3-(10,10-Dimethyl-9(10H)-anthrace-nyliden)-N,N-dimethyl-1-propan-amin-hydrochlorid

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

  H335：Kann die Atemwege reizen.

• Sicherheit

  P261：Einatmen von Staub vermeiden.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

Melitracen hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

• Chemische Eigenschaften

  Crystalline Solid

• Originator

  Trausabun,Lusofarma,W. Germany,1965

• Verwenden

  Antidepressant

• Definition

  ChEBI: Melitracen hydrochloride is a member of anthracenes.

• Manufacturing Process

  24 g of 2-o-benzoylphenylpropanol-2 (MP 116°C) were dissolved in 250 ml of anhydrous ether and the resulting solution was added dropwise while stirring to a suspension of 0.22 mol of dimethylaminopropylmagnesium chloride in 100 ml of ether. The reaction mixture was refluxed for one hour on a steam bath, and water and dilute hydrochloric acid were added until the reaction was pH 4-5. The aqueous phase was separated and 60 ml of concentrated aqueous ammonia were added. The mixture was extracted with ether, and the ether phase was separated, dried and evaporated in a steam bath. The residue was dissolved in hot petroleum ether and the solution left standing to cool for some time, whereupon 4-dimethylamino-1-phenyl-1-[2-(2-hydroxy-2- propyl)phenyl]-butanol-1 crystallized out as white crystals which were sucked off. After drying they melted at 88°C to 90°C.
  10 g of this compound were cautiously dissolved in 50 ml of concentrated sulfuric acid under cooling and the mixture was kept at room temperature for 24 hours, whereupon the reaction mixture was poured into 200 g of finely crushed ice, and concentrated aqueous ammonia was added to about pH 9, whereupon the oil which separated out was extracted with ether. The ether phase was separated, dried and the ether evaporated on a steam bath. The residue was dissolved in 20 ml of acetone and the solution neutralized with a solution of dry hydrogen chloride in ether. The white crystals of 9-γdimethylaminopropylidene-10,10-dimethyl-9,10-dihydroanthracene hydrochloride which separated out was filtered off and dried. Yield 9 g. MP 245°C to 247°C.

• Therapeutic Function

  Antidepressant

Melitracen hydrochloride Upstream-Materialien And Downstream Produkte

3-(10,10-Dimethyl-9(10H)-anthrace-nyliden)-N,N-dimethyl-1-propan-amin-hydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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10563-70-9, Melitracen hydrochloride Verwandte Suche: