A further example of nitro rather than chloro acting as a leaving group is demonstrated in
the reaction of Ph4PHF2 with 2-chloro-6-nitrobenzonitrile to give 2-fluoro-6-
chlorobenzonitrile.
colourless to light beige crystals, crystalline
2-Chloro-6-fluorobenzonitrile was used in the synthesis of:
- rac-2-chloro-6-(oxiran-2-ylmethoxy)benzonitrile
- high-molecular-weight, soluble polyarylether alternating copolymers containing pendent cyano groups
2-Chloro-6-fluorobenzonitrile is an inhibitor of cellulose synthesis.
The ITSL for chlorofluoro benzonitrile is 0.1 μg/m3 based on an annual averaging time.
