Potassium clavulanate Chemical Properties
- Melting point:>1600C (dec)
- alpha +55～+60°
- storage temp. 2-8°C
- solubility Freely soluble in water, slightly soluble in ethanol (96 per cent), very slightly soluble in acetone.
- form neat
- CAS DataBase Reference61177-45-5(CAS DataBase Reference)
Potassium clavulanate Usage And Synthesis
- DescriptionPotassium clavulanate is a semi-synthetic beta-lactamase inhibitor isolated from Streptomyces. The compound contains a beta-lactam ring and strongly binds to beta-lactamase at their new active site, which protects other beta-lactam antibiotics such as amoxicillin from beta-lactamase catalysis.
- UsesCombination of potassium clavulanate and amoxicillin is normally used in medicine to treat numerous different infections caused by bacteria, for instance, pneumonia, sinusitis, ear infections, urinary tract infections, bronchitis, and skin infections. Potassium clavulanate can also combined with other penicillin-based antibiotics.
- CautionsBefore taking a combination of potassium clavulanate with any other penicillin-based antibiotic, one should discuss with medical providers and let them know whether they have severe kidney disease, jaundice or liver problems. In addition, it is important to inform the physician if an individual is allergic to penicillin or cephalosporin antibiotic, such as Amoxil, Levaquin, omnicef, and cefzil.
Although it is not clear with this drug may harm an unborn baby, it is important to inform the physician if one is pregnant or intending to become pregnant. In addition, studies have indicated that pass into breast milk, thus may affect a nursing infant. As such, it is important to inform the doctor if one is breast-feeding. Children should never be given potassium clavulanate without consulting a physician.
- AdministrationThe drug should be take according to the prescription given by the doctor. Potassium clavulanate is taken orally every 12 hours at the start of a meal to minimize side effects such as stomach upset.
The extended release of the potassium clavulanate tablet must never been chewed or crushed. The medicine should be swallowed as a whole while the chewable tablet must be chewed before swallowing it. Before measuring a dose, the liquid medicine must be shaken well. The medicine should be only used for the full length of prescribed time. It is important not to skip any doses as it may lead to further infection that is resistant to antibiotics.
The medicine should never be taken with or just after ingesting a high-fat meal as it will make it harder for the body to absorb the drug.
- Side EffectsPotassium clavulanate may cause diarrhea that is bloody or watery when taken in combination with amoxicillin. It may also lead to severe stomach pain, swelling of the face or tongue, loss of appetite, fever, dark color urine, weakness, or confusion. The medicine may cause jaundice or yellowing of skin as well as vaginal itching or discharge.
- Chemical PropertiesPale Yellowish Solid
- UsesClavulanic Acid is a β-lactamase inhibitor, typically added to amoxicillin to increase its effectiveness.
- UsesClavulanic acid is a β-lactam antibiotic produced by several species of Streptomyces. The free acid degrades and is isolated and maintained as either the sodium or potassium salt. Clavulanate is a weak antibiotic, but is a potent inhibitor of β-lactamases. In combination with penicillin and cephalosporins, it shows potent synergistic activity. Clavulanic acid is a suicide inhibitor, covalently binding to a serine residue in the active site of the β-lactamase.
- UsesA -Lactamase inhibitor, typically added to amoxicillin to increase its effectiveness
- DefinitionChEBI: A potassium salt having clavulanate as the counterion. It acts as a suicide inhibitor of bacterial beta-lactamase enzymes and has only weak anitbiotic activity when administered alone. However it can be used in combination with amoxicillin trihydrate (under the trade name Augmentin) for treatment of a variety of bacterial infections, where it prevents antibiotic inactivation by microbial lactamases.
Potassium clavulanate Preparation Products And Raw materials
- Potassium iodide Potassium Acetate Potassium iodate Clavulanic acid Potassium chlorate Potassium Potassium clavulanate Potassium Citrate 4-(4-CHLORO-BENZYLOXY)-PHENYLAMINE Potassium sorbate Sodium 1-heptanesulfonate Vinyl resin POTASSIUM CYANIDE Potassium nitrate Vinyl ester resin Potassium chloride N-Vinyl-2-pyrrolidone Potassium persulfate
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