Piperazin Produkt Beschreibung

Piperazine Struktur
110-85-0
  • CAS-Nr.110-85-0
  • Bezeichnung:Piperazin
  • Englisch Name:Piperazine
  • Synonyma:Piperazin;1,4-Diazacyclohexan;1,4-Diethylendiamin;Diethylenimin;Hexahydropyrazin
    Upixon;Uvilon;Vermex;Antepan;Antiren;Eraverm;Pipersol;Worm-away;Anti-4.1B;Anti-DAL1
  • CBNumber:CB5852824
  • Summenformel:C4H10N2
  • Molgewicht:86.14
  • MOL-Datei:110-85-0.mol
Piperazin physikalisch-chemischer Eigenschaften
  • Schmelzpunkt: :109-112 °C (lit.)
  • Siedepunkt: :145-146 °C (lit.)
  • Dichte :1,1 g/cm3
  • Dampfdruck :0.8 mm Hg ( 20 °C)
  • Brechungsindex :1.4460
  • FEMA  :4250 | PIPERAZINE
  • Flammpunkt: :65 °C
  • storage temp.  :Store below +30°C.
  • Löslichkeit :H2O: 0.1 M at 20 °C, clear, colorless
  • Aggregatzustand :Crystalline Flakes
  • pka :9.83(at 23℃)
  • Farbe :White to slightly yellow
  • PH :11.0-12.5 (25℃, 0.1M in H2O)
  • Explosionsgrenze :14%
  • Wasserlöslichkeit :150 g/L (20 ºC)
  • Sensitive  :Air Sensitive & Hygroscopic
  • maximale Wellenlänge (λmax) :λ: 260 nm Amax: 0.035
    λ: 280 nm Amax: 0.010
  • Merck  :14,7464
  • JECFA Number :1615
  • BRN  :102555
  • Stabilität: :Stable. Hygroscopic. Light sensitive. Flammable. Incompatible with strong oxidizing agents.
  • InChIKey :GLUUGHFHXGJENI-UHFFFAOYSA-N
  • CAS Datenbank :110-85-0(CAS DataBase Reference)
  • NIST chemische Informationen :Piperazine(110-85-0)
  • EPA chemische Informationen :Piperazine (110-85-0)
Sicherheit

Piperazine Chemische Eigenschaften,Einsatz,Produktion Methoden

  • ERSCHEINUNGSBILD HYGROSKOPISCHE FARBLOSE KRISTALLEODER WEISSE FLOCKEN MIT STECHENDEM GERUCH.
  • CHEMISCHE GEFAHREN Zersetzung beim Verbrennen unter Bildung giftiger und ätzender Gase mit Stickstoffoxiden. Mittelstarke Base in wässriger Lösung. Reagiert mit Säureanhydriden, starken Säurenund starken Oxidationsmitteln unter Feuergefahr. Greift viele Metalle unter Bildung brennbarer/explosionsfähiger Gase an (z.B. Wasserstoff, ICSC-Nr. 0001).
  • ARBEITSPLATZGRENZWERTE TLV nicht festgelegt (ACGIH 2005).
    MAK: IIb (nicht festgelegt, aber Informationen vorhanden); Sensibilisierung der Atemwege und der Haut (DFG 2006).
  • AUFNAHMEWEGE Aufnahme in den Körper durch Inhalation und durch Verschlucken.
  • INHALATIONSGEFAHREN Nur ungenügende Angaben vorhanden über die Geschwindigkeit, mit der eine gesundheitsschädliche Konzentration in der Luft beim Verdampfen bei 20°C erreicht wird.
  • WIRKUNGEN BEI KURZZEITEXPOSITION WIRKUNGEN BEI KURZZEITEXPOSITION:
    Die Substanz verätzt die Augen, die Haut und die Atemwege. ätzend beim Verschlucken. Inhalation der Substanz kann zu Lungenödem führen (s.Anm.). Möglich sind Auswirkungen auf das Nervensystem mit nachfolgenden Funktionsstörungenund Bewusstlosigkeit, wenn große Mengen verschluckt werden.
  • WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION Wiederholter oder andauernder Kontakt kann zu Hautsensibilisierung führen. Wiederholte oder andauernde Inhalation kann asthmatische Beschwerden hervorrufen.
  • LECKAGE Belüftung. Verschüttetes Material in abgedeckten Behältern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern. Reste sorgfältig sammeln. An sicheren Ort bringen. NICHT in die Umwelt gelangen lassen. Persönliche Schutzausrüstung: Chemikalienschutzanzug mit umgebungsluftunabhängigem Atemschutzgerät.
  • R-Sätze Betriebsanweisung: R34:Verursacht Verätzungen.
    R42/43:Sensibilisierung durch Einatmen und Hautkontakt möglich.
    R52/53:Schädlich für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.
  • S-Sätze Betriebsanweisung: S22:Staub nicht einatmen.
    S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
    S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
    S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
    S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
  • Beschreibung Piperazine is contained in pyrazinobutazone, an equimolecular sah of piperazine and phenylbutazone. Among occupational cases, most were reported in the pharmaceutical industry or laboratory, in nurses and in veterinarians.
  • Beschreibung Piperazine (Item No. 24019) is an analytical reference standard categorized as a piperazine. This product is intended for research and forensic applications.
  • Chemische Eigenschaften Piperazine is white to cream-colored needles or powder. Characteristic ammonia-like odor. Combustible solids that do not easily ignite.
  • Chemische Eigenschaften Colorless to yellow solid; salty taste.
  • Verwenden Piperazine is used as an intermediate in themanufacture of dyes, pharmaceuticals, polymers,surfactants, and rubber accelerators.
  • Verwenden Labelled Piperazine
  • Verwenden keratolytic, antiseborheic
  • Definition ChEBI: An azacycloalkane that consists of a six-membered ring containing two nitrogen atoms at opposite positions.
  • Indications Piperazine (Vermizine) contains a heterocyclic ring that lacks a carboxyl group. It acts on the musculature of the helminths to cause reversible flaccid paralysis mediated by chloride-dependent hyperpolarization of the muscle membrane. This results in expulsion of the worm. Piperazine acts as an agonist at gated chloride channels on the parasite muscle.
    Piperazine has been used with success to treat A. lumbricoides and E. vermicularis infections, although mebendazole is now the agent of choice. Piperazine is administered orally and is readily absorbed from the intestinal tract. Most of the drug is excreted in the urine within 24 hours.
    Piperazine is an appropriate alternative to mebendazole for the treatment of ascariasis, especially in the presence of intestinal or biliary obstruction. Cure rates of more than 80% are obtained following a 2-day regimen.
    Side effects occasionally include gastrointestinal distress, urticaria, and dizziness. Neurological symptoms of ataxia, hypotonia, visual disturbances, and exacerbations of epilepsy can occur in patients with preexisting renal insufficiency. It should not be used in pregnant women because of the formation of a potentially carcinogenic and teratogenic nitrosamine metabolite. Concomitant use of piperazine and chlorpromazine or pyrantel should be avoided.
  • Trademarks Pincets (Marion Merrell Dow); Pinsirup (Marion Merrell Dow);Adelmintex;Adipalis;Adipalit;Adiver;Ancaris thenium;Ancazine;Antelmina;Antepar (b-w);Anterobius;Anthalazine;Anthelmina;Anticucs;Antivermine;Ascalix;Ascarinex;Ascarivet;Asca-trol no.3;Asepar;Askaripar;Averamexan;Bel-zine;Bioxurin;B-piperazine;Brirel;Candizine;Carudol;Ciperazin;Citrazine;Coopane;Dak;Demovermil;Diatesurico;Dicevermin;Digesan;Dilaurazine;Dispermin;Diurazina;Dowzene;Ecosan;Endorid;Entazin;Equizole-a;Escovermin;Esteropipate;Etaphylline (acetyllinate);Gentiazina;Glycopiparsol;Heksapar;Helmacid;Helmezin;Helmicide;Helmifren;Helmipar;Helmirazine (adipate);Helmirazine (citrate);Helmitin;Helmizin;Herb royal round worm treatment;Hexanthelin;Ismiverm;Janes liquid permifu;Jarabe neox;Jetsan supp. (adipate);Justalmin;Kennel-maid;Kihomato;Kontipar;Lamboxil;Lombricida tropico;Lombrifher;Lombrikal;Lombrimade;Mapiprin;Maskito;Noxiurotan;Ogen;Okuside;Optiverm;Oxiril syrup (hydrate);Oxiuran (hydrate);Oxiurasin;Oxiustip elix;Oxivermin;Oxizin;Oxucid;Oxuril;Oxypip;Oxyzin;P.c. (citrate);Padrax;Paravermin;Pariamate;Par-tega;Perin;Piavermit;Pincide;Pipan;Pip-a-ray;Pipenin;Piperacid;Piperamicin;Piperascat;Piperaskat;Piperate;Piperaverm;Piperazinal;Piperazine (adipate);Pipercrean;Piperex;Piperiod;Piperital od;Piperitol;Piper-jodina;Piperol fort;Piperone;Piperoverm;Pipertox;Piperver;Piperzinal;Pipeverm;Pipezol;Pipizan citrate;Pipracid;Piprazid;Piprazyl;Pipricide;Piptelate;Piverma;Polo-verm;Polyquil;Pripsen;Provtovermil;Razinol;Rondelim;Rondoxyl;Santoban;Siropar;Supraverm;Taenifigin;Teniver;Tivazine;Toxocan;Uricida;Uridina;Uroclear (hexamine);Urodan (phosphate);Urosolvina;Uvilon syrup (hydrate);Vanpar (hydrate);Veripar;Vermazine;Vermenter;Vermicompren;Vermidol;Vermifug;Vermilass;Vermipan;Vermiphsarmette;Vermiquimpe;Vermiquimyc;Vermisit;Vermitox;Vermofrik;Verocid;Wairmex;Wurmex;Wurmsirup siegfried Multifuge;Multifuj;Nea-vermiol;Nemafugan;Nemasin;Nematocton;Nematorazine;Neo-ifusa;.
  • Weltgesundheitsorganisation (WHO) Piperazine was first used as a treatment for gout earlier this century and its anthelminthic activity was discovered in 1949. It is also considerably cheaper than other anthelminthic drugs. In some countries where ascariasis is not endemic and where piperazine was used predominantly for the treatment of pinworm it has been withdrawn from use on the grounds that other more effective and less toxic drugs are now available (see full list). In other such countries, however, piperazine remains available in over-the-counter preparations. Clinical dosages occasionally induce transient neurological signs and concern has been expressed that in some circumstances the drug may generate small amounts of nitrosamine in the stomach. However, it is widely considered that these trace doses are unlikely to give rise to a significant carcinogenic potential. (Reference: (WHODIB) WHO Drug Information Bulletin, 1: 5, , 1983)
  • Allgemeine Beschreibung Needle-like white or colorless crystals. Shipped as a solid or suspended in a liquid medium. Very corrosive to skin, eyes and mucous membranes. Solid turns dark when exposed to light. Flash point 190°F. Used as a corrosion inhibitor and as an insecticide.
  • Air & Water Reaktionen Flammable. Absorbs water and carbon dioxide from air. Soluble in water.
  • Reaktivität anzeigen 1,4-Diazacyclohexane neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Absorbs carbon dioxide from the air, which can cause dry crystals to seem to melt. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides. 1,4-Diazacyclohexane is sensitive to light; 1,4-Diazacyclohexane absorbs water and carbon dioxide from air. 1,4-Diazacyclohexane may be corrosive to aluminum, magnesium and zinc. .
  • Health Hazard TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
  • Health Hazard Piperazine is a corrosive substance. The solidand its concentrated aqueous solutions areirritants to the skin and eyes. The irritanteffect in rabbits’ eyes was severe.
    The toxic symptoms from ingestion ofpiperazine include nausea, vomiting, excitement,change in motor activity, somnolence,and muscle contraction. The toxicity of thiscompound is low, however. The oral LD50value in rats is 1900 mg/kg. The inhalationtoxicity is very low. The inhalation LC50value in mice is 5400 mg/m3/2 h.
  • Brandgefahr Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.
  • Pharmazeutische Anwendungen A synthetic chemical, most commonly formulated as the citrate, but also available as the adipate, edetate calcium and tartrate salts.
  • Kontakt-Allergie Piperazine is contained in pyrazinobutazone, an equimolar salt of piperazine and phenylbutazone. Among occupational cases, most were reported in the pharmaceutical industry or laboratory workers, in nurses, and in veterinarians.
  • Pharmakokinetik Activity against intestinal worms requires that a substantial amount remains in the gut. However, after oral administration a variable amount is rapidly absorbed from the small intestine and subsequently excreted in the urine. Its half-life is extremely variable.
  • Clinical Use Hexahydropyrazine or diethylenediamine (Arthriticine,Dispermin) occurs as colorless, volatile crystals of the hexahydratethat are freely soluble in water. After the discoveryof the anthelmintic properties of a derivative diethylcarbamazine,the activity of piperazine itself was established.Piperazine is still used as an anthelmintic for the treatmentof pinworm (Enterobius [Oxyuris] vermicularis) and roundworm(Ascaris lumbricoides) infestations. It is available invarious salt forms, including the citrate (official in the USP)in syrup and tablet forms. Piperazine blocks the response of the ascaris muscleto acetylcholine, causing flaccid paralysis in the worm,which is dislodged from the intestinal wall and expelled inthe feces.
  • Clinical Use Ascariasis
    Pinworm
  • Nebenwirkungen Some people develop hypersensitivity, requiring cessation of treatment. Transient, mild gastrointestinal or neurological symptoms may occur.
  • Sicherheitsprofil Moderately toxic by ingestion, skin contact, intravenous, and subcutaneous routes. Mildly toxic by inhalation. A skin and severe eye irritant. Excessive absorption can cause urticaria, vomiting, diarrhea, blurred vision, and weakness. Combustible when exposed to heat or flame; can react vigorously with oxidizing materials. Explodes on contact with dicyanofurazan. To fight fire, use alcohol foam, mist, dry chemical, water spray. When heated to decomposition it emits highly toxic fumes of NOx.
  • Chemical Synthesis Piperazine (38.1.12) is a bulk product in organic synthesis. It is made from ethanolamine by heating it in ammonia at a temperature of 150–220°C and a pressure of 100–250atm. It is used as a drug in the form of a salt, and as a rule, in the form of adipinate.

  • mögliche Exposition (Piperazine): Primary irritant (w/o allergic reaction),
  • Veterinary Drugs and Treatments Piperazine is used for the treatment of ascarids in dogs, cats, horses, swine and poultry. Piperazine is considered safe to use in animals with concurrent gastroenteritis and during pregnancy.
  • Carcinogenicity No increase in lung adenomas was produced in mice administered 0.69–18.75mg of piperazine/ kg in drinking water for 20–25 weeks and sacrificed 10–13 weeks later. Mice fed the equivalent of 938 mg/kg in the diet for 28 weeks and sacrificed at 40 weeks failed to show any significant increase in the incidence of lung adenomas. An increase in lung adenomas was produced in this bioassay by administration of piperazine together with sodium nitrate, suggesting the formation of the active nitroso derivative. Sodium ascorbate inhibited tumor formation, in theory, by preventing piperazine nitrosation (304). Coadministration of 250 ppm piperazine and 500 ppm sodium nitrate in drinking water did not produce tumors in rats. None of these studies were conducted using currently accepted methods for evaluating carcinogenic potential but piperazine alone, in these assays, was noncarcinogenic.
  • Environmental Fate This molecule has a simple chemical structure and molecular weight of 86.14. It has a strong alkaline base soluble in water (1:18), glycerol, and glycols, but is only sparingly soluble in alcohol and insoluble in ether. Piperazine is not expected to hydrolyze in water. The photodegradation half-life is approximately 0.8 h. The piperazine molecule is easily denaturalized by diverse environmental factors and has a low potential for bioaccumulation or biomagnification. To improve its stability, it is usually formulated as different salts such as adipate, citrate, phosphate, hexahydrate, and sulfate. Most piperazine salts are white crystalline powders that are readily soluble in water.Exceptions are adipates, which dissolve to only a maximum concentration of 5% in water, and phosphate, which is insoluble.
  • Versand/Shipping UN2579 Piperazine, Hazard class: 8; Labels: 8-Corrosive material.
  • läuterung methode Piperazine crystallises from EtOH or anhydrous *benzene and is dried at 0.01mm. It can be sublimed under vacuum and purified by zone melting. The hydrochloride has m 172-174o (from EtOH), and the dihydrochloride crystallises from aqueous EtOH and has m 318-320o (dec, sublimes at 295-315o). The picrate has m ~200o, and the picrolonate crystallises from dimethylformamide ( m 259-261o). [Beilstein 23 H 4, 23 I 4, 23 II 3, 23 III/IV 15, 23/1 V 30.]
  • Toxicity evaluation Piperazine blocks transmission by hyperpolarizing nerve membranes at the neuromuscular junction, leading to parasite immobilization by flaccid paralysis and consequent removal from predilection and death. Piperazine is a selective agonist of GABA receptors, resulting in the opening of chloride channels and hyperpolarization of the membrane of the muscle cells of nematode parasites.
  • Inkompatibilitäten Aqueous solution is a strong base. Violent reaction with strong oxidizers and dicyanofurazan. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, nitrogen compounds, carbon tetrachloride. Attacks aluminum, copper, nickel, magnesium and zinc.
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110-85-0, Piperazine Verwandte Suche:
  • PIPERAZINE
  • 1,4-DIAZACYCLOHEXANE
  • AKOS 90646
  • AKOS BBS-00004315
  • HEXAHYDRO-1,4-DIAZINE
  • HEXAHYDROPYRAZINE
  • DIETHYLENEDIAMINE
  • Anhydrous Piperazine (PIP)
  • PIPERAZINE ANHYDROUS-FLAKES
  • PIPERAZINE REAGENTPLUS(TM) 99%
  • PIPERAZINE, REAGENTPLUS, 99%
  • PiperazineHydrateBp
  • Diethylenediamine (non-medicinal)
  • Piperazidine (non-medicinal)
  • Piperazine (non-medicinal)
  • Piperazine, extra pure, 99%
  • DIETHYLDIAMINE
  • Anhydrous ether
  • Piperazine Hexahydrtae
  • PIPRAZINE ANHYDROUS pure
  • PiperazineAnhydrous, ≥ 99.7% (GC)
  • Piperazine (anhydrous) Msynthplus
  • piperazine,anhydrous
  • Pipersol
  • Pyrazine hexahydride
  • Pyrazine, hexahydro-
  • pyrazinehexahydride
  • Upixon
  • Uvilon
  • Vermex
  • Worm-A-Ton
  • Worm-away
  • Wurmirazin
  • Diethylene diamine anhydrous
  • 1,4-Diazacyclohexane, Diethylenediamine
  • Trimetazidine Ipurity G
  • Piperazine, 99%, anhydrous
  • Pooerazine
  • PIPERAZINE, 99%PIPERAZINE, 99%PIPERAZINE, 99%
  • Trimetazidine EP Impurit G
  • PIPERAZINE ANHYD
  • Trimetazidine Impurity 7(Trimetazidine EP Impurity G)
  • Piperazine,99%,extra pure
  • Piperazine ,99% [Extra dry]
  • Piperazine,1,4-Diazacyclohexane, Diethylenediamine
  • Piperzine Anhydrous
  • Piperazine (200 mg)
  • Piperazine, extra pure, 99% 100GR
  • Piperazine, extra pure, 99% 500GR
  • PIPERAZINE ANHYDROUS FOR SYNTHESIS
  • TriMetazidine EP IMpurity-G
  • TriMetazidine Hydrochloride IMpurity G
  • Anti-4.1B
  • Anti-C17orf36
  • Anti-DAL1
  • Anti-EPB41L3 antibody produced in rabbit
  • Anti-erythrocyte membrane protein band 4.1-like 3
  • Anti-KIAA0987