Amprolium

Bezeichnung:Amprolium

CAS-Nr121-25-5

Englisch Name:Amprolium

CBNumberCB6127743

SummenformelC14H19N4.Cl

Molgewicht278.79

MOL-Datei121-25-5.mol

Synonyma

Amprolium

Amprolium physikalisch-chemischer Eigenschaften

Schmelzpunkt	246-248 °C (decomp)
storage temp.	0-6°C
Löslichkeit	Soluble in DMSO
Farbe	Crystals from methanol + ethanol
Stabilität	Stable. Incompatible with strong acids, strong bases, strong oxidizing agents.
InChI	InChI=1S/C14H19N4.ClH/c1-3-6-13-16-9-12(14(15)17-13)10-18-8-5-4-7-11(18)2;/h4-5,7-9H,3,6,10H2,1-2H3,(H2,15,16,17);1H/q+1;/p-1
InChIKey	LCTXBFGHZLGBNU-UHFFFAOYSA-M
SMILES	C1(C=NC(CCC)=NC=1N)C[N+]1C=CC=CC=1C.[Cl-]
CAS Datenbank	121-25-5(CAS DataBase Reference)
EPA chemische Informationen	Amprolium (121-25-5)

Gefahreninformationscode (GHS)

Amprolium Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Amprolium is an antiprotozoal agent used for the prevention of coccidiosis in poultry.
Chemische Eigenschaften
solid
Originator
Neoprol ,SIMB
Verwenden
Coccidiostat (for poultry).
Verwenden
Amprolium is an oral coccidiostat, a thiamine analogue, which is used for the prevention and treatment of intestinal coccidiosis . It is used as a feed additive for livestock, sometimes administered in the food or drinking water of puppies and kittens, and in chickens and calves.
Definition
ChEBI: An organic chloride salt having 1-[(4-amino-2-propylpyrimidin-5-yl)methyl]-2-methylpyridin-1-ium as the counterion. Used for prevention of coccidiosis in poultry and cattle.
Manufacturing Process
1.9 grams of p-toluene sulfonyl chloride was added gradually with shaking to a cooled (0-5°C) solution of 1.67 grams of 2-n-propyl-4-amino-5-hydroxymethyl pyrimidine in 10 ml of 2-methylpyridine. The reaction mixture, after standing three hours in an ice bath, and 15 hours at room temperature, was evaporated to dryness in vacuo. The residue was dissolved in 20 ml of water, acidified with hydrochloric acid and poured over a column of Amberlite IRA- 400 ion exchange resin on the chloride cycle. The eluate was evaporated to dryness to give a residue of 1-(2-n-propyl-4-amino-5-pyrimidylmethyl)-2- methyl pyridinium chloride hydrochloride. On recrystallization from a methanol-ethanol mixture, the quaternary had melting point 246°C (dec.).
Trademarks
Amprol [Veterinary] (Merial); Amprovine [Veterinary] (Merial); Corid [Veterinary] (Merial).
Therapeutic Function
Coccidiostatic
Kontakt-Allergie
Amprolium is an antiprotozoal agent used for the prevention of coccidiosis in poultry.
Nebenwirkungen
Amprolium is considered one of the safest anticoccidial medications, and adverse reactions such as anorexia or diarrhoea may occur with high doses and prolonged use. Thiamine deficiency can cause central nervous system (CNS) symptoms, but can be reversed with the addition of thiamine to the diet. However, thiamine supplementation may affect the efficacy of the drug.
Sicherheitsprofil
When heated to decomposition emits toxic fumes of Cl-.

Amprolium Upstream-Materialien And Downstream Produkte

Amprolium Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

121-25-5, Amprolium Verwandte Suche:

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