Moroxydinhydrochlorid

Bezeichnung:Moroxydinhydrochlorid

Englisch Name:Moroxydine hydrochloride

CBNumberCB2308986

SummenformelC6H14ClN5O

Molgewicht207.66

Synonyma

Moroxydinhydrochlorid

Moroxydinhydrochlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	211-214 °C(lit.)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
Löslichkeit	DMSO (Very Slightly, Heated), Water (Slightly)
Aggregatzustand	Solid
Farbe	Off-White
Merck	14,6272
InChIKey	FXYZDFSNBBOHTA-UHFFFAOYSA-N

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-37/39
WGK Germany	3
RTECS-Nr.	QD9815000
HS Code	2934.99.4700

Gefahreninformationscode (GHS)

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Originator
Grippe,Nissin
Verwenden
Moroxydine hydrochloride is an antiviral used against a number of RNA and DNA viruses.
Verwenden
Moroxydine is an antiviral used against a number of RNA and DNA viruses.
Manufacturing Process
43.5 g morpholine, 41.7 ml concentrated hydrochloric acid, 40 ml of water, and 42 g dicyandiamide are refluxed for 48 hours, whereupon the reaction mixture is cooled to +5°C and filtered. The filtrate is evaporated to dryness and extracted and extracted with boiling ethanol. Yield: 50 g. The formed 4- morpholinecarboximidoylguanidine hydrochloride is purified by recrystallization from methanol. The salt may be converted into the base by adding equivalent of any basic compound (triethylamine, sodium bicarbonate and so on).
In practice it is usually used as hydrochloride.
Therapeutic Function
Antiviral
Allgemeine Beschreibung
Determination of moroxydine hydrochloride in Gan Mao Qing capsules by derivative spectrophotometric signal multiplier method has been reported. Therapeutical efficiency of moroxidine hydrochloride against herpes virus induced keratoconjunctivitis has been evaluated by immunofluorescence techniques.