Orphenadrinhydrochlorid

Bezeichnung:Orphenadrinhydrochlorid

CAS-Nr341-69-5

Englisch Name:ORPHENADRINE HYDROCHLORIDE

CBNumberCB6782740

SummenformelC18H24ClNO

Molgewicht305.84

MOL-Datei341-69-5.mol

Synonyma

Orphenadrinhydrochlorid

Orphenadrinhydrochlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	159.0 to 164.0 °C
Siedepunkt	-195 °C
Dichte	0.295 g/cm3
storage temp.	2-8°C
Löslichkeit	Freely soluble in water and in ethanol (96 per cent).
Farbe	Crystals
BRN	3745818
Stabilität	Stable. Incompatible with strong oxidizing agents.
CAS Datenbank	341-69-5(CAS DataBase Reference)
EPA chemische Informationen	Orphenadrine hydrochloride (341-69-5)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22
S-Sätze:	36
RIDADR	3249
WGK Germany	3
RTECS-Nr.	KR6300000
HazardClass	6.1(b)
PackingGroup	III
Toxizität	LD50 oral in rat: 255mg/kg

Gefahreninformationscode (GHS)

ORPHENADRINE HYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
White or almost white, crystalline powder.
Verwenden
Antihistaminic;H1 antogonist
Definition
ChEBI: A hydrochloride comprising equimolar amounts of ophenadrine and hydrogen chloride.
Allgemeine Beschreibung
Odorless white or almost white crystalline powder. pH (aqueous solution) about 5.5. Bitter numbing taste.
Air & Water Reaktionen
May be sensitive to prolonged exposure to light and air. Water soluble.
Reaktivität anzeigen
ORPHENADRINE HYDROCHLORIDE is incompatible with strong oxidizers.
Brandgefahr
Flash point data for ORPHENADRINE HYDROCHLORIDE are not available; however, ORPHENADRINE HYDROCHLORIDE is probably combustible.
Biochem/physiol Actions
Muscarinic receptor antagonist; H1 histamine receptor antagonist; muscle relaxant. Orphenadrine has also been reported to inhibit the noradrenergic transporter and to block the NMDA receptor ion channel.
Clinical Use
Anti-muscarinic:
Parkinsonism
Drug induced extra-pyramidal symptoms
Sicherheitsprofil
Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Human systemic effects: mydriasis @updlaryd ilation), hallucinations, distorted perceptions, pulse rate increase, intracranial pressure increase. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and HCl
Stoffwechsel
Orphenadrine is almost completely metabolised to at least 8 metabolites in the liver.
It is mainly excreted in the urine as metabolites and small amounts of unchanged drug

Orphenadrinhydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

341-69-5, ORPHENADRINE HYDROCHLORIDE Verwandte Suche:

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