserlöslichkeit	Slightly soluble in water.
Merck	14,1090
BRN	1424379
Stabilität	Stable. Combustible. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides, acids.
LogP	2.670
CAS Datenbank	91-01-0(CAS DataBase Reference)
NIST chemische Informationen	Benzenemethanol, «alpha»-phenyl-(91-01-0)
EPA chemische Informationen	Benzenemethanol, .alpha.-phenyl- (91-01-0)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36-24/25
WGK Germany	2
RTECS-Nr.	DC7452000
Hazard Note	Irritant
TSCA	Yes
HS Code	29062900
Toxizität	LD50 orally in Rabbit: 5000 mg/kg LD50 dermal Rabbit > 5000 mg/kg

Gefahreninformationscode (GHS)

Benzhydrol Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
off-white powder or White or colorless crystals. M.P. 69℃. B.p. 281℃. Practically insoluble in water, soluble in alcohol, miscible with oils. The crystals have a very faint musty-rosy odor, somewhat similar to that of Benzophenonc and Trichloromethyl phenyl carbinyl acetate.
Verwenden
1. Benzhydrols are industrially important compounds. On oxidation Benzhydrols yields Benzophenone, which are useful synthones for fullerenes, bioactive oxygen heterocycles, dyes and medicines. Various Cr (VI) and other oxidizing agents are used for oxidizing benzhydrol.
2. Benzhydrol is widely used as intermediates in pharmaceuticals (including antihistamines), agrochemicals, perfumes and other organic compounds. It is used as a fixative in the perfume industry. It is involved in polymerization reaction as a terminating group. It is used as precursor to prepare modafinil, benztropine and diphehydramine.
3. Intermediate in the preparation of Modafinil (M482500).
Verwenden
Anchoring of carboxylic acids and alcohols
synthetische
By reduction of Benzophenone, e.g. with zinc in aqueous alkali.
Definition
ChEBI: Diphenylmethanol is a secondary alcohol that is diphenylmethane which carries a hydroxy group at position 1. It has a role as a rat metabolite, a bacterial xenobiotic metabolite, a human xenobiotic metabolite and a human urinary metabolite. It is a secondary alcohol and a member of benzyl alcohols. It derives from a hydride of a diphenylmethane.
Reaktionen
Benzhydrol is oxidized to benzophenone, by sodium hypochlorite (commonly known as bleach) in the presence of a phase-transfer catalyst.
Synthesis: In a 20-mL green capped vial, place 1.5 mL of ethyl acetate, 100 mg (0.54 mmol) of benzhydrol and a few drops of methyltricaprylammonium chloride solution (Stark's catalyst or tricaprylmethylammonium chloride). Add a half-inch magnetic stirring bar, and stir until all reagents are dissolved. Cool the solution in an ice bath and add 2 mL of 5% NaOCl (aq) (bleach) dropwise using a 2.5- mL syringe. After the addition of the hypochlorite is complete, allow the reaction to stir for five minutes in the ice-water bath and then stir for a period of one hour at room temperature.

Reduction of benzophenone to benzhydrol.
4MPDC (4-Methyl pyridinium di chromate) is used as oxidizing agent to oxidize benzhydrol. PDC is a mild and selective oxidizing agent and is soluble in water and many organic solvents. Therefore, advantage over inorganic dichromate.
Synthesis Reference(s)
Canadian Journal of Chemistry, 50, p. 3058, 1972 DOI: 10.1139/v72-485
Journal of the American Chemical Society, 55, p. 391, 1933 DOI: 10.1021/ja01328a057
Tetrahedron Letters, 29, p. 139, 1988 DOI: 10.1016/S0040-4039(00)80036-2
Allgemeine Beschreibung
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
läuterung methode
Crystallise benzhydrol from hot H2O or pet ether (b 60-70o), pet ether containing a little *benzene, from CCl4, or EtOH (1mL/g). An additional purification step includes passage of a *benzene solution through an activated alumina column. It sublimes in a vacuum. Also recrystallise it three times from MeOH/H2O [Naguib J Am Chem Soc 108 128 1986]. [Beilstein 6 IV 4648.]

Benzhydrol Upstream-Materialien And Downstream Produkte

Benzhydrylalkohol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

91-01-0, Benzhydrol Verwandte Suche:

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