(E)-1-[Bis(4-fluorphenyl)methyl]-4-cinnamylpiperazindihydrochlorid

Bezeichnung:(E)-1-[Bis(4-fluorphenyl)methyl]-4-cinnamylpiperazindihydrochlorid

CAS-Nr30484-77-6

Englisch Name:Flunarizine dihydrochloride

CBNumberCB2377940

SummenformelC26H28Cl2F2N2

Molgewicht477.42

MOL-Datei30484-77-6.mol

Synonyma

(E)-1-[Bis(4-fluorphenyl)methyl]-4-cinnamylpiperazindihydrochlorid

(E)-1-[Bis(4-fluorphenyl)methyl]-4-cinnamylpiperazindihydrochlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	188-190?C
storage temp.	2-8°C
Löslichkeit	chloroform/methanol (9:1): 50 mg/mL, clear, colorless
Farbe	White to Off-White
Merck	13,4170
BRN	4284243
CAS Datenbank	30484-77-6(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22
WGK Germany	3
RTECS-Nr.	TK9187000

Gefahreninformationscode (GHS)

Flunarizine dihydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
Chemische Eigenschaften
White Solid
Originator
Sibelium,Janssen,W. Germany,1977
Verwenden
Flunarizine dihydrochloride has been used to study the effect of flunarizine on epileptiform activity. It is also used to study its effect on high-potassium induced increase of intracellular free calcium.
Verwenden
antipsychotic, H1 antihistamine
Verwenden
Calcium channel blocker; fluorinated derivative of Cinnarizine. Vasodilator (cerebral and peripheral). This is the labeled analog.
Definition
ChEBI: Flunarizine hydrochloride is a diarylmethane.
Manufacturing Process
A mixture of 14.3 parts of di-(p-fluorophenyl)-chloromethane, 10.1 parts of 1- cinnamylpiperazine, 12.7 parts of sodium carbonate, a few crystals of potassium iodide in 200 parts of 4-methyl-2-pentanone is stirred and refluxed for 21 hours. The reaction mixture is cooled and 50 parts of water are added. The organic layer is separated, dried, filtered and evaporated.
The oily residue is dissolved in 480 parts of anhydrous diisopropyl ether. This solution is boiled with activated charcoal, filtered and to the clear filtrate is added an excess of 2-propanol, previously saturated with gaseous hydrogen chloride. The precipitated salt is filtered off and recrystallized from a mixture of 2-propanol and ethanol, yielding 1-cinnamyl-4-(di-p-fluorobenzhydryl) piperazine dihydrochloride, MP 251.5°C.
Therapeutic Function
Vasodilator
Allgemeine Beschreibung
Flunarizine has antihistamine, anticonvulsant and vestibular depressive properties. It protects endothelial cells from calcium overload-induced damage. Flunarizine is used to treat epilepsy, migraine prophylaxis, cerebral blood flow disturbances, peripheral vascular disease and vertigo.
Biologische Aktivität
Dual Na + /Ca 2+ channel blocker; a cerebral and peripheral vasodilator. Neuroprotective.
Biochem/physiol Actions
Blocks T-type Ca2+/Na+ channels; inhibits K+-induced catecholamine release from chromaffin cells

Flunarizine dihydrochloride Upstream-Materialien And Downstream Produkte

(E)-1-[Bis(4-fluorphenyl)methyl]-4-cinnamylpiperazindihydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

30484-77-6, Flunarizine dihydrochloride Verwandte Suche:

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