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Zolpidem

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Zolpidem Basic information
Zolpidem Chemical Properties
  • Melting point:189-191°C
  • Density 1.12±0.1 g/cm3(Predicted)
  • Flash point:9℃
  • storage temp. Store at RT
  • solubility 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.3 mg/mL
  • pka6.2(at 25℃)
  • form solid
  • color white
  • Water Solubility <10mg/L(room temperature)
  • CAS DataBase Reference82626-48-0(CAS DataBase Reference)
  • NIST Chemistry ReferenceZolpidem(82626-48-0)
Safety Information
  • Hazard Codes Xi
  • Risk Statements 36/37/38
  • Safety Statements 26-36
  • RIDADR UN1230 - class 3 - PG 2 - Methanol, solution
  • WGK Germany 3
  • RTECS NJ5109750
  • HS Code 2933996500
MSDS
Zolpidem Usage And Synthesis
  • DescriptionZolpidem hemitamwe is a non-benzodiazepine hypnotic with specific agonist activity at type 1 benzodiazepine receptors, and is indicated for use in insomnia and other sleep disorders. Structurally zolpidem belongs to a chemically distinct class, thus lacking the side-effects and abuse potential of classical benzodiazepines. It is currently being studied as a pre-operative sedative.
  • Chemical PropertiesOff-White Solid
  • OriginatorSynthelabo (France)
  • UsesA selective benzodiazepine receptor agonist not related chemically to benzodiazepines
  • UsesA selective non-benzodiazepine GABAA receptor agonist. Sedative, hypnotic. Controlled substance (depresssant).
  • DefinitionChEBI: An imidazo[1,2-a]pyridine compound having a 4-tolyl group at the 2-position, an N,N-dimethylcarbamoylmethyl group at the 3-position and a methyl substituent at the 6-position.
  • brand nameAmbien (Sanofi Aventis);Stilnox.
  • General DescriptionZolpidem (Ambien, an imidazopyridine) andeszopiclone (Lunesta, a cyclopyrrolone) are nonbenzodiazepinesand have been introduced as short- and moderate-acting hypnotics, respectively. Zolpidem exhibits ahigh selectivity for the α1 subunit of benzodiazepinebindingsite on GABAA receptor complex, whereas eszopicloneis a “superagonist” at BzRs with the subunitcomposition α1β2γ2 and α1β2γ3. Zolpidem has a rapidonset of action of 1.6 hours and good bioavailability(72%), mainly because it is lipophilic and has no ionizablegroups at physiological pH. Food can prolong the time topeak concentration without affecting the half-life probablyfor the same reason. It has short elimination half-life, becauseits aryl methyl groups is extensively α-hydroxylatedto inactive metabolites by CYP3A4 followed by furtheroxidation by aldehyde dehydrogenase to the ionic carboxylicacid. The metabolites are inactive, short-lived, andeliminated in the urine. Its half-life in the elderly or the patientswith liver disease is increased. Therefore, dosingshould be modified in patients with hepatic insufficiencyand the elderly. Because it has longer elimination half-lifethan zaleplon, it may be preferred for sleep maintenance.It was the most commonly prescribed drug for insomniain 2001.
Zolpidem Preparation Products And Raw materials
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