(S)-2-Carboxy-1,1-dimethylpyrrolidiniumchlorid

Bezeichnung:(S)-2-Carboxy-1,1-dimethylpyrrolidiniumchlorid

CAS-Nr4136-37-2

Englisch Name:STACHYDRINE HYDROCHLORIDE

CBNumberCB4290780

SummenformelC7H14ClNO2

Molgewicht179.64

MOL-Datei4136-37-2.mol

Synonyma

(S)-2-Carboxy-1,1-dimethylpyrrolidiniumchlorid

(S)-2-Carboxy-1,1-dimethylpyrrolidiniumchlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	225°C
storage temp.	Inert atmosphere,Store in freezer, under -20°C
Löslichkeit	Methanol (Slightly), Water (Slightly)
Aggregatzustand	Solid
Farbe	White to Off-White
Wasserlöslichkeit	Soluble in water
Merck	14,8771
Stabilität	Hygroscopic
CAS Datenbank	4136-37-2(CAS DataBase Reference)

Sicherheit

R-Sätze:	20-22
S-Sätze:	22-45-36/37/39
HS Code	29339900

Gefahreninformationscode (GHS)

STACHYDRINE HYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R20:Gesundheitsschädlich beim Einatmen.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Verwenden
Stachydrine Chloride is a constituent of the Chinese herb leonurus heterophyllus sweet. its used in clinics to support blood circulation and dispel blood stasis.
Biologische Aktivität
stachydrine is an anti-metastatic agent.stachydrine, a pyrrolidine betaine, was first isolated from seed husk and the pulp of the fruit of c. leonurus, and many other asian plants and fruits.
in vitro
the aim of a previous study was to investigate the effects of stachydrine (sta) on norepinephrine (ne) induced hypertrophy and the changes of calcium transients in neonatal rat cardiomyocytes. results showed that ne treatment could increase protein synthesis, cell surface area, the expression level of β-mhc and β/α-mhc ratio and these effects were attenuated by sta treatment. in addition, ne-induced hypertrophy was associated with accelerated decay of ca2+-transient, increased phospholamban expression, increased ca2+-transient amplitude, hyper-phosphorylation, increased intracellular camp level, as well as pka overactivation. all of these effects could be inhibited by sta treatment significantly [1].
in vivo
previous study evaluated the effect of stachydrine on the expression of caspase-9 and 12 in rats with unilateral ureteral obstruction. results showed that degree of renal interstitial fibrosis, serum creatinine, blood urea nitrogen, the renal tubular interstitial damage index, and expression of caspase-9 and 12 in the stachydrine-treatment groups were significantly decreased [2].
target
IL Receptor | T-bet | RORγt | GATA-3 | Foxp3
Einzelnachweise
[1] zhang, c. ,shan, x.-l.,liao, y.-l., et al. effects of stachydrine on norepinephrine-induced neonatal rat cardiac myocytes hypertrophy and intracellular calcium transients. bmc complement. altern. med. 14, 474 (2014).
[2] zhang c, lu y, zhou yj, tong qq, qu c, kang tj. the effect of stachydrine on the expression of caspase-12 in rats with unilateral ureteral obstruction. j urol. 2014 nov;192(5):1549-54.

STACHYDRINE HYDROCHLORIDE Upstream-Materialien And Downstream Produkte

(S)-2-Carboxy-1,1-dimethylpyrrolidiniumchlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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