Propan-2-ol

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Achtung

• Gefahrenhinweise

  H225：Flüssigkeit und Dampf leicht entzündbar.

  H319：Verursacht schwere Augenreizung.

  H336：Kann Schläfrigkeit und Benommenheit verursachen.

• Sicherheit

  P210：Von Hitze, heißen Oberflächen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen.

  P233：Behälter dicht verschlossen halten.

  P240：Behälter und zu befüllende Anlage erden.

  P241：Explosionsgeschützte [elektrische/Lüftungs-/ Beleuchtungs-/...] Geräte verwenden.

  P242：Nur funkenfreies Werkzeug verwenden.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

Isopropyl alcohol Chemische Eigenschaften,Einsatz,Produktion Methoden

• ERSCHEINUNGSBILD

  FARBLOSE FLüSSIGKEIT.

• PHYSIKALISCHE GEFAHREN

  Die Dämpfe mischen sich leicht mit Luft. Bildung explosionsfähiger Gemische.

• CHEMISCHE GEFAHREN

  Reagiert mit starken Oxidationsmitteln. Greift einige Kunststoffe und Gummi an.

• ARBEITSPLATZGRENZWERTE

  TLV: 200 ppm (als TWA); 400 ppm (als STEL); Krebskategorie A4 (nicht klassifizierbar als krebserzeugend für den Menschen); (ACGIH 2005).
  MAK: 200 ppm, 500 mg/m? Spitzenbegrenzung: überschreitungsfaktor II(2); Schwangerschaft: Gruppe C; (DFG 2005).
  

• AUFNAHMEWEGE

  Aufnahme in den Körper durch Inhalation der Dämpfe.

• INHALATIONSGEFAHREN

  Beim Verdampfen bei 20°C tritt langsam eine gesundheitsschädliche Kontamination der Luft ein; viel schneller jedoch beim Versprühen oder Dispergieren.

• WIRKUNGEN BEI KURZZEITEXPOSITION

  WIRKUNGEN BEI KURZZEITEXPOSITION:
  Die Substanz reizt die Augen und die Atemwege. Möglich sind Auswirkungen auf das Zentralnervensystem mit nachfolgender Depression. Exposition weit oberhalb der Arbeitsplatzgrenzwerte kann zu Bewusstlosigkeit führen.

• WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION

  Die Flüssigkeit entfettet die Haut.

• LECKAGE

  Ausgelaufene Flüssigkeit in abdichtbaren Behältern sammeln. Reste mit Sand oder inertem Absorptionsmittel aufnehmen und an einen sicheren Ort bringen. Persönliche Schutzausrüstung: Atemschutzfilter für organische Gase und Dämpfe.

• R-Sätze Betriebsanweisung:

  R11:Leichtentzündlich.
  R36:Reizt die Augen.
  R67:Dämpfe können Schläfrigkeit und Benommenheit verursachen.
  R40:Verdacht auf krebserzeugende Wirkung.
  R10:Entzündlich.
  R36/38:Reizt die Augen und die Haut.

• S-Sätze Betriebsanweisung:

  S7:Behälter dicht geschlossen halten.
  S16:Von Zündquellen fernhalten - Nicht rauchen.
  S24/25:Berührung mit den Augen und der Haut vermeiden.
  S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
  S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.

• Aussehen Eigenschaften

  C3H8O; Isopropanol, Dimethylcarbinol, 2-Hydroxypropan. Farblose Flüssigkeit mit charakteristischem Geruch.

• Gefahren für Mensch und Umwelt

  Leicht entzündlich. Nicht stark erhitzen. Nicht mit Alkali-, Erdalkalimetallen, Aluminium, Oxidationsmitteln und organischen Nitroverbindungen in Berührung bringen. Gefährliche Zersetzungsprodukte sind Peroxide.
  Reizt die Haut und Schleimhäute, vor allem als Dampf.
  LD₅₀ (oral, Ratte): 5850 mg/kg.

• Schutzmaßnahmen und Verhaltensregeln

  Schutzhandschuhe als kurzzeitiger Spritzschutz.

• Verhalten im Gefahrfall

  Mit flüssigkeitsbindendem Material, z. B. Rench Rapid aufnehmen. Der Entsorgung zuführen. Nachreinigen.
  Kohlendioxid, Wasser, Schaum, Pulver.
  Brennbar. Dämpfe schwerer als Luft. Mit Luft Bildung explosionsfähiger Gemische möglich.

• Erste Hilfe

  Nach Hautkontakt: Mit reichlich Wasser abwaschen.
  Nach Augenkontakt: Mit reichlich Wasser bei geöffnetem Lidspalt mindestens 10 Minuten ausspülen. Augenarzt hinzuziehen.
  Nach Einatmen: Frischluft.
  Nach Verschlucken: Viel Wasser trinken lassen. Erbrechen vermeiden. Sofort Arzt hinzuziehen.
  Nach Kleidungskontakt: Kontaminierte Kleidung sofort entfernen.
  Ersthelfer: siehe gesonderten Anschlag

• Sachgerechte Entsorgung

  Als halogenfreie, organische Lösemittelabfälle.

• Beschreibung

  Isopropanol is a clear, colorless alcohol that is used in the production of acetone and as a solvent in the manufacture of various industrial and commercial products. It is used by the public for a number of different purposes and is commonly known as rubbing alcohol. It is flammable and miscible with both water and many different organic solvents. Isopropanol can be prepared via three different methods: indirect hydration of propylene (the ‘strong acid’ method), direct hydration of propylene, and catalytic hydrogenation of acetone.

• Chemische Eigenschaften

  Isopropyl alcohol is a clear, colorless, mobile, volatile, flammable liquid with a characteristic, spirituous odor resembling that of a mixture of ethanol and acetone; it has a slightly bitter taste.It is miscible with water, ethyl ether, and ethyl alcohol. Isopropyl alcohol is incompatible with strong oxidizers, acetaldehyde, chlorine, ethylene oxide, acids, and isocyanates.

• Occurrence

  Reported found in apple and cognac aromas (esterified). Also found in apple, banana, grapefruit and lime juice, melon, papaya, pear, onion, peas, rutabaga, tomato, wheat bread, cheeses, milk, boiled egg, cooked beef, pork and mutton, hop oil beer, rum, cocoa, coffee, scotch whiskey, grape wines, peanut, pecan, soybean, honey, beans, plum brandy, walnut, crab, clam, prickly pear and clary sage.

• Verwenden

  Isopropyl alcohol is used in the production of acetone, isopropyl halides, glycerin, and aluminum isopropoxide; employed widely as an industrial solvent for paints, polishes, and insecticides; as an antiseptic (rubbing alcohol); and in organic synthesis for introducing the isopropyl or isopropoxy group into the molecule. Being a common laboratory solvent like methanol, the exposure risks are always high; however, its toxicity is comparatively low.

• synthetische

  Isopropyl alcohol may be prepared from propylene; by the catalytic reduction of acetone, or by fermentation of certain carbohydrates.

• Definition

  ChEBI: Isopropyl Alcohol is a secondary alcohol that is propane in which one of the hydrogens attached to the central carbon is substituted by a hydroxy group. It is an isomer of propyl alcohol with antibacterial properties.

• Application

  Isopropyl Alcohol is used in a variety of applications including as a solvent for industrial processes and coating; as a component in cleaning, car care and deicing products; as a wetting agent for printing inks and as a feedstock in the manufacture of ester and Mogas/Luboil additives.
  isopropyl alcohol is a carrier, anti-bacterial, and solvent for skin care lotions. Isopropyl alcohol is made from propylene, a petroleum derivative.
  When compared to ethanol, 50% less is required for nucleic acid precipitation, thus minimizing the total volume to be centrifuged for DNA or RNA recovery.
  Isopropyl alcohol 70% is used as an ingredient in alcohol swabs and alcohol wipes for wound cleaning, it is found in hand sanitizers, and in ear drops to prevent swimmer's ear.

• Aroma threshold values

  Detection: 40 to 601 ppm

• Allgemeine Beschreibung

  Volatile, colorless liquid with a sharp musty odor like rubbing alcohol. Flash point of 53°F. Vapors are heavier than air and mildly irritating to the eyes, nose, and throat. Density approximately 6.5 lb / gal. Used in making cosmetics, skin and hair preparations, pharmaceuticals, perfumes, lacquer formulations, dye solutions, antifreezes, soaps, window cleaners. Sold in 70% aqueous solution as rubbing alcohol.

• Air & Water Reaktionen

  Highly flammable. Water soluble.

• Reaktivität anzeigen

  Isopropyl Alcohol can react with AIR and OXYGEN over time to form unstable peroxides that can explode. Contact with 2-butanone increases the rate of peroxide formation. An explosive reaction occurs when Isopropanol is heated with (aluminum isopropoxide + crotonaldehyde). Forms explosive mixtures with trinitromethane and hydrogen peroxide. Reacts with barium perchlorate to form a highly explosive compound. Ignites on contact with dioxygenyl tetrafluoroborate, chromium trioxide and potassium-tert-butoxide. Vigorous reactions occur with (hydrogen + palladium), nitroform, oleum, COCl2, aluminum triisopropoxide and oxidizing agents. Reacts explosively with phosgene in the presence of iron salts. Incompatible with acids, acid anhydrides, halogens and aluminum . Isopropanol can react with PCl3, forming toxic HCl gas. (Logsdon, John E., Richard A. Loke., sopropyl Alcohol. Kirk-Othmer Encyclopedia of Chemical Technology. John Wiley & Sons, Inc. 1996.).

• Health Hazard

  Exposures to isopropyl alcohol cause irritation to the eyes and mucous membranes. Exposures to isopropyl alcohol for 3–5 min (400 ppm) caused mild irritation of the eyes, nose, and throat, and at 800 ppm these symptoms became severe. Ingestion or an oral dose of 25 mL in 100 mL of water produced hypotension, facial flushing, bradycardia, and dizziness. Ingestion in large quantities caused extensive hemorrhagic tracheobronchitis, bronchopneumonia, and hemorrhagic pulmonary edema. Prolonged skin contact with isopropyl alcohol caused eczema and sensitivity. Delayed dermal absorption is attributed to a number of pediatric poisonings that have occurred following repeated or prolonged sponge bathing with isopropyl alcohol to reduce fever. In several cases, symptoms included respiratory distress, stupor, and coma. Laboratory animals exposed to isopropyl alcohol develop poisoning with symptoms of hind leg paralysis, unsteadiness, lack of muscular coordination, respiratory depression, and stupor. Isopropyl alcohol is a potent CNS depressant, and in large doses causes cardiovascular depression.

• Brandgefahr

  Isopropyl Alcohol(IPA) is highly flammable in its liquid and vapor forms and flammable atmospheres can be created at temperatures as low as 540°F /120℃ . This means that any environment where IPA is being used needs to be well ventilated. It should be kept away from heat and open flame. As the vapour is heavier than air, it may spread along the ground, so care needs to be taken that the vapour is not ignited by a distant source.

• Pharmazeutische Anwendungen

  Isopropyl alcohol (propan-2-ol) is used in cosmetics and pharmaceutical formulations, primarily as a solvent in topical formulations.( It is not recommended for oral use owing to its toxicity.
  Although it is used in lotions, the marked degreasing properties of isopropyl alcohol may limit its usefulness in preparations used repeatedly. Isopropyl alcohol is also used as a solvent both for tablet film-coating and for tablet granulation, where the isopropyl alcohol is subsequently removed by evaporation. It has also been shown to significantly increase the skin permeability of nimesulide from carbomer 934.
  Isopropyl alcohol has some antimicrobial activity and a 70% v/v aqueous solution is used as a topical disinfectant. Therapeutically, isopropyl alcohol has been investigated for the treatment of postoperative nausea or vomiting.

• Sicherheit(Safety)

  Isopropyl alcohol is about twice as toxic as ethanol and should therefore not be administered orally; isopropyl alcohol also has an unpleasant taste. Symptoms of isopropyl alcohol toxicity are similar to those for ethanol except that isopropyl alcohol has no initial euphoric action, and gastritis and vomiting are more prominent; see Alcohol. Delta osmolality may be useful as rapid screen test to identify patients at risk of complications from ingestion of isopropyl alcohol. The lethal oral dose is estimated to be about 120–250mL although toxic symptoms may be produced by 20 mL.
  Adverse effects following parenteral administration of up to 20mL of isopropyl alcohol diluted with water have included only a sensation of heat and a slight lowering of blood pressure. However, isopropyl alcohol is not commonly used in parenteral products.
  Although inhalation can cause irritation and coma, the inhalation of isopropyl alcohol has been investigated in therapeutic applications.
  Isopropyl alcohol is most frequently used in topical pharmaceutical formulations where it may act as a local irritant. When applied to the eye it can cause corneal burns and eye damage.
  LD50 (dog, oral): 4.80 g/kg
  LD50 (mouse, oral): 3.6 g/kg
  LD50 (mouse, IP): 4.48 g/kg
  LD50 (mouse, IV): 1.51 g/kg
  LD50 (rabbit, oral): 6.41 g/kg
  LD50 (rabbit, skin): 12.8 g/kg
  LD50 (rat, IP): 2.74 g/kg
  LD50 (rat, IV): 1.09 g/kg
  LD50 (rat, oral): 5.05 g/kg

• Synthese

  Synthetically prepared from acetylene or propylene.

• Carcinogenicity

  CD-1 mice were exposed by inhalation to 0, 500, 2500, or 5000 ppm of isopropanol vapor for 6 h/day, 5 days/week for 18 months. An additional group of mice (all exposure levels) were assigned to a recovery group that were exposed to isopropanol for 12 months and then retained until study termination at 18 months. There was no increased frequency of neoplastic lesions in any of the isopropanol-exposed animals. Nonneoplastic lesions were limited to the testes (males) and the kidney. In the testes, enlargement of the seminal vesicles occurred in the absence of associated inflammatory or degenerative changes. The kidney effects included tubular proteinosis and/or tubular dilatation. The incidence of testicular and kidney effects was not increased in the isopropanol-exposed recovery animals.

• Environmental Fate

  The vast majority of isopropanol in the environment originates from manufacturing processes. Small amounts are produced by certain microbes, fungi, and yeast. The high volatility of isopropanol ensures that when it is released into the environment in any state, it eventually ends up in the atmosphere. There, it can be degraded by hydroxyl radicals or it can return to soil or water through precipitation. Its half-life in the environment is approximately 3.2 days and is highly biodegradable; bioaccumulation in plants and animals does not occur.

• Lager

  Isopropyl alcohol should be stored in a cool, dry, well-ventilated area in tightly sealed containers with a proper label. Outside or detached storage is preferable. Inside storage should be a flammable liquids storage room or cabinet. Workers should not store isopropyl alcohol above 37°C (100°F). Containers of isopropyl alcohol should be protected from physical damage and contact with air, and should be stored separately from strong oxidizers, acetaldehyde, chlorine, ethylene oxide, acids, and isocyanates. Isopropyl alcohol should be transported to the nearest laboratory as quickly as possible in cool containers.

• läuterung methode

  Isopropyl alcohol is prepared commercially by dissolution of propene in H2SO4, followed by hydrolysis of the sulfate ester. Major impurities are water, lower alcohols and oxidation products such as aldehydes and ketones. Purification of isopropanol follows substantially the same procedure as for n-propyl alcohol. Isopropanol forms a constant-boiling mixture, b 80.3o, with water. Most of the water can be removed from this 91% isopropanol by refluxing with CaO (200g/L) for several hours, then distilling. The distillate can be dried further with CaH2, magnesium ribbon, BaO, CaSO4, calcium, anhydrous CuSO4 or Linde type 5A molecular sieves. Distillation from sulfanilic acid removes ammonia and other basic impurities. Peroxides [indicated by liberation of iodine from weakly acid (HCl) solutions of 2% KI] can be removed by refluxing with solid stannous chloride or with NaBH4 then the alcohol is fractionally distilled. To obtain isopropanol containing only 0.002M of water, sodium (8g/L) is dissolved in material dried by distillation from CaSO4. Isopropyl benzoate (35mL) is then added and, after refluxing for 3hours, the alcohol is distilled through a 50-cm Vigreux column (p 11). [Hine & Tanabe J Am Chem Soc 80 3002 1958.] Other purification steps for isopropanol include refluxing with solid aluminium isopropoxide, refluxing with NaBH4 for 24hours, and removing acetone by treatment with, and distillation from, 2,4-dinitrophenylhydrazine. Peroxides re-form in isopropanol if it is kept for several days in contact with air. [Beilstein 1 IV 1461.]

• Toxicity evaluation

  Isopropanol is similar to other alcohols in its ability to induce central nervous system (CNS) depression by enhancing inhibitory neuronal activity and antagonizing excitatory neuronal activity. It also can cause localized irritation upon contact with skin and mucous membranes after dermal exposure and ingestion, respectively.

• Inkompatibilitäten

  Incompatible with oxidizing agents such as hydrogen peroxide and nitric acid, which cause decomposition. Isopropyl alcohol may be salted out from aqueous mixtures by the addition of sodium chloride, sodium sulfate, and other salts, or by the addition of sodium hydroxide.

• Vorsichtsmaßnahmen

  Workers should wash hands and face thoroughly after handling isopropyl alcohol. Workers should wear gloves, safety glasses and a face shield, boots, apron, and a full impermeable suit is recommended if exposure is possible to a large portion of the body.

• Regulatory Status

  Included in the FDA Inactive Ingredients Database (oral capsules, tablets, and topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

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