Isoprenalinhydrochlorid

Bezeichnung:Isoprenalinhydrochlorid

CAS-Nr51-30-9

Englisch Name:Isoprenaline hydrochloride

CBNumberCB5276844

SummenformelC11H18ClNO3

Molgewicht247.72

MOL-Datei51-30-9.mol

Synonyma

Isoprenalinhydrochlorid

Isoprenalinhydrochlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	165-175 °C (dec.)(lit.)
Siedepunkt	192°C (rough estimate)
Dichte	1.2296 (rough estimate)
Brechungsindex	1.6000 (estimate)
storage temp.	2-8°C
Löslichkeit	Freely soluble in water, sparingly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.
Aggregatzustand	White solid
Farbe	White to Off-White
Wasserlöslichkeit	Soluble
BRN	3917363
Stabilität	Stable, but may be air and light sensitive. Incompatible with strong oxidizing agents.
InChI	InChI=1S/C11H17NO3.ClH/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8;/h3-5,7,11-15H,6H2,1-2H3;1H
InChIKey	IROWCYIEJAOFOW-UHFFFAOYSA-N
SMILES	C1(=CC=C(O)C(O)=C1)C(O)CNC(C)C.Cl
CAS Datenbank	51-30-9(CAS DataBase Reference)
EPA chemische Informationen	Isoproterenol hydrochloride (51-30-9)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
WGK Germany	2
RTECS-Nr.	DO1925000
F	3-8-10
HS Code	29225090
Toxizität	LD50 oral in rabbit: 3070mg/kg

Gefahreninformationscode (GHS)

Isoprenaline hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Isoprenaline hydrochloride is an FDA-approved injectable drug that is the hydrochloride form of isoprenaline and is used as a bronchodilator, adrenergic beta agonist, cardiotonic, and sympathomimetic. Selective beta-adrenergic agonist that increases cytoplasmic cAMP. promotes glycogenolysis and causes bronchodilation. Increases Cl- diffusion and potential difference in rabbit tracheal cells via nitric oxide production. In addition, it can be used as an inducer in an experimental rat model of induced myocardial infarction^[1].
Chemische Eigenschaften
White or almost white, crystalline powder.
Verwenden
Isoproterenol hydrochloride is used as a selective β-adrenergic agonist, increases cytosolic cAMP.
Verwenden
Isoproterenol is a non-selective beta-adrenergic agonist. Isoproterenol is used in the treatment of bradycardia; bronchodilator.
Definition
ChEBI: DL-Isoprenaline hydrochloride is a member of catechols.
Trademarks
Isuprel (Hospira); Isuprel (Sanofi Aventis); Vapo- ISO (Fisons).
Allgemeine Beschreibung
Odorless white crystalline powder. Slightly bitter taste. Aqueous solutions turn brownish-pink upon prolonged exposure to air.
Air & Water Reaktionen
May be sensitive to exposure to air and light. . Water soluble.
Reaktivität anzeigen
An acid organic salt. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible.
Health Hazard
SYMPTOMS: Symptoms of exposure to Isoprenaline hydrochloride may include tremors, nervous apprehension, palpitations of the heart, epigastric distress, cardiac arrhythmias, myocardial necrosis, cardiac arrest, tachycardia, headache, flushing of the skin, anginal pain, nausea, dizziness, weakness, and sweating.
Brandgefahr
Flash point data for Isoprenaline hydrochloride are not available. Isoprenaline hydrochloride is probably combustible.
Biologische Aktivität
Standard selective β -adrenoceptor agonist; vasorelaxant and bronchodilator. Activation of β 2 receptors activates downstream PKA and ERK, and may stimulate NO-mediated endothelium-dependent smooth muscle relaxation. Active in vivo . Also available as part of the β -Adrenoceptor Agonist Tocriset™ and Mixed Adrenergic Tocriset™ .
Biochem/physiol Actions
β-adrenoceptor agonist; increases cytosolic cAMP.
Lager
Store at RT
Einzelnachweise
[1] FANG WANG. Fucoxanthin averts isoprenaline hydrochloride-induced myocardial infarction in rats[J]. Pharmacognosy Magazine, 2020, 16 1: 214-220. DOI:10.4103/pm.pm\_357\_19.

Isoprenaline hydrochloride Upstream-Materialien And Downstream Produkte

Isoprenalinhydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

51-30-9, Isoprenaline hydrochloride Verwandte Suche:

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