Amproliumhydrochlorid

Bezeichnung:Amproliumhydrochlorid

CAS-Nr137-88-2

Englisch Name:Amprolium Hydrochloride

CBNumberCB2101848

SummenformelC14H20Cl2N4

Molgewicht315.24

MOL-Datei137-88-2.mol

Synonyma

Amproliumhydrochlorid

Amproliumhydrochlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	239.0 to 243.0 °C
storage temp.	Inert atmosphere,Room Temperature
Löslichkeit	Methanol (Slightly), Water (Slightly)
Aggregatzustand	Powder
Farbe	White to Off-white
BRN	4118699
InChI	InChI=1S/C14H19N4.2ClH/c1-3-6-13-16-9-12(14(15)17-13)10-18-8-5-4-7-11(18)2;;/h4-5,7-9H,3,6,10H2,1-2H3,(H2,15,16,17);2*1H/q+1;;/p-1
InChIKey	PJBQYZZKGNOKNJ-UHFFFAOYSA-M
SMILES	C1(C=NC(CCC)=NC=1N)C[N+]1C=CC=CC=1C.Cl.[Cl-]
CAS Datenbank	137-88-2(CAS DataBase Reference)
EPA chemische Informationen	Amprolium hydrochloride (137-88-2)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	20/21/22-36/37/38
S-Sätze:	22-24/25-36-26
WGK Germany	3
RTECS-Nr.	TJ7565000
HS Code	29335995

Gefahreninformationscode (GHS)

Amprolium Hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
Amprolium is a thiamine analog and antiprotozoal agent that interferes with thiamine metabolism and inhibits carbohydrate synthesis. It competitively inhibits thiamine uptake by E. tenella schizonts and by chick host intestinal cells (K_is = 7.6 and 326 μM, respectively). It also inhibits hexose formation and pentose utilization ex vivo in isolated lysed rat erythrocytes and in liver, kidney, heart, and intestinal tissue homogenates following dietary administration. Amprolium (1,000 ppm in feed) inhibits oocyst output and sporulation of Eimeria maxima, E. brunetti, and E. acervulina in infected chicks. It also decreases lesion and oocyst scores and mortality of E. tenella-infected chicks following dietary administration of a 125 ppm dose. Amprolium (100 μM) induces apoptosis in PC12 rat adrenal cells and increases the level of cleaved caspase-3. Formulations containing amprolium have been used as coccidiostats in poultry processing.
Chemische Eigenschaften
Crystalline powder
Verwenden
Coccidiostatic;Thiamine transport inhibitor
Verwenden
1-(4-Amino-2-n-propyl-5-pyrimidinylmethyl)-2-methylpyridinium Chloride is an antiparasytic drug used in the veterinary industry. In addition the compound shows anticoccidial activity.
Verwenden
Thiamine analog coccidiostat.
Definition
MeSH: Amprolium Hydrochloride is a veterinary coccidiostat that interferes with thiamine metabolism.
Kontakt-Allergie
Amprolium is an antiprotozoal agent used for the prevention of coccidiosis in poultry.
Veterinary Drugs and Treatments
Amprolium has good activity against Eimeria tenella and E. acervulina in poultry and can be used as a therapeutic agent for these organisms. It only has marginal activity or weak activity against E. maxima, E. mivati, E. necatrix, or E. brunetti. It is often used in combination with other agents (e.g., ethopabate) to improve control against those organisms.
In cattle, amprolium has approval for the treatment and prevention of E. bovis and E. zurnii in cattle and calves.
Amprolium has been used in dogs, swine, sheep, and goats for the control of coccidiosis, although there are no approved products in the USA for these species.

Amproliumhydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

137-88-2, Amprolium Hydrochloride Verwandte Suche:

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