Yohimbinhydrochlorid

Bezeichnung:Yohimbinhydrochlorid

CAS-Nr65-19-0

Englisch Name:Yohimbine hydrochloride

CBNumberCB4768636

SummenformelC21H27ClN2O3

Molgewicht390.9

MOL-Datei65-19-0.mol

Synonyma

Yohimbinhydrochlorid

Yohimbinhydrochlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	288-290 °C (dec.)(lit.)
alpha	99 º (c=1%, H2O, dry subst)
Brechungsindex	103 ° (C=1, H2O)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
Löslichkeit	H₂O: 10 mg/mL
Aggregatzustand	powder
Farbe	white to off-white
Optische Aktivität	[α]/D 100±5°, c = 1 in H2O
Sensitive	Light Sensitive
Merck	14,10102
InChIKey	PIPZGJSEDRMUAW-VJDCAHTMSA-N
SMILES	N1C2=C(C=CC=C2)C2=C1[C@@]1(C[C@]3([C@](CC[C@@H]([C@@H]3C(OC)=O)O)([H])CN1CC2)[H])[H].[H]Cl \|&1:9,11,12,15,16,r\|
LogP	2.201 (est)
CAS Datenbank	65-19-0(CAS DataBase Reference)
EPA chemische Informationen	Yohimbine hydrochloride (65-19-0)

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	23/24/25-33-23/24
S-Sätze:	22-36/37/39-45-24/25
RIDADR	UN 1544 6.1/PG 2
WGK Germany	3
RTECS-Nr.	ZG1015000
TSCA	Yes
HazardClass	6.1(a)
PackingGroup	II
HS Code	29339900

Gefahreninformationscode (GHS)

Yohimbine hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R33:Gefahr kumulativer Wirkungen.
R23/24:Giftig beim Einatmen und bei Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
white to slightly yellow powder, slightly fragrant, slightly bitter taste, easily soluble in chloroform, soluble in methanol, ethanol, slightly soluble in water.
Verwenden
Yohimbine hydrochloride is an Indole alkaloid with α2-adrenergic blocking activity. It is an alpha adrenergic blocker, mydriatic, antidepressant that used in the treatment of neurological disorders and erectile dysfunction.
Verwenden
Yohimbine hydrochloride is an α2-adrenergic receptor antagonist. It blocks the central α2-adrenegic receptors in the brain, thus preventing and reducing the effects of xylazine, an α2-adrenergic agonist. The sedative effects and respiratory depression that accompany xylazine administration are both antagonized and reversed by yohimbine. Yohimbine hydrochloride also produces an antidiuretic effect, and increases heart rate and blood pressure.
Allgemeine Beschreibung
Yohimbine hydrochloride is an indole alkaloid derived from the tree bark. It is an antagonist of α2-adrenergic receptors in the brain, reducing the effects of xylazine, which is an α2-adrenergic agonis.
Biochem/physiol Actions
Yohimbine is derived from the Coryanthe yohimbe tree cortex. It is an alkaloid. Yohimbine hydrochloride is an α2-adrenergic receptor antagonist. It blocks the central α2-adrenergic receptors in the brain, thus preventing and reducing the effects of xylazine, an α2-adrenergic agonist. The sedative effects and respiratory depression that accompany xylazine administration are both antagonized and reversed by yohimbine. Yohimbine hydrochloride also produces an antidiuretic effect, and increases heart rate and blood pressure. It is useful in treating erectile dysfunction and promotes sexual functioning.
Veterinary Drugs and Treatments
Yohimbine is indicated to reverse the effects of xylazine in dogs, but it is being used clinically in several other species as well.
Yohimbine may be efficacious in reversing some of the toxic effects associated with other agents (e.g., amitraz) and can be used prophylactically before amitraz dips.
Lager
Store at RT

Yohimbinhydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

65-19-0, Yohimbine hydrochloride Verwandte Suche:

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