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Dansyl chloride

Basic information Uses Safety Related Supplier
Dansyl chloride Basic information
Dansyl chloride Chemical Properties
  • Melting point:72-74 °C(lit.)
  • Boiling point:371.3±22.0 °C(Predicted)
  • Density 1.1702 (rough estimate)
  • refractive index 1.5630 (estimate)
  • storage temp. 2-8°C
  • solubility acetone: 50 mg/mL
  • pka2.38±0.40(Predicted)
  • form powder and chunks
  • color yellow to orange
  • Water Solubility Soluble in dimethyl fluoride, acetone, chloroform, pyridine, benzene and dioxane. Insoluble in water.
  • Sensitive Moisture Sensitive
  • Merck 14,2814
  • BRN 2217205
  • InChIKeyXPDXVDYUQZHFPV-UHFFFAOYSA-N
  • CAS DataBase Reference605-65-2(CAS DataBase Reference)
  • EPA Substance Registry System1-Naphthalenesulfonyl chloride, 5-(dimethylamino)- (605-65-2)
Safety Information
  • Hazard Codes C
  • Risk Statements 34
  • Safety Statements 26-36/37/39-45-3
  • RIDADR UN 3261 8/PG 2
  • WGK Germany 3
  • RTECS QK3688000
  • 10-21
  • TSCA Yes
  • HazardClass 8
  • PackingGroup III
  • HS Code 29214980
MSDS
Dansyl chloride Usage And Synthesis
  • Uses

    Dansyl chloride or 5-Dimethylaminonaphthalene-1-sulfonyl chloride (CAS 605-65-2) is a fluorogenic reagent used for protein, N-terminal amino acid and peptide detection by reverse phase high performance liquid chromatography (HPLC). It is also used to determine the degree of labeling in chymotrypsin and ovalbumin. It acts as a precursor for the synthesis of other derivatives like dansyl amide.
    Dansyl chloride is non-fluorescent until it reacts with amines. The resulting Dansyl amides have environmentally sensitive fluorescence quantum yields and emission maxima along with large Stokes shifts. This environment-sensitive fluorescence property has made Dansyl chloride an important tool for biophysical studies.

  • Chemical Propertiesyellow to orange-yellow crystalline powder
  • UsesReagent for fluorescent labelling of amines, amino acids and proteins.
  • UsesA fluorogenic reagent for N-terminal derivatization of amino acids and peptides and detection by reverse phase HPLC.
  • UsesIn fluorescent labelling, column chromatography, HPLC.
  • Safety ProfilePoison by intravenous route, When heated to decomposition it emits very toxic fumes of Cland NOx
Dansyl chloride Preparation Products And Raw materials
Dansyl chloride(605-65-2)Related Product Information
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