Propyl-3,4,5-trihydroxybenzoat Produkt Beschreibung

Propyl gallate Struktur
  • CAS-Nr.121-79-9
  • Bezeichnung:Propyl-3,4,5-trihydroxybenzoat
  • Englisch Name:Propyl gallate
  • Synonyma:Propyl-3,4,5-trihydroxybenzoat
    nipa49;Nipa 49;tenoxpg;Tenox PG;FEMA 2947;FEMA 2974;NCI-C50588;Sustane PG;PROGALLIN P;nci-c505888
  • CBNumber:CB1465703
  • Summenformel:C10H12O5
  • Molgewicht:212.2
  • MOL-Datei:121-79-9.mol
Propyl-3,4,5-trihydroxybenzoat physikalisch-chemischer Eigenschaften
  • Schmelzpunkt: :146-149 °C(lit.)
  • Siedepunkt: :312.03°C (rough estimate)
  • Dichte :1.210
  • Brechungsindex :1.5140 (estimate)
  • Flammpunkt: :187℃
  • storage temp.  : 0-6°C
  • Löslichkeit :ethanol: 50 mg/mL
  • Aggregatzustand :powder
  • pka :8.11(at 25℃)
  • Farbe :White to light beige
  • Wasserlöslichkeit :0.35 g/100 mL (25 ºC)
  • Merck  :14,7859
  • BRN  :1877976
  • CAS Datenbank :121-79-9(CAS DataBase Reference)
  • NIST chemische Informationen :Benzoic acid, 3,4,5-trihydroxy-, propyl ester(121-79-9)
  • Kennzeichnung gefährlicher :Xn
  • R-Sätze: :22-43-36/37/38
  • S-Sätze: :24-37-36-26
  • WGK Germany  :2
  • RTECS-Nr. :LW8400000
  • TSCA  :Yes
  • HS Code  :29182950
  • Giftige Stoffe Daten :121-79-9(Hazardous Substances Data)
  • Toxizität :LD50 in mice, rats, hamsters, rabbits (g/kg): 1.70-3.50, 2.1-7, 2.48, 2.75 orally; LD50 i.p. in rats: 0.38 g/kg (J. Am. Coll. Toxicol.)

Propyl gallate Chemische Eigenschaften,Einsatz,Produktion Methoden

  • R-Sätze Betriebsanweisung: R22:Gesundheitsschädlich beim Verschlucken.
    R43:Sensibilisierung durch Hautkontakt möglich.
    R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
  • S-Sätze Betriebsanweisung: S24:Berührung mit der Haut vermeiden.
    S37:Geeignete Schutzhandschuhe tragen.
    S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
    S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
  • Chemische Eigenschaften Propyl gallate is a white, odorless or almost odorless crystalline powder, with a bitter astringent taste that is not normally noticeable at the concentrations employed as an antioxidant.
  • Chemische Eigenschaften white to light beige crystalline powder
  • Chemische Eigenschaften Propyl gallate is an odorless powder having a slightly bitter taste. It functions particularly well in stabilizing animal fats and vegetable oils. With a melting point of 148°C, propyl gallate loses its effectiveness during heat processing and is therefore not suitable in frying applications that involve temperatures exceeding 190°C. Propyl gallate chelates iron ions and forms an unappealing, blue–black complex. Hence, it is always used with chelators such as citric acid to eliminate the pro-oxidative iron and copper catalysts. Good synergism is obtained with BHA and BHT; however, application with TBHQ is not permitted. For additional details, refer to Burdock (1997).
  • Verwenden Propyl Gallate is a known inhibitor of Tyrosinase, a polyphenol oxidase, which is an important enzyme in pigment biosynthesis in various organisms. It has also recently been seen to boost biodiesel li pid biosynthesis in cultures.
  • Verwenden Antioxidant for cosmetics, foods, fats, oils, ethers, emulsions, waxes, transformer oils.
  • Verwenden Propyl Gallate is an antioxidant that is the n-propylester of 3,4,5-tri- hydroxybenzoic acid. natural occurrence of propyl gallate has not been reported. it is commercially prepared by esterification of gallic acid with propyl alcohol followed by distillation to remove excess alcohol.
  • Verwenden propyl gallate is an anti-oxidant with preservative properties.
  • synthetische Produced commercially by the esterification of gallic acid with propyl alcohol followed by distillation to remove the excess alcohol.
  • Vorbereitung Methode Propyl gallate is prepared by the esterification of 3,4,5-trihydroxybenzoic acid (gallic acid) with n-propanol. Other alkyl gallates are prepared similarly using an appropriate alcohol of the desired alkyl chain length.
  • Allgemeine Beschreibung Fine white to creamy-white crystalline powder. Odorless or with a faint odor. Melting point 150°C. Insoluble in water. Slightly bitter taste.
  • Air & Water Reaktionen Insoluble in water.
  • Reaktivität anzeigen Propyl gallate can react with oxidizing agents. Incompatible with strong acids, strong bases and strong reducing agents. Darkens in the presence of iron and iron salts. Contact with metals should be avoided .
  • Hazard Use in foods restricted to 0.02% of fat con- tent.
  • Brandgefahr Propyl gallate is combustible.
  • Pharmazeutische Anwendungen Propyl gallate has become widely used as an antioxidant in cosmetics, perfumes, foods, and pharmaceuticals since its use in preventing autoxidation of oils was first described in 1943.It is primarily used, in concentrations up to 0.1% w/v, to prevent the rancidity of oils and fats;it may also be used at concentrations of 0.002% w/v to prevent peroxide formation in ether, and at 0.01% w/v to prevent the oxidation of paraldehyde. Synergistic effects with other antioxidants such as butylated hydroxyanisole and butylated hydroxytoluene have been reported. Propyl gallate is also said to possess some antimicrobial properties;
    Studies have shown that, when added to powder blends containing ketorolac, propyl gallate significantly increases the drug stability in the preparation.
    Other alkyl gallates are also used as antioxidants and have approximately equivalent antioxidant properties when used in equimolar concentration; however, solubilities vary;
    Propyl gallate has also been investigated for its therapeutic properties, mainly in animal studies.
  • Kontakt-Allergie This gallate ester (E 311) is an antioxidant frequently used in the food, cosmetic, and pharmaceutical industries to prevent the oxidation of unsaturated fatty acids into rancid-smelling compounds. It causes cosmetic dermatitis mainly from lipsticks and induced contact dermatitis in a baker, and in a female confectioner, primarily sensitized by her night cream, who fried doughnuts the margarine probably containing gallates.
  • Sicherheitsprofil Poison by ingestion and intraperitoneal routes. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. Combustible when exposed to heat or flame; can react with oxidizing materials. When heated to decomposition it emits acrid smoke and irritating fumes.
  • Toxikologie Propyl gallate (n-propyl-3,4,5-trihydroxybenzoate) is used in vegetable oils and butter. When 1.2 or 2.3% propyl gallate was added to feed for rats, loss of weight was observed. This may be due to the rats reluctance to eat food that was contaminated with the bitter taste of propyl gallate. When it was given for 10 to 16 months at the 2 to 3% level, 40% of the rats died within the first month and the remainder showed severe growth inhibition. Autopsies of rats indicated kidney damage resulting from the ingestion of propyl gallate. However, no other animal studies show serious problems and further studies indicated that propyl gallate does not cause serious chronic toxicities.
  • Sicherheit(Safety) It has been reported, following animal studies, that propyl gallate has a strong contact sensitization potential.Propyl gallate has also produced cytogenic effects in CHO-K1 cells.However, despite this, there have been few reports of adverse reactions to propyl gallate.Those that have been described include contact dermatitis, allergic contact dermatitis,and methemoglobinemia in neonates.
    The WHO has set an estimated acceptable daily intake for propyl gallate at up to 1.4 mg/kg body-weight.
    (cat, oral): 0.4 g/kg
    (mouse, oral): 1.7 g/kg
    (rat, oral): 2.1 g/kg
    (rat, IP): 0.38 g/kg
  • Enzyminhibitor This antioxidant (FW = 212.20 g/mol; CAS 121-79-9; B.P. = 150°C, Solubility: 0.35 g/100 mL water at 25°C; Decomposes in the presence of iron ions), also known as Tenox PG and 3,4,5-trihydroxybenzoic acid propyl ester, exhibits antimicrobial activity and is frequently used as an additive in food products. n-Propyl gallate also inhibits the production of ethylene. In the presence of copper ions, elevated concentrations of n- propyl gallate, induce single-strand DNA breaks. n-Propyl gallate also inhibits the superoxide-generating activity of xanthine oxidase. Note that this reagent is also reported to prevent neuronal apoptosis. In addition, this reagent has proved useful in fluorescence microscopy, reducing photobleaching. Target (s) : alkylglycerophosphoethanolamine phospho- diesterase, or lysophospholipase D; alternative oxidase (3-6); aminocyclopropane-carboxylate oxidase; 1-aminocyclopropane-1- carboxylate synthase; ascorbate oxidase; b-carotene 15,15’- monooxygenase; carotene oxidase; cyclooxygenase; CYP1A2 ; ethylene production; fatty-acid D5-desaturase; fatty-acid D6-desaturase; fatty-acid synthase; 3-galactosyl-N- acetylglucosaminide 4-a-L-fucosyltransferase; glucan 1,3-a- glucosidase, or glucosidase II, or mannosyl-oligosaccharide glucosidase II ; glucose-6-phosphatase; glycoprotein 3-a-L-fucosyltransferase ; horseradish peroxidase; hyaluronoglucosaminidase, or hyaluronidase; iodide peroxidase, or thyroid peroxidase; lipoxygenase; 15-lipoxygenase, or arachidonate 15- lipoxygenase; NADPH:cytochrome c reductase; peroxidase ; phytanoyl-CoA dioxygenase; procollagen-proline 4- dioxygenase; retinal oxidase; staphylococcal thermonuclease; tyrosine 3-monooxygenase; and xanthine oxidase.
  • Lager Propyl gallate is unstable at high temperatures and is rapidly destroyed in oils that are used for frying purposes.
    The bulk material should be stored in a well-closed, nonmetallic container, protected from light, in a cool, dry place.
  • läuterung methode Crystallise the ester from aqueous EtOH or *C6H6 (m 146-146.5o). [Beilstein 10 III 2078, 10 IV 2003.]
  • Inkompatibilitäten The alkyl gallates are incompatible with metals, e.g. sodium, potassium, and iron, forming intensely colored complexes. Complex formation may be prevented, under some circumstances, by the addition of a sequestering agent, typically citric acid. Propyl gallate may also react with oxidizing materials.
  • Regulatory Status GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (IM injections; oral, and topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Propyl gallate Upstream-Materialien And Downstream Produkte
Downstream Produkte
Propyl-3,4,5-trihydroxybenzoat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
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121-79-9, Propyl gallate Verwandte Suche:
  • Propyl gallate,3,4,5-Trihydroxybenzoic acid propyl ester, Tenox PG
  • Propyl gallate 3g [121-79-9]
  • Propyl Gallate (200 mg)G2D2031.000mg/mg(dr)
  • Propyl Gallate (200 mg)
  • n-Propyl Gallate (Ph. Eur.) pure, pharma grade
  • Propyl Gallate, USP
  • Propyl gallate, 98% 100GR
  • Propyl gallat
  • Gallic acid propyl ester , PG
  • 3,4,5-trihydroxy-benzoicacipropylester
  • Benzoicacid,3,4,5-trihydroxy-,propylester
  • NCI-C50588
  • nci-c505888
  • Nipa 49
  • nipa49
  • Nipagallin P
  • nipagallinp
  • n-Propyl ester of 3,4,5-trihydroxybenzoic acid
  • 3,4,5-Trihydroxy-Benzoic
  • PropylGallate(Antioxidant)
  • Propyl gallate SynonyMs: Propyl 3,4,5-trihydroxybenzoate
  • proply gallate
  • Propyl 3,4,5-trihydroxybenzoate 3,4,5-Trihydroxybenzoic acid propyl ester Tenox PG
  • Propyl 3,4,5-trihydroxybenzoate for synthesis
  • FEMA 2947
  • FEMA 2974
  • n-propylesterof3,4,5-trihydroxybenzoicacid
  • Propyl galiate
  • propyl3,4,5-
  • Propylester kyseliny gallove
  • propylesterkyselinygallove
  • Sustane PG
  • Tenox PG
  • tenoxpg
  • PropylGallate-(N-Propyl-3,4,5-Trihydroxybezoate)
  • Propy1 gallate
  • Propyl-3,4,5-trihydroxybenzoat
  • PROPYL GALLATE extrapure
  • Propyl gailate
  • Propyl gallate ,98%
  • Gallic acid propyl
  • Propyl 3,4,5-trihydroxybenzoate