Tetryzolinhydrochlorid

Bezeichnung:Tetryzolinhydrochlorid

CAS-Nr522-48-5

Englisch Name:2-Tetralin-1-yl-4,5-dihydro-1H-imidazole hydrochloride

CBNumberCB1241978

SummenformelC13H17ClN2

Molgewicht236.74

MOL-Datei522-48-5.mol

Synonyma

Tetryzolinhydrochlorid

Tetryzolinhydrochlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	248-251°C
storage temp.	Inert atmosphere,Room Temperature
Löslichkeit	H2O: freely soluble
Aggregatzustand	Solid
Farbe	White to Off-White
InChIKey	BJORNXNYWNIWEY-UHFFFAOYSA-N
CAS Datenbank	522-48-5(CAS DataBase Reference)
EPA chemische Informationen	1H-Imidazole, 4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-, monohydrochloride (522-48-5)

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi
R-Sätze:	22-36/37/38
S-Sätze:	26-36
WGK Germany	3
RTECS-Nr.	NJ4550000
HS Code	2933290000

Gefahreninformationscode (GHS)

2-Tetralin-1-yl-4,5-dihydro-1H-imidazole hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
Off-White Solid
Originator
Tyzine,Pfizer,US,1954
Verwenden
An alpha agonist, causing constriction of conjunctival blood vessels. Used in over-the-counter eye drops, this compound relieves the redness left by ocular irritants.
Verwenden
adrenergic agonist, nasal decongestant
Verwenden
2-Tetralin-1-yl-4,5-dihydro-1H-imidazole hydrochloride is an alpha agonist, causing constriction of conjunctival blood vessels,it is used in over-the-counter eye drops, this compound relieves the redness left by ocular irritants.
Definition
ChEBI: Tetrahydrozoline hydrochloride is the hydrochloride salt of tetryzoline. It is used as a nasal decongestant. It has a role as a sympathomimetic agent, a vasoconstrictor agent and a nasal decongestant. It contains a tetryzoline(1+).
Manufacturing Process
A mixture of 540 grams (9.0 mols) of ethylenediamine, 270 grams (1.53 mols) of 1,2,3,4tetrahydro-α-naphthoic acid, and 360 ml (4.32 mols) of concentrated hydrochloric acid was introduced into a two-liter, three-necked flask fitted with a thermometer, stirrer, and distillation takeoff. The mixture was distilled under a pressure of about 20 mm of mercury absolute until the temperature rose to 210°C. Thereafter, heating was continued under atmospheric pressure and when the temperature reached about 260°C, an exothermic reaction was initiated. The heat was then adjusted to maintain a reaction temperature of 275° to 280°C for 45 minutes and the mixture thereafter cooled to room temperature.
900 ml of 4 N hydrochloric acid was added and the aqueous layer stirred with warming until a clear, brown solution resulted. This brown solution was made strongly alkaline with sodium hydroxide. The oil that separated solidified and was collected on a filter leaving filtrate A. The solid was dissolved in 370 ml of alcohol with warming, and the solution was treated with 130 ml of concentrated hydrochloric acid with stirring and cooling. This acidified mixture was diluted with 300 ml of ether and chilled. The solid salt was collected and dried and the filtrate concentrated to approximately 300 ml, diluted with 300 ml of ether and the salt which separated collected and dried.
Filtrate A was extracted with ether, dried, acidified with alcoholic hydrogen chloride, and the salt which separated was collected and dried. There was thus obtained, when all the salt had been combined, 250 grams (69.3% of the theoretical yield) of 2-(1,2,3,4-tetrahydro-1-naphthyl)imidazoline hydrochloride, melting at 256° to 257°C.
Trademarks
Tetryzo- line is INN and BAN; Tetryzoline Hydrochloride is JAN; Tetrahydrozoline Nitrate is JAN.
Therapeutic Function
Nasal decongestant, Pharmaceutic aid

2-Tetralin-1-yl-4,5-dihydro-1H-imidazole hydrochloride Upstream-Materialien And Downstream Produkte

Tetryzolinhydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

522-48-5, 2-Tetralin-1-yl-4,5-dihydro-1H-imidazole hydrochloride Verwandte Suche:

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