Orphenadrin

Bezeichnung:Orphenadrin

CAS-Nr83-98-7

Englisch Name:Orphenadrine

CBNumberCB1397020

SummenformelC18H23NO

Molgewicht269.38

MOL-Datei83-98-7.mol

Synonyma

Orphenadrin

Orphenadrin physikalisch-chemischer Eigenschaften

Schmelzpunkt	25°C
Siedepunkt	bp12 195°
Dichte	1.0278 (rough estimate)
Brechungsindex	1.5740 (estimate)
pka	pKa 8.4 (Uncertain)
Aggregatzustand	Solid
Wasserlöslichkeit	1.801mg/L(22.5 ºC)
CAS Datenbank	83-98-7

Sicherheit

RIDADR	1851
HazardClass	6.1(b)
PackingGroup	III
Giftige Stoffe Daten	83-98-7(Hazardous Substances Data)
Toxizität	LD50 oral in mouse: 125mg/kg

Gefahreninformationscode (GHS)

Orphenadrine Chemische Eigenschaften,Einsatz,Produktion Methoden

Originator
Norflex,Riker,US,1959
Verwenden
Relaxant (skeletal muscle); antihistaminic.
Definition
ChEBI: A tertiary amino compound which is the phenyl-o-tolylmethyl ether of 2-(dimethylamino)ethanol.
Manufacturing Process
As described in US Patent 2,567,351, o-methylbenzhydryl bromide is added slowly to β-dimethylaminoethanol at refluxing temperature. After the addition has been completed the mixture is refluxed and stirred for an additional 16 hours. The mixture is cooled and the bottom layer consisting of the crude hydrobromide salt of β-dimethylaminoethanol is drawn off. The excess amino alcohol is distilled from the upper layer in vacuo and the residue is reacted with citric acid.
Trademarks
Norflex (3M Pharmaceuticals).
Therapeutic Function
Muscle relaxant
Enzyminhibitor
This muscle relaxant and antihistaminic agent (FWfree-base = 269.39 g/mol; CAS 83-98-7) is both a muscarinic and histamine H1 receptor antagonist that also inhibits some cytochrome P450 systems. Classified as an anticholinergic drug (with 58% as potent as atropine) and an ethanolamineclass antihistamine, it also inhibits the noradrenergic transporter and NMDA receptor ion channel (Ki ≈ 6 μM). Commercially available as either the hydrochloride or citrate salt, orphenadrines used to relieve pain of muscle injuries, such as strains and sprains. Target(s): aldehyde oxidase; CYP1A2; CYP2A6; CYP3A4; CYP2B; CYP2B6; CYP2C9; CYP2C19; CYP2D6; histamine H1 receptor; N-methyl-D-aspartate (NMDA) receptor; muscarinic receptor; noradrenaline reuptake.

Orphenadrine Upstream-Materialien And Downstream Produkte

Orphenadrin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

83-98-7, Orphenadrine Verwandte Suche:

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