Starch Chemical Properties
- Melting point:256-258°C
- Density 1.5
- storage temp. Store at 2-8°C
- solubility H2O: 20 mg/mL, colorless, clear to slightly turbid
- form Solution
- color White
- PH4-7 (100g/l, H2O, 25℃)(slurry)
- EPA Substance Registry SystemStarch (9005-25-8)
Starch Usage And Synthesis
- Chemical Propertieswhite fine crystalline powder
- Chemical PropertiesStarch occurs as an odorless and tasteless, fine, white to off-white powder. It consists of very small spherical or ovoid granules or grains whose size and shape are characteristic for each botanical variety.
- UsesDusting powder; pharmaceutic aid.
- Usescorn starch is used as a thickener in cosmetics and in face powders. Corn starch absorbs water and is soothing to the skin. It can cause allergic reactions such as inflamed eyes, stuffy nose, and perennial hay fever. A natural material obtained from corn kernels.
- UsesStarch is a carbohydrate consisting of glucose units containing amy- lose and amylopectin which contribute to varying starch properties. starch is insoluble in cold water, but upon heating the starch gran- ules swell and burst forming starch paste. starch sources include arrowroot, corn, potato, rice, sage, tapioca, waxy corn, and wheat. starches are modified by treatment to alter their functional proper- ties. terminology designating these starches includes acid-modified cornstarch, food starch modified, modified food starch, oxidized cornstarch, pregelatinized starch, thin-boiling starch, and wheat starch, gelatinized. see specific starch.
- Production MethodsStarch is extracted from plant sources with specific processes according to the botanical origin. Typical production steps are steeping (corn), wet milling (corn, potato), dry milling (wheat), or sieving and physical separation with hydrocyclones. The last production step is usually a centrifugal separation from the starch slurry followed by drying with hot air. The starch separation process may use sulfur dioxide or peroxides as a processing aid, improving the separation process and the microbial quality of the final product.
- DefinitionA polysaccharide that occurs exclusively
in plants. Starches are extracted
commercially from maize, wheat, barley,
rice, potatoes, and sorghum. The starches
are storage reservoirs for plants; they can
be broken down by enzymes to simple sugars
and then metabolized to supply energy
needs. Starch is a dietary component of animals.
Starch is not a single molecule but a mixture of amylose (water-soluble, blue color with iodine) and amylopectin (not water-soluble, violet color with iodine). The composition is amylose 10–20%, amylopectin 80–90%.
- Definitionstarch: A polysaccharide consistingof various proportions of two glucosepolymers, amylose and amylopectin.It occurs widely in plants,especially in roots, tubers, seeds, andfruits, as a carbohydrate storageproduct and energy source. Starch istherefore a major energy source foranimals. When digested it ultimatelyyields glucose. Starch granules are insolublein cold water but disrupt ifheated to form a gelatinous solution.This gives an intense blue colourwith iodine solutions and starch isused as an indicator in certain titrations.
- General DescriptionFine, white, odorless powder. Note that granules from different vegetable sources vary in shape, size, and general appearance. A mixture of the carbohydrate polymers amylose amylopectin varying according to the vegetable source. Principally used for food.
- Reactivity ProfileStarch is combustible. Presents a dust explosion hazard if dispersed as a fine dust in air in sufficient concentrations. Granules swell greatly in water and produce a colloidal suspension. Incompatible with oxidizing agents, acids, iodine, bases. Reacts with nitric acid/sulfuric acid mixtures to give nitroStarch, an explosive.
- HazardDermatitis. Questionable carcinogen.
- Agricultural UsesStarch is reserve carbohydrate usually stored in the
seeds, roots or stems of a plant. It is the second largest
source of carbohydrates, next only to cellulose. Although
starch is widespread in plants, only a few sources are
abundant enough to make the extraction commercially
feasible. The general sources are arrowroot, barley,
corn, maize, potato, rice, sago, sorghum, tapioca and
wheat. Arrowroot, barley, potato and wheat are
commercial sources of starch, available as loosely
packed granules of varying shapes and sizes.
There are two basic types of starch molecules - the
linear starch polymer and the branched starch polymer.
Starch is a polysaccharide consisting of various
proportions of the two glucose polymers, namely,
amylose and amylopectin.
Amylose consists of an unbranched chain of 200 to 500 glucose units, whereas amylopectin consists of chains of 20 glucose units joined by cross links to give a highly branched structure. Most natural starches are mixtures of amylose and amylopectin; potato and cereal starches are 20 to 30% amylose and 70 to 80% amylopectin.
Amylum is the ordinary starch found in all green plants. A molecule of starch is built out of a large number of a-glucose rings joined through oxygen atoms, thus making starch a major energy source for animals. Starch is a tasteless, odorless, colorless, white amorphous powder insoluble in water. It turns iodine solutions intensely blue, and is used as an indicator in certain titrations. An expert can tell the source of a starch
by its appearance in a grain under the microscope. Starches in the form of rice, potato, wheat and some cereal products, supply about 70% of the world's food. Soluble starch is obtained by heating ordinary starch with 10% hydrochloric acid for 24 hours and then precipitating it with alcohol.
Natural starches are used as thickeners in food.
- Pharmaceutical ApplicationsStarch is a versatile excipient used primarily in oral solid-dosage
formulations where it is utilized as a binder, diluent, and
As a diluent, starch is used for the preparation of standardized triturates of colorants, potent drugs, and herbal extracts, facilitating subsequent mixing or blending processes in manufacturing operations. Starch is also used in dry-filled capsule formulations for volume adjustment of the fill matrix, and to improve powder flow, especially when using dried starches. Starch quantities of 3–10% w/w can act as an antiadherent and lubricant in tableting and capsule filling.
In tablet formulations, freshly prepared starch paste is used at a concentration of 3–20% w/w (usually 5–10%, depending on the starch type) as a binder for wet granulation. The required binder ratio should be determined by optimization studies, using parameters such as tablet friability and hardness, disintegration time, and drug dissolution rate.
Starch is one of the most commonly used tablet disintegrants at concentrations of 3–25% w/w; a typical concentration is 15%. When using starch, a prior granulation step is required in most cases to avoid problems with insufficient flow and segregation. A starch– lactose compound has been introduced enabling the use of granular starch in direct compression, improving the tableting process and the disintegration time of the tablets. However, starch that is not pregelatinized does not compress well and tends to increase tablet friability and capping if used in high concentrations. Balancing the elastic properties of starch with adapted excipients has been shown to improve the compaction properties in tableting.
Starch, particularly the fine powders of rice and wheat starch, is also used in topical preparations for its absorbency of liquids. Starch paste is used in ointment formulations, usually in the presence of higher ratios of glycerin.
Starch has been investigated as an excipient in novel drug delivery systems for nasal, and other site-specific delivery systems. The retrogradation of starch can be used to modify the surface properties of drug particles. Starches are useful carriers for amorphous drug preparations, such as pellets with immediate or delayed drug release obtained, for example, by melt extrusion, and they can improve the bioavailability of poorly soluble drugs.
Starch, particularly rice starch, has also been used in the treatment of children’s diarrheal diseases. Specific starch varieties with a high amylose content (resistant starches) are used as insoluble fiber in clinical nutrition, and also for colon-targeting applications. Due to their very high gelatinization temperature, these starches are used in extrusion/spheronization processes. Starches with a high amylopectin content (waxy starches) are used as the starting material for the synthesis of hydroxyethyl starch, a plasma volume expander.
Native starches conforming to pharmacopeial specifications are used as the raw materials for the production of starch-based excipients and active pharmaceutical ingredients, frequently covered with their own pharmacopeial monographs.
- Safety ProfileA nuisance dust. Mildly toxic by intraperitoneal route. A skin irritant. An allergen. Flammable when exposed to flame; can react with oxidizing materials. Moderately explosive when exposed to flame.
- SafetyStarch is an edible food substance, considered a food ingredient and
not a food additive. It is regarded as an essentially nontoxic and
nonirritant material. Starch is therefore widely used as an
excipient in pharmaceutical formulations.
Both amylose and amylopectin have been evaluated as safe and without limitation for daily intake. Allergic reactions to starch are extremely rare and individuals apparently allergic to one particular starch may not experience adverse effects with a starch from a different botanical source. The wheat proteins (gluten) are problematic for conditions such as celiac disease.
Contamination of surgical wounds with the starch glove powder used by surgeons has resulted in the development of granulomatous lesions.
LD50 (mouse, IP): 6.6 g/kg
- storageDry starch is stable if protected from high humidity. Starch is
considered to be chemically and microbiologically inert under normal storage conditions. Starch solutions or pastes are physically
unstable and are readily metabolized by microorganisms; they
should therefore be freshly prepared when used for wet granulation.
Starch should be stored in an airtight container in a cool, dry place.
- IncompatibilitiesStarch is incompatible with strongly oxidizing substances. Colored inclusion compounds are formed with iodine.
- Regulatory StatusGRAS listed. Included in the FDA Inactive Ingredients Database (buccal tablets, oral capsules, powders, suspensions and tablets; topical preparations; and vaginal tablets). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Starch Preparation Products And Raw materials
- Preparation ProductsDL-TryptophanL-LysineNorfloxacinD-SorbitolMonosodium glutamateErythromycinGentamycin sulfateLevulinic acidSodium erythorbateAbamectinGibberellic acidItaconic acidL(+)-Lactic acidOxytetracyclineTobramycinDoxycycline hydrochlorideD-Isoascorbic acidMaltitolRiboflavinHigh Fructose SyrupsMosquito repellent incenseBacillus thuringiensisTacrolimusCationic starchDEXTROSESODIUM ERYTHORBATEPotassium clavulanateSineptinaSpiramycinSISOMICIN SULFATEChlortetracycline hydrochlorideNorepinephrineKojic acidEnzyme agentGlucose syrup，driedMaize yellIow(+)-GriseofulvinEmamectin benzoate
- 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE PHENYLSELENOL DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) Ethyl isocyanoacetate Cupric acetylacetonate Aluminum acetylacetonate Tosylmethyl isocyanide 2,4-PENTANEDIONE, SILVER DERIVATIVE SALCOMINE METHYL ISOCYANOACETATE TERT-BUTYL ISOCYANIDE Starch 1500 α-Amylase modified starch starch sugar,starch syrup Polydextrose Starch
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