2,3-Diphenylcycloprop-2-en-1-on

Bezeichnung:2,3-Diphenylcycloprop-2-en-1-on

CAS-Nr886-38-4

Englisch Name:DIPHENYLCYCLOPROPENONE

CBNumberCB2289953

SummenformelC15H10O

Molgewicht206.24

MOL-Datei886-38-4.mol

Synonyma

2,3-Diphenylcycloprop-2-en-1-on

2,3-Diphenylcycloprop-2-en-1-on physikalisch-chemischer Eigenschaften

Schmelzpunkt	118-122 °C (lit.)
Siedepunkt	305.09°C (rough estimate)
Dichte	1.232
Brechungsindex	1.6324 (estimate)
storage temp.	Store below +30°C.
Löslichkeit	DMF:20.0(Max Conc. mg/mL);96.97(Max Conc. mM) DMSO:20.0(Max Conc. mg/mL);96.97(Max Conc. mM) DMSO:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);2.42(Max Conc. mM) Ethanol:14.0(Max Conc. mg/mL);67.88(Max Conc. mM)
Aggregatzustand	Crystalline Powder
Farbe	Slightly pinkish-orange to beige
Merck	14,3308
BRN	608049
InChIKey	HCIBTBXNLVOFER-UHFFFAOYSA-N
LogP	1.769 (est)
CAS Datenbank	886-38-4(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	38-43
S-Sätze:	36/37
WGK Germany	3
HS Code	29142990

Gefahreninformationscode (GHS)

DIPHENYLCYCLOPROPENONE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R38:Reizt die Haut.
R43:Sensibilisierung durch Hautkontakt möglich.
S-Sätze Betriebsanweisung:
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
Beschreibung
Diphencyprone (DCP) is a contact sensitizing agent. Pretreatment with DCP reduces symptom severity in a mouse model of experimental autoimmune encephalomyelitis (EAE) induced by myelin basic protein (1-10) (MBP_1-10). It enhances IL-10 production and antigen-specific IgG2a antibody responses and reduces anaphylaxis and asthma induced by ovalbumin in mice when administered during ovalbumin immunization at a concentration of 1% v/v. Topical administration of DCP increases intrafollicular CD4⁺ and CD8⁺ T cells, reduces upper dermal inflammation, and stimulates hair growth in the C3H/HeJ mouse model of alopecia areta. Formulations containing DCP have been used in the treatment of alopecia areta.
Beschreibung
Diphencyprone is a potent contact allergen responsible for occupational contact dermatitis in chemists and dermatological staff.
Chemische Eigenschaften
slightly pinkish-orange to beige crystalline
Verwenden
Diphenylcyclopropenone was used in topical immunotherapy.
Definition
ChEBI: A cyclopropenone compound having phenyl substituents at the 2- and 3-positions.
Allgemeine Beschreibung
Diphenylcyclopropenone is a potent hapten. Its vibration frequency has been evaluated.
Kontakt-Allergie
Diphencyprone is a potent contact allergen used in topical immunotherapy to treat some severe alopecia areata. It is responsible for occupational contact dermatitis in chemists and dermatology department staff
läuterung methode
Crystallise it from cyclohexane. UV (MeCN): max 226, 282, 297nm. [Beilstein 17 IV 1736.]

DIPHENYLCYCLOPROPENONE Upstream-Materialien And Downstream Produkte

2,3-Diphenylcycloprop-2-en-1-on Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

886-38-4, DIPHENYLCYCLOPROPENONE Verwandte Suche:

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