Trimetazidindihydrochlorid

Bezeichnung:Trimetazidindihydrochlorid

CAS-Nr13171-25-0

Englisch Name:Trimetazidine dihydrochloride

CBNumberCB6176226

SummenformelC14H24Cl2N2O3

Molgewicht339.26

MOL-Datei13171-25-0.mol

Synonyma

Trimetazidindihydrochlorid

Trimetazidindihydrochlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	231-235 °C(lit.)
storage temp.	Refrigerator
Löslichkeit	Freely soluble in water, sparingly soluble in alcohol.
Aggregatzustand	Solid
Farbe	White to Off-White
Merck	14,9705
Stabilität	Hygroscopic
InChIKey	XIRALXKCBGTYSC-UHFFFAOYSA-N
CAS Datenbank	13171-25-0(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi
R-Sätze:	22-36/37/38
S-Sätze:	26-36
WGK Germany	3
RTECS-Nr.	TM2976100
HazardClass	IRRITANT
HS Code	29339900
Toxizität	LD50 in male, female mice, rats (mg/kg): 91, 107, 124, 124 i.v.; 264, 245, 327, 288 i.p.; 528, 608, 1147, 987 orally (Harpey)

Gefahreninformationscode (GHS)

Trimetazidine dihydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Trimetazidine (hydrochloride) (Item No. 18165) is an analytical reference standard that is structurally categorized as a piperazine. It decreases fatty acid β-oxidation by reversibly inhibiting mitochondrial long-chain 3-ketoacyl thiolase (IC₅₀ = 75 nM). This, in turn, stimulates glucose oxidation. In ischemic heart, trimetazidine reduces ischemia/reperfusion injury in clinical trials. Compounds that reduce mitochondrial fatty acid β-oxidation, including trimetazidine, have shown clinical efficacy against chronic stable angina in clinical trials. In part because of its ability to ameliorate testosterone cardiotoxicity, trimetazidine has been classified as a prohibited substance by the World Anti-Doping Agency. This product is intended for research and forensic applications.
Chemische Eigenschaften
Crystalline Solid
Verwenden
1-(2,3,4-Trimethoxybenzyl)piperazine dihydrochloride or trimetazidine dihydrochloride can be used as a building block to synthesize:
- Phenylpropyl trimetazidine derivatives with potent cerebral vasodilator activity.
- Benzoylguanidine-trimetazidine derivatives for myocardial ischemic-reperfusion activity studies.
Verwenden
Antianoxic
Verwenden
Coronary vasodilator. Antianginal
Definition
ChEBI: Trimetazidine hydrochloride is an aromatic amine.

Trimetazidindihydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

13171-25-0, Trimetazidine dihydrochloride Verwandte Suche:

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