ChemicalBook Product Catalog Organic Chemistry Organic fluorine compound Fluorophenol series 2,3-Difluorophenol

2,3-Difluorophenol

Product Name2,3-Difluorophenol
CAS6418-38-8
MFC6H4F2O
MW130.09
EINECS264-750-2
MOL File6418-38-8.mol

Chemical Properties

Melting point	39-42 °C (lit.)
Boiling point	54 °C/25 mmHg (lit.)
Density	1.2483 (estimate)
Flash point	134 °F
storage temp.	Inert atmosphere,2-8°C
pka	7.71±0.10(Predicted)
form	powder to lump to clear liquid
color	White or Colorless to Almost white or Almost colorless
BRN	2082265
InChI	InChI=1S/C6H4F2O/c7-4-2-1-3-5(9)6(4)8/h1-3,9H
InChIKey	RPEPGIOVXBBUMJ-UHFFFAOYSA-N
SMILES	C1(O)=CC=CC(F)=C1F
CAS DataBase Reference	6418-38-8(CAS DataBase Reference)

Safety Information

Hazard Codes	F,Xn,Xi,C
Risk Statements	11-22-36/37/38-34-20/21/22
Safety Statements	26-45-36/37/39-16
RIDADR	UN 1325 4.1/PG 2
WGK Germany	3
Hazard Note	Irritant
HazardClass	4.1
PackingGroup	III
HS Code	29081000
Storage Class	3 - Flammable liquids
Hazard Classifications	Acute Tox. 4 Oral Eye Irrit. 2 Flam. Liq. 3 Skin Irrit. 2 STOT SE 3

MSDS

Provider	Language
ACROS	English
SigmaAldrich	English
ALFA	English

Usage And Synthesis

Chemical Properties

white crystalline low melting mass

Uses

Intermediates of Liquid Crystals

Application

2,3-Difluorophenol was used in the synthesis of material-poly{methyl[3-(2-hydroxy-3,4-difluoro)phenyl]propyl siloxane} (PMDFPS) sensitive to toxic organophosphate.

Synthesis

121219-16-7

6418-38-8

Step 1: In a 500 mL round-bottomed flask, dissolve 2,3-difluorophenylboronic acid (30 g, 189.98 mmol, 1.00 eq.) in dichloromethane (250 mL). Hydrogen peroxide (30 mL) was added slowly and dropwise under stirring conditions. The reaction mixture was stirred continuously at 25°C for 2 hours. Upon completion of the reaction, the reaction mixture was washed sequentially with water and saturated saline, the organic phase was dried over anhydrous magnesium sulfate, and subsequently concentrated under reduced pressure to afford 2,3-difluorophenol 23 g (93% yield) as a brown oil.

References

[1] K.P. RAJAPPAN NAIR . Supersonic jet microwave rotational spectrum of 2,3-difluorophenol[J]. Journal of Molecular Structure, 2019, 1195: Pages 479-484. DOI:10.1016/j.molstruc.2019.06.004.
[2] WEI HE . Analytical application of poly{methyl[3-(2-hydroxy-3,4-difluoro)phenyl]propyl siloxane} as a QCM coating for DMMP detection[J]. Talanta, 2008, 76 3: Pages 698-702. DOI:10.1016/j.talanta.2008.04.022.
[3] E. MARZI M. S J Gorecka. The regioexhaustive functionalization of difluorophenols and trifluorophenols through organometallic intermediates[J]. Synthesis-Stuttgart, 2004, 441 1: 1609-1618. DOI:10.1055/S-2004-829110.

2,3-Difluorophenol

Chemical Properties

Safety Information

MSDS

Usage And Synthesis

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