1,2-Difluorobenzene

colourless liquid

1,2-Difluorobenzene(1,2-DFB) has been used to study the mechanism of dissociation of o-, m- and p-difluorobenzene ions by threshold photoelectron photoion coincidence spectroscopy. It has been used to study the room temperature adsorption of 1,2-DFB, 1,2-dichlorobenzene and 1,2-dibromobenzene on Si(100)2x1 by X-ray photoelectron spectroscopy and temperature programmed desorption. It is used as solvent in electrochemical studies on transition metal complexes. It is also applied as a solvent useful for electrochemical studies on transition metal complexes.

1,2-Difluorobenzene is used in electrochemical analysis of transition metal complexes. 1,2-difluorobenzene is also a potent inhibitor of NMDA receptor.

ChEBI: A difluorobenzene carrying fluoro groups at positions 1 and 2.

1,2-Difluorobenzene undergoes defluorination under very mild conditions by H₂ in the presence of NaOAc over rhodium pyridylphosphine and bipyridyl complexes tethered on a silica-supported palladium catalyst.

1,2-Difluorobenzene is prepared from 2-fluoroaniline by a Balz−Schiemann reaction with HF/pyridine as the fluorinating reagent, in which the diazonium salt formed in situ undergoes photochemically induced fluorodediazoniation in continuous flow mode^[1].

[1] Simon, K., Znidar, D., Boutet, J., Guillamot, G., Lenoir, J.-Y., Dallinger, D., & Kappe, C. O. (2023). Generation of 1,2-Difluorobenzene via a Photochemical Fluorodediazoniation Step in a Continuous Flow Mode. Organic Process Research & Development, 27(2), 322–330. https://doi.org/10.1021/acs.oprd.2c00348