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Talc

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Talc Basic information
Talc Chemical Properties
  • Melting point:800 °C
  • Density 2.7-2.8
  • solubility Practically insoluble in water, in ethanol (96 per cent) and in dilute solutions of acids and alkali hydroxides.
  • form Powder/Solid
  • color White to pale gray
  • Water Solubility Insoluble in water, cold acids, alkalies.
  • Merck 14,9037
Safety Information
  • Hazard Codes Xn
  • Risk Statements 20-37
  • Safety Statements 36
  • WGK Germany -
  • RTECS WW2710000
  • TSCA Yes
  • HS Code 25262020
Talc Usage And Synthesis
  • Chemical PropertiesWhite to almost white micro fine powder, greasy to
  • Chemical PropertiesTalc is a very fine, white to grayish-white, odorless, impalpable, unctuous, crystalline powder. It adheres readily to the skin and is soft to the touch and free from grittiness.
  • UsesTalc is a mineral composed of hydrated magnesium silicate with the chemical formula H2Mg3(SiO3)4 or Mg3Si4O10(OH)2. Talc is used in many industries such as paper making, plastic, paint and coatings, rubber, food, electric cable, pharmaceuticals, cosmetics
  • UsesDusting powder, either alone or with starch or boric acid, for medicinal and toilet Preparations; excipient and filler for pills, tablets and for dusting tablet molds; clarifying liquids by filtration. As pigment in paints, varnishes, rubber; filler for paper, rubber, soap; in fireproof and cold-water paints for wood, metal and stone; lubricating molds and machinery; glove and shoe powder; electric and heat insulator.
  • Usestalc adds softness and sliding ability to a cosmetic formulation. It is also used as a bulking and opacifying agent, and as an absorbent in makeup preparations. Talc is an inert powder, generally made from finely ground magnesium silicate, a mineral.
  • Production MethodsTalc is a naturally occurring hydropolysilicate mineral found in many parts of the world including Australia, China, Italy, India, France, and the USA.
    The purity of talc varies depending on the country of origin. For example, Italian types are reported to contain calcium silicate as the contaminant; Indian types contain aluminum and iron oxides; French types contain aluminum oxide; and American types contain calcium carbonate (California), iron oxide (Montana), aluminum and iron oxides (North Carolina), or aluminum oxide (Alabama).
    Naturally occurring talc is mined and pulverized before being subjected to flotation processes to remove various impurities such as asbestos (tremolite); carbon; dolomite; iron oxide; and various other magnesium and carbonate minerals. Following this process, the talc is finely powdered, treated with dilute hydrochloric acid, washed with water, and then dried. The processing variables of agglomerated talc strongly influence its physical characteristics.
  • General DescriptionOdorless white to grayish-white very fine crystalline powder (unctuous). Readily adheres to the skin. Nonflammable, noncombustible, and nontoxic.
  • Air & Water ReactionsInsoluble in water.
  • Reactivity ProfileTalc has low reactivity.
  • Fire HazardLiterature sources indicate that Talc is nonflammable.
  • Pharmaceutical ApplicationsTalc was once widely used in oral solid dosage formulations as a lubricant and diluent, although today it is less commonly used. However, it is widely used as a dissolution retardant in the development of controlled-release products. Talc is also used as a lubricant in tablet formulations; in a novel powder coating for extended-release pellets; and as an adsorbant.
    In topical preparations, talc is used as a dusting powder, although it should not be used to dust surgical gloves. Talc is a natural material; it may therefore frequently contain microorganisms and should be sterilized when used as a dusting powder.
    Talc is additionally used to clarify liquids and is also used in cosmetics and food products, mainly for its lubricant properties.
  • Safety ProfileThe talc with less than 1 percent asbestos is regarded as a nuisance dust. Talc with greater percentage of asbestos may be a human carcinogen. A human skin irritant. Prolonged or repeated exposure can produce a form of pulmonary fibrosis (talc pneumoconiosis) which may be due to asbestos content. Questionable carcinogen with experimental tumorigenic data. A common air contaminant.
  • SafetyTalc is used mainly in tablet and capsule formulations. Talc is not absorbed systemically following oral ingestion and is therefore regarded as an essentially nontoxic material. However, intranasal or intravenous abuse of products containing talc can cause granulomas in body tissues, particularly the lungs. Contamination of wounds or body cavities with talc may also cause granulomas; therefore, it should not be used to dust surgical gloves. Inhalation of talc causes irritation and may cause severe respiratory distress in infants.
    Although talc has been extensively investigated for its carcinogenic potential, and it has been suggested that there is an increased risk of ovarian cancer in women using talc, the evidence is inconclusive. However, talc contaminated with asbestos has been proved to be carcinogenic in humans, and asbestos-free grades should therefore be used in pharmaceutical products.
    Also, long-term toxic effects of talc contaminated with large quantities of hexachlorophene caused serious irreversible neurotoxicity in infants accidentally exposed to the substance.
  • storageTalc is a stable material and may be sterilized by heating at 160°C for not less than 1 hour. It may also be sterilized by exposure to ethylene oxide or gamma irradiation.
    Talc should be stored in a well-closed container in a cool, dry place.
  • IncompatibilitiesIncompatible with quaternary ammonium compounds.
  • Regulatory StatusAccepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (buccal tablets; oral capsules and tablets; rectal and topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Talc Preparation Products And Raw materials
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