Aminoacetonitrilhydrochlorid

Bezeichnung:Aminoacetonitrilhydrochlorid

CAS-Nr6011-14-9

Englisch Name:Aminoacetonitrile hydrochloride

CBNumberCB2181554

SummenformelC2H5ClN2

Molgewicht92.53

MOL-Datei6011-14-9.mol

Synonyma

Aminoacetonitrilhydrochlorid

Aminoacetonitrilhydrochlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	172-174°C
RTECS-Nr.	MC1950000
storage temp.	Inert atmosphere,Room Temperature
Löslichkeit	Methanol (Slightly, Heated), Water
Aggregatzustand	Powder
Farbe	White to Off-White
Wasserlöslichkeit	Soluble in water 20°C, 1000g/L.
Sensitive	Hygroscopic
Merck	14,412
CAS Datenbank	6011-14-9(CAS DataBase Reference)
EPA chemische Informationen	Aminoacetonitrile hydrochloride (6011-14-9)

Sicherheit

R-Sätze:	20/21/22-36/37/38-25
S-Sätze:	22-36/37-45-26
RIDADR	3439
TSCA	Yes
HazardClass	6.1
PackingGroup	III
HS Code	29269090

Gefahreninformationscode (GHS)

Aminoacetonitrile hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
Chemische Eigenschaften
White to light brown solid
Verwenden
Used as pharmaceutical intermediates, organic synthetic raw material transportation.
Application
Aminoacetonitrile is a useful synthetic intermediate. It is a reagent used to synthesize dipeptide nitriles as reversible and potent cathepsin S inhibitors. It can also used to prepare substituted cyclic ureas as possible HIV protease inhibitors.
synthetische
Synthesis of Aminoacetonitrile Hydrochloride by Reaction of Aminoacetonitrile with Hydrogen Chloride in Methanol: mixing the aminoacetonitrile with hydrogen chloride methanol solution, reacting at 45-50°C for 1-2 hours, cooling to below 5°C, filtering, and centrifugalizing to obtain the aminoacetonitrile hydrochloride, wherein in the hydrogen chloride methanol solution, the content of hydrogen chloride is 30-50 wt%, and the water content is less than or equal to 1%.
Preparation method of aminoacetonitrile hydrochloride
Sicherheitsprofil
An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and HCl.
läuterung methode
The salt recrystallises from dilute EtOH as hygroscopic leaflets. It is best to crystallise it from absolute EtOH/Et2O (1:1) and then recrystallise it from absolute EtOH. The melting point recorded ranges from 144o to 174o. The free base has b 58o/15mm with partial decomposition. [Klages J Prakt Chem [2] 65 189 1902, Mange J Am Chem Soc 56 2197 1934, Goldberg & Kelly J Chem Soc 1371 1947, Beilstein 4 H 344, 4 I 468, 4 II 783, 4 III 1120, 4 IV 2363.]

Aminoacetonitrile hydrochloride Upstream-Materialien And Downstream Produkte

Aminoacetonitrilhydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

6011-14-9, Aminoacetonitrile hydrochloride Verwandte Suche:

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