2'-(2,3,4-Trihydroxybenzyl)-DL-serinohydrazidmonohydrochlorid

Bezeichnung:2'-(2,3,4-Trihydroxybenzyl)-DL-serinohydrazidmonohydrochlorid

CAS-Nr14919-77-8

Englisch Name:Benserazide hydrochloride

CBNumberCB4229025

SummenformelC10H16ClN3O5

Molgewicht293.7

MOL-Datei14919-77-8.mol

Synonyma

2'-(2,3,4-Trihydroxybenzyl)-DL-serinohydrazidmonohydrochlorid

2'-(2,3,4-Trihydroxybenzyl)-DL-serinohydrazidmonohydrochlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	146°C
storage temp.	2-8°C
Löslichkeit	H₂O: 10 mg/mL
Aggregatzustand	solid
Farbe	White to Off-White
PH	pH(10g/L, 25℃) : 4.0～5.0
Wasserlöslichkeit	Soluble in water, dimethyl sulfoxide and methanol. Insoluble in ethanol and acetone.
Sensitive	Light Sensitive
maximale Wellenlänge (λmax)	272nm(HCl aq.)(lit.)
Merck	14,1050
InChIKey	ULFCBIUXQQYDEI-UHFFFAOYSA-N
CAS Datenbank	14919-77-8(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
WGK Germany	2
RTECS-Nr.	VT9632300
HS Code	29280000

Gefahreninformationscode (GHS)

Benserazide hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Benserazide is an inhibitor of aromatic L-amino acid decarboxylase (AADC), an enzyme that has dopamine decarboxylase activity. It is also unable to cross the blood-brain barrier. As a result, benserazide blocks the conversion of L-DOPA to dopamine by AADC in the peripheral circulatory system. Benserazide is often combined with L-DOPA in patients with Parkinson’s disease.
Chemische Eigenschaften
White Crystalline Solid
Verwenden
Used as antiparkinsonian. A peripheral decarboxylase inhibitor
Verwenden
Antiparkinsonian;DOPA decarboxylase inhibitor
Verwenden
Inhibitor of L-aromatic amino acid decarboxylaseBenserazide hydrochloride is used as an antiparkinsonian. It is a peripheral decarboxylase inhibitor. It is used as an inhibitor for aromatic L-aminoacid decarboxylase. Further, it serves as an inhibitor of tyrosine hydroxylase (TH) and Tryptophan hydroxylase (TPH) inhibitor.
Definition
ChEBI: A hydrochloride that is the monohydrochloride salt of benserazide. An aromatic-L-amino-acid decarboxylase inhibitor (DOPA decarboxylase inhibitor) that does not enter the central nervous system, it is used as an adjunct to levodopa in the treatment of park nsonism. By preventing the conversion of levodopa to dopamine in the periphery, it causes an increase in the amount of levodopa reaching the central nervous system and so reduces the required dose. Benserazide hydrochloride has no antiparkinson actions whe given alone.
Allgemeine Beschreibung
Benserazide is a peripheral decarboxylase inhibitor.
Biochem/physiol Actions
Inhibitor of L-aromatic amino acid decarboxylase.

2'-(2,3,4-Trihydroxybenzyl)-DL-serinohydrazidmonohydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

14919-77-8, Benserazide hydrochloride Verwandte Suche:

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