Tetramethylammonium fluoride (TMAF) has been found to be an effective
fluorodenitration reagent. The good selectivity for the fluoroaromatic and not the
phenol has been attributed to the stability of ion pairing between nitrite and
tetramethylammonium ions. TMAF reacts with 2-nitrobenzonitrile to give a quantitative
conversion to 2-fluorobenzonitrile.
colorless to light yellow liquid
2-Fluorobenzonitrile was used in the synthesis of :
3-amino-1,2-benzisoxazoles
6-(acetylaminomethyl)-3-amino-1,2-benzisoxazole
5-(4′-methyl [1, 1′-biphenyl]-2-yl)-1H-tetrazole
xanthone-iminium triflates
2-Fluorobenzonitrile, also known as o-fluorobenzonitrile, is an organic aromatic fluoride. It has a wide range of applications in pharmaceuticals, pesticides, dyestuffs, etc. In the field of dyestuff, the introduction of fluorine atom makes the dyed products bright and colorful and less likely to fade, among other advantages.
2-Fluorobenzonitrile reacts with lithium N,N-dialkylaminoborohydride reagent to yield 2-(N,N-dialkylamino)benzylamines.
