Isopropylamin

Bezeichnung:Isopropylamin

CAS-Nr75-31-0

Englisch Name:Isopropylamine

CBNumberCB8854223

SummenformelC3H9N

Molgewicht59.11

MOL-Datei75-31-0.mol

Synonyma

Isopropylamin

2-Propanamin

2-Aminopropan

Isopropylamin physikalisch-chemischer Eigenschaften

Schmelzpunkt	-101 °C
Siedepunkt	32-35 °C 33-34 °C (lit.)
Dichte	0.688 g/mL at 20 °C (lit.)
Dampfdichte	2.04 (vs air)
Dampfdruck	9.2 psi ( 20 °C)
FEMA	4238 \| ISOPROPYLAMINE
Brechungsindex	n20/D 1.374(lit.)
Flammpunkt	−26 °F
storage temp.	2-8°C
Löslichkeit	1000g/l
Aggregatzustand	Crystalline Powder, Needles or Crystals
pka	10.63(at 25℃)
Farbe	APHA: ≤50
Geruch (Odor)	Strong ammoniacal; pungent, irritating, typical amine.
PH	13 (700g/l, H2O, 20℃)
Explosionsgrenze	2-10.4%(V)
Odor Threshold	0.025ppm
Geruchsart	fishy
Wasserlöslichkeit	soluble
Sensitive	Air Sensitive
JECFA Number	1581
Merck	14,5209
BRN	605259
Expositionsgrenzwerte	TLV-TWA 5 ppm (～12 mg/m³) (ACGIH, MSHA, and OSHA); TLV-STEL 10 ppm(～24 mg/m³) (ACGIH); IDLH 4000 ppm (NIOSH).
Dielectric constant	5.5（20℃）
Stabilität	Stable. Extremely flammable - note low boiling point and low flash point. Readily forms explosive mixtures with air. Incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides, perchloryl fluoride.
LogP	0.21
CAS Datenbank	75-31-0(CAS DataBase Reference)
NIST chemische Informationen	2-Propanamine(75-31-0)
EPA chemische Informationen	Isopropylamine (75-31-0)

Sicherheit

Kennzeichnung gefährlicher	F+,Xi,T
R-Sätze:	12-36/37/38-37-35-25-20/21
S-Sätze:	16-26-29-45-36/37/39
RIDADR	UN 1221 3/PG 1
WGK Germany	1
RTECS-Nr.	NT8400000
F	34
Selbstentzündungstemperatur	755 °F
TSCA	Yes
HS Code	2921 19 99
HazardClass	3
PackingGroup	I
Giftige Stoffe Daten	75-31-0(Hazardous Substances Data)
Toxizität	LD50 orally in rats: 820 mg/kg (Smyth)
IDLA	750 ppm

Gefahreninformationscode (GHS)

Isopropylamine Chemische Eigenschaften,Einsatz,Produktion Methoden

ERSCHEINUNGSBILD
HYGROSKOPISCHE FARBLOSE FLüSSIGKEIT MIT GERUCH NACH AMMONIAK.
PHYSIKALISCHE GEFAHREN
Die Dämpfe sind schwerer als Luft und können sich am Boden ausbreiten. Fernzündung möglich.
CHEMISCHE GEFAHREN
Zersetzung beim Erhitzen, unter Bildung giftiger Rauche mit Stickstoffoxiden und Cyanwasserstoff. Reagiert mit starken Oxidationsmitteln; Säuren, Säureanhydriden und Säurechloriden. Reagiert sehr heftig mit Nitroparaffinen, halogenierten Kohlenwasserstoffen, Oxidationsmitteln und vielen anderen Substanzen. Greift Kupfer und seine Verbindungen, Blei, Zink und Zinn an.
ARBEITSPLATZGRENZWERTE
TLV: 5 ppm (als TWA); 10 ppm (als STEL); (ACGIH 2005).
MAK: 5 ppm 12 mg/m?Spitzenbegrenzung: überschreitungsfaktor I(2); Schwangerschaft: Gruppe C; (DFG 2006).
AUFNAHMEWEGE
Aufnahme in den Körper durch Inhalation, über die Haut und durch Verschlucken.
INHALATIONSGEFAHREN
Beim Verdampfen bei 20°C kann sehr schnell eine gesundheitsschädliche Kontamination der Luft eintreten.
WIRKUNGEN BEI KURZZEITEXPOSITION
WIRKUNGEN BEI KURZZEITEXPOSITION:
Die Substanz verätzt die Augen, die Haut und die Atemwege. ätzend beim Verschlucken. Inhalation des Dampfes kann zu Lungenödem führen (s.Anm.). Verschlucken kann zur Aufnahme in der Lunge führen; Gefahr der Aspirationspneumonie. Exposition kann zum Tod führen.
WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION
Wiederholter oder andauernder Hautkontakt kann Dermatitis hervorrufen.
LECKAGE
Gefahrenbereich verlassen! Fachmann zu Rate ziehen! Ausgelaufene Flüssigkeit möglichst in abdichtbaren Behältern sammeln. Reste mit Sand oder inertem Absorptionsmittel aufnehmen und an einen sicheren Ort bringen. NICHT in die Kanalisation spülen. NICHT in die Umwelt gelangen lassen. Persönliche Schutzausrüstung: Vollschutzanzug mit umgebungsluftunabhängigem Atemschutzgerät.
R-Sätze Betriebsanweisung:
R12:Hochentzündlich.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S16:Von Zündquellen fernhalten - Nicht rauchen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S29:Nicht in die Kanalisation gelangen lassen.
Beschreibung
Isopropylamine (propan-2-amine, IUPAC) is a colorless, volatile liquid. It is highly flammable, with a flammable range of 2%–10.4% in air. Boiling point is 93°F (33°C), flash point is ?15°F (?26°C), and ignition temperature is 756°F (402°C).
It is miscible with water, with a specific gravity of 0.69, which is lighter than water. Vapor density is 2.04, which is heavier than air. In addition to flammability, isopropylamine is a strong irritant to tissue and has a TLV of 5 ppm in air. The four-digit UN identification number is 1221. The NFPA 704 designation for isopropylamine is health 3, flammability 4, and reactivity 0. Primary uses for isopropylamine are pharmaceuticals, dyes, insecticides, and as a dehairing agent.
Chemische Eigenschaften
Isopropylamine is a colorless, flammable liquid. Isopropylamine is miscible with water, alcohol, and ether.The odor threshold reportedly ranges from 0.21 to 0.70 ppm; the pungent, ammoniacal odor becomes irritating at 24mg/m3 (110).
Physikalische Eigenschaften
Colorless liquid with a penetrating, ammonia-like odor. Experimentally determined detection and recognition odor threshold concentrations were 500 μg/m³ (210 ppb_v) and 1.7 mg/m³ (700 ppb_v), respectively (Hellman and Small, 1974). An odor threshold concentration of 25 ppb_v was reported by Nagata and Takeuchi (1990).
Occurrence
Not reported found in natu
Verwenden
Isopropylamine is used as a dehairing agentand as an intermediate in the preparation ofmany organics.
Verwenden
Solvent, intermediate in synthesis of rubber accelerators, pharmaceuticals, dyes, insecticides, bactericides, textile specialties, and surface-active agents, dehairing agent, solubilizer for 2,4-D acid.
Verwenden
Isopropylamine is an organic compound is a widely used for the synthesis of pharmaceutical and agricultural goods such as glyphosphate herbicides and as an additive for petroleum industry. such as bentazon (BASF), Roundup (Monsanto), imazapyr (ACC) and the triazines ametryne (Novartis), atrazine (Novartis), desmetryn (Novartis), prometryn (Novartis), pramitol (Novartis), dipropetryn (Novartis), and propazine. Other applications encompass the nematicide fenamiphos (Bayer), the fungicide iprodione (Rho?ne-Poulenc), insecticides, pharmaceuticals, and surfactants.
Vorbereitung Methode
Isopropylamine can be produced from the corresponding alcohol by reacting with ammonia in the presence of a dehydrating catalyst, or from the chloride by reacting with ammonia under pressure. It is also reported that this amine can be produced from acetone and ammonia or from the acetone oxime (HSDB 1989).
Definition
ChEBI: A member of the class of alkylamines that is propane carrying an amino group at position 2.
Aroma threshold values
High strength odor; fishy type; recommend smelling in a 0.10% solution or less.
Allgemeine Beschreibung
A clear colorless liquid with an ammonia-like odor. Flash point -35°F. Boiling point 90°F. Less dense than water Vapors heavier than air. Produces toxic oxides of nitrogen during combustion. Used as a solvent and to make other chemicals.
Air & Water Reaktionen
Highly flammable. Water soluble.
Reaktivität anzeigen
Isopropylamine is a colorless, alkaline liquid, very volatile, moderately toxic, highly flammable. Dangerous fire hazard when exposed to heat, flame, sparks, or strong oxidizers. When heated to decomposition Isopropylamine emits toxic fumes of oxides of nitrogen [M. K.]. A mixture of Isopropylamine and perchloryl fluoride resulted in an uncontrolled oxidation and/or explosion, [J. Org. Chem., 1980, 45, 4036]. The reaction of 1-chloro-2,3-epoxypropane and the amine and most probably other nitrogen bases, yields a violent exotherm, [Chem. & Ind., 1971, 994].
Hazard
Highly flammable, dangerous fire risk. Strong irritant to tissue.
Health Hazard
Isopropylamine is a strong irritant to theeyes, skin, and respiratory system. A shortexposure to 10–20 ppm can cause irritationof the nose and throat in humans (Procturand Hughes 1978). Prolonged exposure tohigh concentrations may lead to pulmonaryedema. Skin contact can cause dermatitisand skin burns. Exposure to 8000 ppm for4 hours was lethal to rats.
LD50 value, oral (mice): 2200 mg/kg.
Chemische Reaktivität
Reactivity with Water No reaction; Reactivity with Common Materials: No reactions; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.
Industrielle Verwendung
Isopropylamine can be used as a dehairing agent and as a solvent. It also finds use as an intermediate in the production of insecticides, herbicides and bactericides and in the production of pharmaceuticals, dyes and rubber accelerators (HSDB 1989).
Environmental Fate
Photolytic. Low et al. (1991) reported that the photooxidation of aqueous primary amine solutions by UV light in the presence of titanium dioxide resulted in the formation of ammonium and nitrate ions.
Chemical/Physical. Releases toxic nitrogen oxides when heated to decomposition (Sax and Lewis, 1987). Forms water-soluble salts with acids.
Stoffwechsel
One would expect isopropylamine to be readily absorbed from the gut and respiratory tract. Shorter chain aliphatic amines such as isopropylamine also are efficiently absorbed through the skin (Beard and Noe 1981). When administered intravenously, isopropylamine distributed rapidly into tissue compartments with tissue/plasma ratios ranging from 1.8 in the atrium to 16.7 in the renal medulla (Privitera et al 1982). During the elimination phase, a half-life of 146 min was observed in plasma. There do not appear to be any definitive metabolic studies with this compound, however through a comparison with other substrates, one might expect oxidation to acetone and ammonia through the action of monoamine oxidase (Tipton 1980).

Isopropylamine Upstream-Materialien And Downstream Produkte

Isopropylamin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

75-31-0, Isopropylamine Verwandte Suche:

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