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1,9-Pyrazoloanthrone

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1,9-Pyrazoloanthrone Basic information
1,9-Pyrazoloanthrone Chemical Properties
  • Melting point:281~282℃
  • Boiling point:361.16°C (rough estimate)
  • Density 1.1702 (rough estimate)
  • refractive index 1.5910 (estimate)
  • storage temp. 2-8°C
  • solubility H2O: insoluble
  • form Yellowish orange solid
  • pka11.75±0.20(Predicted)
  • color yellow
  • InChIKeyACPOUJIDANTYHO-UHFFFAOYSA-N
  • CAS DataBase Reference129-56-6(CAS DataBase Reference)
  • EPA Substance Registry SystemAnthra[1,9-cd]pyrazol-6(2H)-one (129-56-6)
Safety Information
  • Hazard Codes Xi
  • Risk Statements 36/37/38
  • Safety Statements 26-36
  • WGK Germany 3
  • RTECS CB4585000
  • TSCA Yes
  • HS Code 29339900
  • ToxicityLD50 ivn-mus: 178 mg/kg CSLNX* NX#00640
MSDS
1,9-Pyrazoloanthrone Usage And Synthesis
  • UsesA broad-spectrum serine/threonine kinase inhibitor of JNK with an IC50 range from 40 to 90 nM.
  • UsesSP 600125 is a Jun N-terminal kinase (JNK) inhibitor.
  • DefinitionChEBI: A member of the class of anthrapyrazoles that is anthra[1,9-cd]pyrazole substituted at position 6 by an oxo group. An inhibitor of c-Jun N-terminal kinase.
  • Biological ActivitySelective inhibitor of c-Jun N-terminal kinase (JNK). Competitively and reversibly inhibits JNK1, 2 and 3 (IC 50 = 40-90 nM) with negligible activity at ERK2, p38 β and a range of enzymes (IC 50 > 10 μ M). Active in vivo . Shown to have reduced selectivity over other protein kinases under certain conditions. Protects renal tubular epithelial cells against ischemia/reperfusion-induced apoptosis. Also available as part of the MAPK Inhibitor Tocriset™ .
  • Safety ProfilePoison by intravenous route.When heated to decomposition it emits toxic fumes ofNOx.
1,9-Pyrazoloanthrone Preparation Products And Raw materials
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