Methyl-3,4,5-trihydroxybenzoat

Bezeichnung:Methyl-3,4,5-trihydroxybenzoat

CAS-Nr99-24-1

Englisch Name:Methyl gallate

CBNumberCB0265566

SummenformelC8H8O5

Molgewicht184.15

MOL-Datei99-24-1.mol

Synonyma

Methyl-3,4,5-trihydroxybenzoat

Methyl-3,4,5-trihydroxybenzoat physikalisch-chemischer Eigenschaften

Schmelzpunkt	201-204 °C
Siedepunkt	278.08°C (rough estimate)
Dichte	1.3840 (rough estimate)
Brechungsindex	1.5690 (estimate)
storage temp.	Inert atmosphere,Room Temperature
Löslichkeit	ethanol: 50 mg/mL, clear
pka	8.04±0.23(Predicted)
Aggregatzustand	Crystalline Powder
Farbe	White to slightly beige
Wasserlöslichkeit	SOLUBLE IN HOT WATER
Merck	14,4345
BRN	2113180
InChIKey	FBSFWRHWHYMIOG-UHFFFAOYSA-N
LogP	0.860
CAS Datenbank	99-24-1(CAS DataBase Reference)
EPA chemische Informationen	Benzoic acid, 3,4,5-trihydroxy-, methyl ester (99-24-1)

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi
R-Sätze:	22-36/37/38-43
S-Sätze:	26-36/37-24/25
WGK Germany	3
RTECS-Nr.	LW8000000
TSCA	Yes
HS Code	29182900

Gefahreninformationscode (GHS)

Methyl gallate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R43:Sensibilisierung durch Hautkontakt möglich.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
Beschreibung
Methyl gallate is a phenol that has been found in Meliaceae and has diverse biological activities. It reduces adipogenic hormonal stimulation-induced lipid accumulation in 3T3-L1 cells when used at a concentration of 50 μM. Methyl gallate is active against V. cholerae in vitro (MIC = 32 μg/ml) and reduces V. cholerae-induced intestinal fluid accumulation in suckling mice when administered at doses of 50, 100, and 200 mg/kg. It reduces tumor growth and decreases the number of intratumor CD25⁺Foxp3^high regulatory T cells (Tregs) in an EL-4 model of murine lymphoma. Methyl gallate (0.7, 7, and 70 mg/kg) reduces knee joint edema and leukocyte, neutrophil, and mononuclear cell infiltration in a mouse model of zymosan-induced arthritis.
Beschreibung
Methyl gallate is a phenolic compound found in Terminalia myriocarpa and Geranium niveum. It is also found in wine.
It is the methyl ester of gallic acid.
Chemische Eigenschaften
white to slightly beige crystalline powder
Verwenden
The gallate ester methyl gallate is used as an antioxidant. A ease was reported using a reprography paper.
Verwenden
Methyl gallate exhibits potent antitumor activities by inhibiting tumor infiltration of CD4+CD25+ regulatory T cells.
Verwenden
Methyl 3,4,5-trihydroxybenzoate exhibits potent antitumor activities by inhibiting tumor infiltration of CD4+CD25+ regulatory T cells.
Definition
ChEBI: Methyl 3,4,5-trihydroxybenzoate is a gallate ester obtained by the formal condensation of gallic acid with methanol. It exhibits anti-oxidant, anti-tumor, anti-microbial and anti-inflammatory properties. It has a role as a plant metabolite, an anti-inflammatory agent and an antioxidant.
Kontakt-Allergie
This ester of gallic acid is used as an antioxidant agent. A case was reported by using a reprography paper.
läuterung methode
Methyl gallate [99-24-1] M 184.2, m 202o. Crystallise the gallate ester from MeOH. [Beilstein 10 IV 1998.]

Methyl gallate Upstream-Materialien And Downstream Produkte

Methyl-3,4,5-trihydroxybenzoat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

99-24-1, Methyl gallate Verwandte Suche:

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