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Phthalylsulfathiazole

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Phthalylsulfathiazole Basic information
Phthalylsulfathiazole Chemical Properties
Safety Information
  • Safety Statements 24/25
  • RIDADR 3249
  • RTECS TH8575000
  • HazardClass 6.1(b)
  • PackingGroup III
  • HS Code 29350090
  • ToxicityLD50 i.p. in mice: 920 mg/kg (Mattis)
Phthalylsulfathiazole Usage And Synthesis
  • Chemical PropertiesWhite or yellowish-white, crystalline powder.
  • OriginatorSulfathalidine, MSD, US,1946
  • Usesantibacterial
  • Manufacturing Process5 g of phthalic anhydride was added to a boiling suspension of 10 g of sulfathiazole in 100 cc of alcohol. The mixture was then refluxed for 5 minutes after the addition was complete at which time all of the solids were in solution. The solution was then cooled and diluted with an equal volume of water, The white solid precipitate which formed was filtered and recrystallized from dilute alcohol, yielding 2-N4-phthalylsulfanilamidothiazole,which decomposes above 260°C, according to US Patent 2,324,015.
  • brand nameCanidis-anti-diarr;Carbidiar;Carbotalin;Colicitina;Coliclase;Crematalil;Diacolin;Direver;Disenterol;Ef-micin;Enterocalme;Entero-hermes;Entero-red;Enterosteril;Entero-toxan;Esteraplidin mag;Eugeniteed;Fitazil;Ftalil-tiazol;Ilentazol;Inrestibla strepto;Iodentero-neomicina;Logical;Massotalil;Neo-sulfazon;Novosulfina;Phtazol;Septiftalil;Syptan;Talisulfazol;Tamil;.
  • Therapeutic FunctionAntibacterial (intestinal)
  • World Health Organization (WHO)Phthalylsulfathiazole, a sulfonamide anti-infective agent, was introduced in 1946 for the treatment of bacterial infections. The importance of sulfonamides has subsequently decreased as a result of increasing bacterial resistance and their replacement by antibiotics which are generally more active and less toxic. Although phthalylsulfathiazole, which is poorly absorbed from the gastrointestinal tract, is no longer recommended in some countries, it continues to be used in others for the treatment of local intestinal infections, including bacterial dysentery, and for pre-operative bowel preparation.
Phthalylsulfathiazole Preparation Products And Raw materials
Phthalylsulfathiazole(85-73-4)Related Product Information
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