Cinchocain

Bezeichnung:Cinchocain

CAS-Nr85-79-0

Englisch Name:Cinchocaine

CBNumberCB1396856

SummenformelC20H29N3O2

Molgewicht343.46

MOL-Datei85-79-0.mol

Synonyma

Cinchocain

Cinchocain physikalisch-chemischer Eigenschaften

Schmelzpunkt	64°
Siedepunkt	478.73°C (rough estimate)
Dichte	1.1145 (rough estimate)
Brechungsindex	1.6300 (estimate)
storage temp.	Store at -20°C
Löslichkeit	DMSO:45.0(Max Conc. mg/mL);131.02(Max Conc. mM)
pka	pKa -5.3(aq. H2SO4) (Uncertain)
Aggregatzustand	Solid:particulate/powder
Wasserlöslichkeit	68.01mg/L(temperature not stated)
InChI	InChI=1S/C20H29N3O2/c1-4-7-14-25-19-15-17(16-10-8-9-11-18(16)22-19)20(24)21-12-13-23(5-2)6-3/h8-11,15H,4-7,12-14H2,1-3H3,(H,21,24)
InChIKey	PUFQVTATUTYEAL-UHFFFAOYSA-N
SMILES	N1C2C(=CC=CC=2)C(C(NCCN(CC)CC)=O)=CC=1OCCCC
LogP	4.4 at 25℃ and pH7
CAS Datenbank	85-79-0(CAS DataBase Reference)
NIST chemische Informationen	Dibucaine(85-79-0)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22-41
S-Sätze:	26-39
RTECS-Nr.	GD3150000
Giftige Stoffe Daten	85-79-0(Hazardous Substances Data)

Gefahreninformationscode (GHS)

Cinchocaine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R41:Gefahr ernster Augenschäden.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S39:Schutzbrille/Gesichtsschutz tragen.
Originator
Cincain,Ophtha
Verwenden
Cinchocaine is a local anesthesic,used for Na⁺channel blocker.
Definition
ChEBI: A monocarboxylic acid amide that is the 2-(diethylamino)ethyl amide of 2-butoxyquinoline-4-carboxylic acid. One of the most potent and toxic of the long-acting local anesthetics, its parenteral use was restricted to spinal anesthesia. It is now generally o ly used (usually as the hydrochloride) in creams and ointments and in suppositories for temporary relief of pain and itching associated with skin and anorectal conditions.
Manufacturing Process
A benzene solution of 2.2 parts of α-chloro-γ-quinoline-carboxylic acid chloride is gradually mixed, while cooling, with 2.3 parts of unsymmetrical diethylethylenediamine. When the reaction is at an end the solution is washed with water and the new base extracted by means of hydrochloric acid. The base is precipitated by means of sodium carbonate and extracted with benzene. The solvent is distilled and the base recrystallized from petroleum ether. The α-chloro-γ-quinoline-carboxylic acid diethyl-amino-ethylene amide forms colorless lamina crystals of melting point 74°C. With acids the base forms neutral salts soluble in water.
A solution of 2.5 parts of sodium in n-butylalcohol is boiled with 30 parts of α- chloro-γ-quinoline-carboxylic acid diethyl-amino-ethylene-amide in a reflux apparatus, and when the reaction is over the excess of butylalcohol is distilled. The remaining base is taken up with ether; the solution is washed with water and dried. The solvent is then distilled. The α-n-butoxy-γ-quinolinecarboxylic acid diethyl-amino-ethylene-amide forms as colorless crystals, after recrystallization from petroleum ether melting point of it 64°C.
In practice it is usually used as hydrochloride.
Trademarks
Nupercaine (Novartis).
Therapeutic Function
Local anesthetic
Allgemeine Beschreibung
Articaine has a secondary nitrogen with a pKa of 7.8. It containsan aromatic thiophene ring bioisostere of the phenylring found in most other amide anesthetics. The log P of abenzene ring is 2.13 and the thiophene ring log P is 1.81,thus the thiophene ring is more hydrophilic than a phenylring. Although the thiophene ring has less lipid solubilitythan a phenyl ring, articaine is a lipid-soluble compound dueto the propylamine, the branched methyl and the substitutionson the thiophene ring. The onset of action of articaineis similar to lidocaine’s onset of action.
Kontakt-Allergie
Dibucaine hydrochloride is an amide group local anesthetic that can induce allergic contact dermatitis.
Clinical Use
Articaine is availablein a 4% solution with epinephrine for use in infiltrationand nerve block anesthesia.Articaine is metabolized rapidly via plasma and tissuecarboxyesterase to its primary metabolite, the inactive,water-soluble carboxylic acid. Approximately 40% to 70%of articaine administered epidurally is metabolized to thecarboxylic acid, articainic acid. Approximately 4% to 15%of the articainic acid undergoes glucuronide conjugationand only 3% of the dose is recovered unchanged in theurine. The rapid plasma metabolism and reported inactivityof the carboxylic acid metabolite make articaine a potentiallysafer anesthetic agent when multiple or large dosesare necessary.

Cinchocaine Upstream-Materialien And Downstream Produkte

Cinchocain Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

85-79-0, Cinchocaine Verwandte Suche:

Send Inquriy